hrp0092p3-247 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology | ESPE2019

Turner's Syndrome Mosaicism 45X/47XXX with Iron Deficiency Anemia due to Menometrorrhagia

Chul Shin Woo , Jeong Hwal Rim , Kwon Eun Byul

Turner syndrome(TS) is a chromosomal disorder which occurs in 1/2500 - 1/3000 among female live births, characterized by short stature, pubertal failure and cardiac defects. Mosaicism of 45X/47XXX is extremely rare and accounts for 1.7% of the TS cases. TS with 45X/47XXX is more likely to have spontaneous puberty. The case we present herein is a 13-years old girl who was admitted to Chuncheon sacred heart hospital due to severe anemia. She was diagnosed with Turner syndrom...

hrp0089p2-p328 | Pituitary, Neuroendocrinology and Puberty P2 | ESPE2018

AMH and Inhibin B Level in Girls with Central Precocious Puberty

Jeong Hwal Rim , Hwang Il Tae , Yi Kyung Hee

Background/aim: Anti – Müllerian hormone (AMH) and Inhibin B (INHB) are considered as possible biomarker of central precocious puberty(CPP). This study investigated serum AMH and INHB level in central precocious puberty andanalyzed clinical factors associated with these two hormone levels.Methods: In total, 48 girls with CPP and 35 age – matched prepubertal girls were enrolled in the study. The subjects were divided into two groups as CPP ...

hrp0089p1-p103 | Fat, Metabolism and Obesity P1 | ESPE2018

Associations of Non-High-Density Lipoprotein Cholesterol with Metabolic Syndrome and Its Components in Korean Children and Adolescents: the Korea National Health and Nutrition Examination Surveys 2008–2014

Shim Young Suk , Jeong Hwal Rim , Yang Seung , Kim Eun Young , Hwang Il Tae

Background: In this study, we aimed to investigate the relationship between single-gender Korean references for non-high-density-lipoprotein cholesterol (non-HDL-C) and metabolic syndrome (MetS) in childhood.Methods: A total of 5,742 Korean children aged 10–18 years who participated in a national survey were included. The subjects were classified into three groups based on single-gender non-HDL-C levels as follows: <120 mg/dl (desirable), &#8805...

hrp0082p3-d1-881 | Perinatal and Neonatal Endocrinology | ESPE2014

A Case of Hyperinsulinism/Hyperammonemia Syndrome

Shim Young Suk , Jeong Hwal Rim , Lee Hae Sang , Lim Jung Sub , Hwang Jin Soon

Background: Hyperinsulinism/hyperammonemia (HI/HA) syndrome is a form of congenital hyperinsulinism (CHI) caused by a mutation in the GLUD1 gene. It is characterized by hyperinsulinemic hypoglycemia accompanying hyperammonemia.Objective and hypotheses: We report HI/HA syndrome with a 4-month-old male who hypoglycemic seizure.Method: A 4-month-old male infant presented with seizure caused by fasting-induced hypoglycemia. At the time...

hrp0082p3-d3-947 | Puberty and Neuroendocrinology (1) | ESPE2014

The Etiology of Central Precocious Puberty and Effect of GnRH Agonist for 2 years in Korean Boys

Shim Young Suk , Jeong Hwal Rim , Lee Hae Sang , Lim Jung Sub , Hwang Jin Soon

Background: GnRH agonist (GnRHa) are able to modify natural course of Central Precocious Puberty (CPP) in girls.Objective and hypotheses: We evaluated the etiology and the effect of GnRHa in Korean CPP boys.Method: Total 29 boys diagnosed for CPP from 2007 to 2012 were included in Ajou University Medical Center. Sellar MRI was performed in 26 of 29 patients (89.7%). CPP was diagnosed on the basis of i) onset evidence of testicular ...

hrp0089p1-p207 | Pituitary, Neuroendocrinology and Puberty P1 | ESPE2018

Urinary Gonadotropins as a Useful Non-invasive Marker of Central Precocious Puberty

Hwang Il Tae , Jeong Hwal Rim , Yang Seung , Shim Young Suk

Aims: The current study aimed that first morning voided (FMV) urinary gonadotropin measurements could be used as a noninvasive alternative to the gonadotropin-releasing hormone (GnRH) test in the assessment of the hypothalamic-pituitary-gonadal function in children.Methods: In a multi-center study, we compared FMV urinary gonadotropin concentrations with GnRH-stimulated serum gonadotropin levels in 140 girls aged 7–9 years who were evaluated for pub...

hrp0084p3-1145 | Puberty | ESPE2015

Changes in BMI During GNRH Agonist Treatment in Girls with Idiopathic Central Precocious Puberty and Early Puberty

Lee Hae Sang , Jeong Hwal Rim , Kim Eun Young , Hwang Jin Soon

Background: GNRH agonist (GnRHa) has been widely used for decades to treat in patients with central precocious puberty (CPP). There are severe studies concerning changes in body composition in CPP patients following GnRHa treatment, but the results are inconsistent.Objective and hypotheses: The aim of this study was to investigate the change of BMI in children treated with GnRHa for 2 years. Also, the present study was performed to assess whether BMI aff...

hrp0089p1-p243 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology P1 | ESPE2018

Circulating Makorin Ring Finger Protein 3 Levels Predict Central Precocious Puberty in Girls

Jeong Hwal Rim , Lee Hye Jin , Shim Yeong Suk , Kang Min Jae , Yang Seung , Hwang Il Tae

Background/aim: Puberty is a mysterious process about which much is as yet unknown. MKRN3 is involved in regulating the initiation of puberty by inhibiting gonadotropin releasing hormone (GnRH) secretion. This study evaluated the serum level of MKRN3 and investigated its diagnostic usefulness in girls with central precocious puberty (CPP). Changes in the MKRN3 concentration during GnRH agonist (GnRHa) treatment were also analyzed.Methods: In total, 41 gi...

hrp0092p1-407 | Pituitary, Neuroendocrinology and Puberty (2) | ESPE2019

No Association Between Serum Level of NPTX 1 and MKRN3 in Central Precocious Puberty

Rim Jeong Hwal , Tae Hwang Il

Abstract: Background: Makorin ring finger protein 3 (MKRN3) is most common genetic cause of central precocious puberty (CPP) and associated with the initiation of puberty. Although its actual function is veiled. Recent study reported MKRN3 interacted with and suppressed neural pentraxin-1 precursor (NPTX1) activity via polyubiquitination during early puberty in mice.Objective: The aim of this study was t...

hrp0092lb-21 | Late Breaking Posters | ESPE2019

How Can the Occurrence of Delayed Elevation of Thyroid Stimulating Hormone in Preterm Infants Born Between 35 and 36 Weeks Gestation be Predicted?

Jung Heo You , Ah Lee Young , Jeong Lee Yun , Hee Lim Youn , Rim Chung Hye , Han Shin Seung , Ho Shin Choong , Won Yang Sei

Objective: We evaluated frequency and risk factors of delayed TSH elevation (dTSH) and investigated follow-up outcomes in the dTSH group with venous TSH (v-TSH) levels of 6–20 mU/L according to whether late preterm infants born at gestational age (GA) 35–36 weeks had risk factors.Methods: The medical records of 810 neonates (414 boys) born at Seoul National University Hospital who had a normal neonatal screenin...