hrp0082p2-d1-415 | Growth Hormone | ESPE2014

IGF1 is Associated with a More Favourable Pattern of Body Composition in Obese Children

Inzaghi Elena , Pampanini Valentina , Alessio Paola , Fiori Rossana , Ferroli Barbara Baldini , Cianfarani Stefano

Background: Recent studies have suggested a role of IGF1 as a candidate prognostic marker for cardiometabolic complications of obesity.Objective: To investigate the relationship between IGF1 serum levels and both biochemical and metabolic parameters as well as body composition in a cohort of obese children.Methods: obese subjects (130F/157M), aged 11.2±2.7 years, were studied. Anthropometry, biochemical and metabolic parameter...

hrp0086p1-p926 | Thyroid P1 | ESPE2016

Minimally Invasive Video-Assisted Thyroid Surgery in Children: A Single Center Ten-Years Experience

Ferro Giusy , Martini Ludovica , Ferroli Barbara Baldini , Benevento Danila , Ubertini Graziamaria , Cappa Marco , Lombardi Celestino Pio , Grossi Armando

Background: Improved tools for diagnosis, a higher malignancy risk in thyroid nodules and the referral to surgery in Grave’s disease when medication fails, have lead to increased thyroidectomies in children.Objective and hypotheses: The aim of our study was to evaluate thyroid surgery outcomes and the presence of transient or permanent complications, in a cohort of children who underwent surgery, with the same surgical team, in the last 10 years.</p...

hrp0084p3-1033 | Growth | ESPE2015

Birth Length and Metabolic Syndrome in Obese Children

Inzaghi Elena , Ferroli Barbara Baldini , Fintini Danilo , Grossi Armando , Fiori Rossana , Spadoni Gianluigi , Scire Giuseppe , Cianfarani Stefano

Background: Low birth weight is associated with cardiometabolic risk in adulthood. To date, there is no evidence of a relationship between birth length and metabolic risk.Objective and hypotheses: To evaluate the relationship between birth size and risk of metabolic syndrome (MetS) in obese children.Method: 41 obese children were studied (23 females/18 males, 13.2±1.26 years). All patients underwent anthropometric, biochemical...

hrp0089p1-p264 | Thyroid P1 | ESPE2018

Thyroid Nodules in a Childhood Cancers Survivors Population: A Monocentric Experience

Peschiaroli Emanuela , Ubertini Graziamaria , Grossi Armando , Ferro Giusy , Martini Ludovica , Paone Laura , De Pasquale Maria Debora , Ferroli Barbara Baldini , Cappa Marco

Thyroid nodules are rare in pediatric age with an incidence of 1.8–3%. However, the risk of thyroid cancer is much higher in the pediatric population compared with adults. Among the pediatric cancer survivors there is an increased risk of developing a secondary malignancy and the thyroid cancers account for about 10% of these secondary tumors. From 2004 to 2017, we have recruited 43 patients (22 females; 21 males) with thyroid nodules among a population who had presented ...

hrp0092p1-300 | Adrenals and HPA Axis (2) | ESPE2019

Growth Trajectory and Final Height in Children with Non Classical Congenital Adrenal Hyperplasia

Wasniewska Malgorzata , Morabito Letteria Anna , Baronio Federico , Einaudi Silvia , Salerno Maria Carolina , Bizzarri Carla , Russo Gianni , Chiarito Mariangela , Grandone Anna , Guazzarotti Laura , Spinuzza Antonietta , Di Carlo Silvia , Ortolano Rita , Balsamo Antonio , Abrigo Enrica , Ferroli Barbara Baldini , Alibrandi Angela , Capalbo Donatella , Faienza Maria Felicia

Background: Subjects with non classical congenital adrenal hyperplasia (NCCAH) often present an increased growth velocity secondary to elevation of adrenal androgens that promote early bone maturation and compromise final height (FH). The aim of the study was to analyze prognostic factors affecting growth trajectory and FH in children with NCCAH.Design: retrospective, multicentric studyStud...

hrp0086p2-p513 | Fat Metabolism and Obesity P2 | ESPE2016

Low Birth Weight is not Associated with Increased Risk of Metabolic Syndrome in Obese Children and Adolescents

Inzaghi Elena , Fintini Danilo , Baldini Ferroli Barbara , Grossi Armando , Pedicelli Stefania , Bizzarri Carla , Fiori Rossana , Spadoni Gianluigi , Scire Giuseppe , Cappa Marco , Cianfarani Stefano

Background: Children born small for gestational age (SGA) are at risk for metabolic syndrome (MetS) as adults and show a higher prevalence of MetS components.Objective and hypotheses: To define the association between low birth weight and the presence of MetS in a cohort of obese Italian children and adolescents.Method: The presence of MetS was studied in a cohort of obese (BMI >90th centile) children and adolescents consisting...

hrp0086pl1 | Environmental chemicals, brain development and human intelligence | ESPE2016

Environmental Chemicals, Thyroid Hormone and Human Intelligence

Demeneix Barbara

Thyroid hormone is the only hormone for which all babies are screened at birth. This is because it has been known for decades that the consequences of thyroid hormone insufficiency during postnatal development, cretinism, are severe and irreversible. However, the last 15 years have witnessed major, and unexpected, insights how thyroid hormone acts during prenatal brain development across vertebrates. For instance, even mild maternal hypothyroidism or hyperthyroidism during ear...

hrp0094wg4.1 | ESPE Working Group on Disorders of Sex Development (DSD) Symposium | ESPE2021

New insights into sex differentiation and their relevance to disorders of sex development

Nicol Barbara ,

Embryos initially form undifferentiated gonads, reproductive tracts and external genitalia that will progressively acquire female or male characteristics. This fate decision is initiated in the undifferentiated gonads and depends on sex chromosomes and fine-tuned expression of complex networks of molecular pathways. Defects at different levels of this cascade of events can trigger a large spectrum of Disorders of sex development (DSDs), defined as “congenital conditions w...

hrp0082p1-d3-19 | Adrenals &amp; HP Axis (1) | ESPE2014

Development of Scotland Wide Process for Management of Acute Adrenal Insufficiency

Wardhaugh Barbara S , Reid Jacquie

Background: The Scottish Paediatric Endocrine Managed Clinical Network is committed to providing equity of care across Scotland. A key role identified by the nurses group is developing information leaflets supporting patient care. It was recognized that there was no local unified approach to the management of adrenal insufficiency, especially in the home, community and acute setting. Of particular concern was the lack of a pathway of care from home to hospital and involvement ...

hrp0089p3-p222 | Growth &amp; Syndromes P3 | ESPE2018

Development of an Online Learn-pro Module to Support Health Care Professionals Knowledge about Growth and Puberty

Wardhaugh Barbara , Shaikh Mohamad Guftat , Schulga John

Background: The Scottish Paediatric Endocrine Managed Clinical Network is committed to providing equity of care and education across Scotland. A key role is the education of health care professionals and how this is delivered. An extensive survey using a Learning Needs Analysis Tool was completed to ascertain learning needs and their delivery across Scotland. This highlighted the desire to have online learning available to health professionals.Objective:...