ESPE Abstracts

Relationship between polycystic ovary syndrome (PCOS) and thyroid autoimmunity has been recently suggested by several authors. Autoimmune thyroiditis (AIT) is the most prevalent autoimmune disease and link between AIT and PCOS has been reported in adult women. There is a hypothesis that functional autoantibodies could contribute to the development of PCOS. The aim of the study was to evaluate the prevalence of thyroid autoimmunity in adolescent girls with PCOS. Forty five adol...

Background: Turner syndrome (TS) predisposes to obesity and related metabolic disorders and presents a high risk of congenital heart defects. Growth hormone (GH) treatment used in TS girls also affects the parameters of carbohydrate-lipid metabolism. Thus, the search for new markers that could be early predictors of metabolic disorders seems to be justified.Objective and Method: The assessment and comparison of MMP-1, MMP-2, MMP-9 (matri...

Context: Turner syndrome (TS) predisposes to obesity and related disorders being a part of the metabolic syndrome. As TS population is at a higher risk of cardiovascular diseases research for laboratory markers of metabolic complications is ongoing. Based on our previous observation special significance is attributed to MMPs (matrix metalloproteinases), their inhibitors TIMPs and neurotrophic factors, such as BDNF (Brain-Derived Neurotrophic Factor) and GDNF (...

Background: The estimated estradiol (E2) dose required for pubertal induction in hypogonadal girls is about 1/10 of the adult dose. Previous studies have shown that it is possible to provide an individualized and physiological dose for pubertal induction by cutting the patch into smaller pieces. However, the manufacturers do not guarantee stability or utility of cut E2 patches, primarily designed for postmenopausal women, and have no interest in that eval...

Background: Both, obesity and hyperandrogenism are the conditions that can influence many different health domains, also may affect the mental and social wellbeing components of subject’s life.Study objective: To evaluate whether body weight status and clinical hyperandrogenism may influence social competencies and psychological gender features in adolescent girls.Design & participants: In 104 adolescent girls clinical eva...

Background: Analysis of steroids by gas chromatography-mass spectrometry (GC-MS) defines a subject’s steroidal fingerprint. Here, we compare the steroidal fingerprints of obese children with or without liver disease to identify the ‘steroid metabolomic signature’ of childhood non-alcoholic fatty liver disease.Methods: Urinary samples of 85 children (43 girls) age 8.5–18.0 with obesity (BMI >97%) were quantified for 31 steroid meta...

Background: The mechanisms underlying dyslipidaemia in the context of polycystic ovary syndrome may include not only metabolic aberrations but also hormonal factors, in particular hyperandrogenaemia.Objective and hypotheses: The aim of the study was to establish whether dyslipidaemia and metabolic control disturbances are related to hyperandrogenaemia in adolescent girls with type 1 diabetes mellitus (T1DM).Method: We studied 54 gi...

Context: Analysis of steroids by gas chromatography – mass spectrometry (GC-MS) defines a subject’s ‘steroidal fingerprint’. Here, we clustered steroidal fingerprints to classify childhood obesity by ’steroid metabolomic signatures’.Methods: Urinary samples of 87 children (44 F) age 8.5–18.0 with obesity (BMI >97%) underwent solid phase extraction, enzymatic hydrolysis and derivatization. 31 steroids metabolites wer...

Background: It remains unclear whether cardiometabolic and vascular risks in Turner syndrome (TS) are the consequence of unidentified intrinsic factors or, conversely, the result of modifiable risk factors, such as overweight. New markers that could explain the pathogenesis of metabolic complications are under investigation.Objective: The comparison of the selected biochemical cardiometabolic risk markers between TS patients and healthy controls.<p c...

Background: Risk of developing germ cell tumors (GCTs) in disorders of sex development (DSD) patients with karyotypes contain Y-chromosome or it’s material (Y) increase with age. The appropriate timing for prophylactic gonadectomy in these patients is still controversial.Aim: To analyze the gonadal tumor incidence and histological assessment of gonads in DSD (Y) patients who were treated in a single institution between 1997 and 03/2018.<p class=...