hrp0092p3-139 | GH and IGFs | ESPE2019

Responses to Growth Hormone (GH) Therapy in Children with Short Stature with Normal GH Secretion and Slow Growth Velocity

Elawwa Ahmed , Soliman Ashraf

Background: Variability still exist about the growth response to growth hormone (GH) therapy in children with idiopathic short stature We describe the growth response to GH therapy ( 0.05 mg/kg/day) for > 2 years in 20 prepubertal children with idiopathic short stature (ISS) who had slow growth velocity ( < -1 SD), normal GH response to provocation and who were significantly shorter than their mid-parents height SDS MPHtSDS (-1 difference).<p class...

hrp0092p3-74 | Diabetes and Insulin | ESPE2019

Does Metformin Therapy Prolong the Honeymoon Period in Obese Adolescent with Hybrid Diabetes?

Hamed Noor , Elawwa Ahmed , Soliman Ashraf

Introduction: Hybrid diabetes is a challenging form od diabetes that need to be more studied. We describe a case of hybrid diabetes with a prolonged honeymoon due to the use of metformin.Case: Our patient is a 10 year old female patient who was diagnosed as type 2 DM on September 2017 at the age of 8 years. She was obese with BMI = 29.8 Kg/ m^2 with marked acanthosis nigricans. She had a patch of vitiligo on the face...

hrp0094p2-328 | Growth and syndromes (to include Turner syndrome) | ESPE2021

Excessive body hair, short stature and advanced bone age in a girl: Hypertrichosis versus adrenarche?

Soliman Ashraf , Elawwa Ahmed , Alaaraj Nada ,

A 6-year-old girl presented with hypertrichosis all over the body. She was born at term with a birth weight of 2 kg. She had a paralytic squint with excess body hair since birth. She had delayed developmental milestones. She had HTSDS = -1.3, BMI SDS = 0.66. Her Mid-parental HtSDS = 0. She had no other signs of puberty. (breast Tanner 1). Investigations revealed DHEAS = 3.3 Umol/L, Estradiol = 43 pmol/l, FSH = 1.5 IU/L. LH = 0.5 IU/L, Testo: 0.63 nmol/l, IGF1 = 200 ug/l, FT4 =...

hrp0094p2-335 | Multisystem endocrine disorders | ESPE2021

Obesity, vaginal bleeding and ovarian mass in a 5-year-old female girl with autoimmune hypothyroidism

Elsayed Shaymaa , Soliman Ashraf , Elawwa Ahmed ,

Case presentation: We report a five -year-old girl who presented for evaluation of obesity, abdominal distension, vaginal bleeding for two days, and abdominal distention. There was no history of local trauma or vaginal discharge associated with the vaginal bleeding and no suspicion of abuse. There was no purpura or bleeding from other sites. Her HtSDS = -1.3 SD and BMI SDS = + 1.5 SD. A large abdominal mass was palpable. There was no hepatomegaly, splenomegaly or lymphadenopat...

hrp0092p3-138 | GH and IGFs | ESPE2019

Factors Affecting Growth Response to Growth Hormone (GH) Therapy in Children with Short Stature and Normal GH and IGF-I Secretion and no Bone Age Delay

Elawwa Ahmed , Soliman Ashraf , Elalaily Rania

Background: There are inconsistencies in the results reported in a small number of previous studies into growth hormone (GH) treatment of short children with idiopathic short stature (ISS.Patients and Methods: Our study included 20 prepubertal (Tanner 1) or peri-pubertal (Tanner 2) children with short stature (HtSDS < -2) and/or HtSDS > 1SD below their mid parental height SD (MPHtSDS), slow Growth velocity( <...

hrp0086p2-p324 | Diabetes P2 | ESPE2016

Glargine versus Detemir Insulin During the Honeymoon Phase in a Child with Type1 Diabetes Mellitus

Alyafie Fawzia , Soliman Ashraf , Elawwa Ahmed

Background: The honeymoon period of type 1 diabetes mellitus (DM1) is characterized by reduced insulin requirements to <0.5 Units/kg per day while maintaining good glycaemic control.Case study: Seven years old boy who was diagnosed with type 1 diabetes mellitus presented with history of polyuria, polydipsia and weight loss for 3 weeks duration. His random Blood glucose=408 mg/dl with initial HBA1C 12.7%. Family history was unremarkable for diabetes ...

hrp0092p2-43 | Bone, Growth Plate and Mineral Metabolism | ESPE2019

A Rare Form of Vitamin D Receptors Dysfunction (vitamin D-dependent Rickets Type II) with Alopecia. A Case Report

Ahmed Shayma , Soliman Ashraf , Elawwa Ahmed , Hamed Noor , Alaaraj Nada

Introduction: VDDR II is an autosomal recessive disorder caused by a defect in the vitamin D receptor gene located on chromosome 12q12–q14. Thus far, 13 mutations have been identified. It is characterized by hypocalcemia, secondary hyperparathyroidism, and early onset severe rickets. Here we report a case of a severe form of rickets associated with alopecia.The Case: This 23-month-old boy was born at term to consang...

hrp0094p2-395 | Sex differentiation, gonads and gynaecology or sex endocrinology | ESPE2021

Cognitive function and linear growth in Prednisone-treated children with salt-wasting congenital adrenal hyperplasia

Elsayed Shaymaa , Soliman Ashraf , Omar Tarek , Ibrahim Sandra , Elawwa Ahmed ,

Introduction: Congenital adrenal hyperplasia (CAH) is a disorder with a wide spectrum of severity. Impaired cognition has been reported in patients with CAH, although the findings have been conflicting. It has been hypothesized that the major causes of the deficits are prenatal hormonal imbalances and/or excessive glucocorticoid treatment.Objective: The objective of this study was to investigate cognitive function in chi...

hrp0094p2-104 | Diabetes and insulin | ESPE2021

The clinical characteristics of hybrid diabetes (HD) in children and their response to treatment.

Hamed Noor , Soliman Ashraf , Alaaraj Nada , Elawwa Ahmed ,

Introduction: The term hybrid diabetes (HD) describes a form of diabetes in which hyperglycemia occurs in obese children in the presence of positive autoimmunity against the beta cells. Few data are available about the clinical presentation and the course of disease in children with this form of diabetes.Aim: We describe the clinical characteristics and response to treatment in 7 children with hybrid diabetes.<p clas...

hrp0094p2-290 | Growth and syndromes (to include Turner syndrome) | ESPE2021

Linear growth response to growth hormone therapy in underweight versus normal-weight children with idiopathic short stature (ISS)

Elawwa Ahmed , Soliman Ashraf , ElSiddig Sohair , Farag Marwa ,

Introduction: Growth hormone (GH) increases lean body mass and reduces fat mass. However, the long-term changes in weight status during growth hormone treatment, according to age and weight status at the onset of treatment, have not previously been reported in large data sets.Aim: To identify the growth response to GH therapy in underweight versus normal weight short children.Patients and Methods: ...