hrp0092p2-111 | Fat, Metabolism and Obesity | ESPE2019

Osteoprotegerin and Metabolic Status in Children with Obesity

Mikhno Hanna , Solntsava Anzhalika , Dashkevich Helena

Objective: determination of changes in metabolic status and osteoprotegerin concentrations in obese children.Methods: We examined 120 children in the University Hospital (Minsk) from 2017 to 2019 yrs. Their anthropometric parameters (height, weight, body mass index (BMI)) were determined. Blood levels of osteoprotegerin (OPG), insulin were determined. In the biochemical blood test, the parameters of uric acid, insulin we...

hrp0089p3-p137 | Fat, Metabolism and Obesity P3 | ESPE2018

The Level of the Vitamin D and Metabolic Status in Children with Obesity

Mikhno Hanna , Solntsava Anzhalika , Dashkevich Helena

Objective: Determination of changes in metabolic status and vitamin D concentrations in obese children.Methods: We examined 212 children in the University Hospital (Minsk) from 2016 to 2018 years. Their anthropometric parameters (height, weight, body mass index (BMI)) were determined. Blood levels of vitamin D, insulin, uric acid were determined. All children were divided into 2 groups: group 1 children with morbid obesity – 140 patients (90 boys(B)...

hrp0092p3-7 | Adrenals and HPA Axis | ESPE2019

Rare Case of Cortisol Producing Tumour in 14 Years Old Girl

Gärskog Helena , Mattsson Mattias , Lundberg Elena

Background: Adrenocortical Carcinoma (ACC) represents 0.16% of all pediatric neoplasm in children, 0-14.9 years, diagnosed between 1984-2010 according to Swedish Childhood Cancer Registry. ACC is most frequent in girls below 4 years of age.Case: A physically active 14 years old girl was referred due to growth velocity 0 cm over the last year. Her history revealed substantial weight gain (photos), pubertal arrest prem...

hrp0089p2-p001 | Adrenals and HPA Axis P2 | ESPE2018

Contribution of Direct Measurements of Steroids by Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) in Non-classical Adrenal Hyperplasia (NCCAH)

Agnani Helena , Houang Muriel , Egether Thibaut , Netchine Irene , Lamaziere Antonin

Background: To diagnose non classical congenital adrenal hyperplasia (NCCAH) and adrenal insufficiency (AI), current guidelines recommend ACTH test. Cutoffs for 17 hydroxyprogesterone (17OHP) and cortisol are derived from immunoassays values. Thanks to a recently developed and validated mass spectrometry approach (LC-MS/MS) we routinely quantify simultaneously 16 circulating steroids and we are able to speculate on new cut off values and uses.<p class="abs...

hrp0089p3-p046 | Bone, Growth Plate &amp; Mineral Metabolism P3 | ESPE2018

The Level of the Vitamin D and Bone Mineral Density in Children with Obesity

Mikhno Hanna , Solntsava Anzhalika , Vasilieva Natalia , Dashkevich Helena

Objective: To evaluate bone mineral density (BMD) and its relationship with vitamin D in children with obesity.Methods: We examined 110 children in the University Hospital (Minsk) from 2015 to 2018 yrs. Their anthropometric parameters (height, weight, body mass index (BMI)) were determined. Body composition with evaluating of mineral component were made by dual energy X-ray absorptiometry with the calculation of feet, hands, spine, ribs, hips BMD (g/cm<s...

hrp0089p1-p266 | Thyroid P1 | ESPE2018

Childhood Thyroid Autoimmunity and Relation to Islet Autoantibodies in Children at Risk for Type 1 Diabetes

Jonsdottir Berglind , Larsson Christer , Jonsson Ida , Lundgren Markus , Larsson Helena

Background: The aim was to determine prevalence and age at seroconversion of thyroid autoimmunity and relation to islet autoantibodies, gender and HLA-DQ genotypes in children followed from birth because of increased genetic risk for type 1 diabetes.Methods: In 1874 10-year-old children followed in the Diabetes Prediction in Skåne (DiPiS) study, blood samples were analysed for autoantibodies against thyroid peroxidase (TPOAb), thyroglobulin (TGAb), ...

hrp0086p1-p451 | Fat Metabolism and Obesity P1 | ESPE2016

The Frequencies of 5-HTTLPR Locus in Promotor Part of Serotonine Transporter Gene (SLC6A4) Polymorphism in Children with Different Forms of Obesity

Zagrebaeva Olga , Solntsava Anzhalika , Aksyonova Elena , Seyitnazarova Ayjan , Dashkevich Helena

Background: Serotonine transporter gene (SLC6A4) polymorphism is one of genetic aspects of appetite and mood disorders.Objective and hypotheses: To determine the frequencies of 5-HTTLPR locus in promotor part of serotonine transporter gene (SLC6A4) polymorphism in children with different forms of obesity.Method: We examined 191 pubertal obese children. Patients were divided: Group 1 (simple obesity) 143 children, 14.3±1.8 year...

hrp0086p1-p467 | Fat Metabolism and Obesity P1 | ESPE2016

The Peculiarities of Neurotransmitters Levels in Children with Obesity and Different Genotypes of COMT Gene

Zagrebaeva Olga , Solntsava Anzhalika , Aksyonova Elena , Seyitnazarova Ayjan , Dashkevich Helena

Background: Polymorphic genes Val158Met gene catechol-O-metiltrasferaz (COMT) are used to be responsible for less neurotransmitters utilization.Objective and hypotheses: To determine the peculiarities of neurotransmitters levels in children with obesity and different genotypes of COMT gene.Method: We examined 191 pubertal obese children. Patients were divided: Group1 (simple obesity) 143 children, 14.3±1.8 years, 30.6±2.8...

hrp0084p3-735 | Diabetes | ESPE2015

Cardiovascular Risk Factors in Children and Adolescents with Type 1 diabetes

Ferreira Carla , Ferreira Helena , Correia Filipa , Meireles Carla

Background: Diabetics have an increased risk of cardiovascular disease. In young adults with type 1 diabetes mellitus (T1DM), cardiovascular events are more often the cause of premature death than nephropathy. In pediatric T1DM population, 35% have 2 or more cardiovascular risk factors (cvRF).Objective and hypotheses: This study aimed to determine the prevalence of traditional cvRF in children and adolescents with T1DM, and their association with the deg...

hrp0084p3-767 | Diabetes | ESPE2015

Type 1 Diabetes in Pediatric Patients: Demographic and Clinical Characterisation

Ferreira Helena , Ferreira Carla , Correia Filipa , Meireles Carla

Background: Type 1 diabetes is one of the most common chronic disease in pediatric age. The incidence is increasing worldwide, with significant variations between countries. In Portugal, the prevalence in pediatric age is about 0.16%.Objective and hypotheses: This study aims to characterize a pediatric population with type 1 diabetes and to identify factors influencing the metabolic control.Method: Retrospective analysis of childre...