hrp0094p2-491 | Thyroid | ESPE2021

Pediatric Graves’ disease in southern Tunisia

Kmiha Sana , Zghal Mohammed Ali , Chabchoub Imen , Ameur Salma Ben , Aloulou Hajer , Kammoun Thouraya

Background: Hyperthyroidism is uncommon in children. Graves’ disease is the most common cause in pediatric population. The diagnosis is based on the presence of anti-TSH receptor antibodies. Pediatric Graves’ disease has some peculiarities mainly in term of treatment and evolution, since its prognostic is different than adults.Aim: The aim of this study is to describe the epidemiological, clinical and biological features of pediatric Graves...

hrp0094p2-159 | Diabetes and insulin | ESPE2021

Glucose 6 phosphate dehydrogenase deficiency diagnosed with hemolytic anemia triggered by diabetes mellitus type 1

Orman Burce , Cetinkaya Semra , Oner Nergis , Akcaboy Meltem , Fettah Ali , Guleray Lafcı Naz , Erdeve Senay Savas ,

Background: Glucose 6 phosphate dehydrogenase (G6PD) is expressed in all tissues and is necessary for the oxidant stress capacity of cells. G6PD deficiency is the most common enzymopathy in humans; it is among the important causes of hemolytic anemia. It has been reported that severe hemolytic anemia due to G6PD deficiency may develop in newly diagnosed diabetes, especially during the correction of hyperglycemia. To date, 9 cases have been described in the lit...

hrp0094p2-164 | Diabetes and insulin | ESPE2021

The Impact of COVID 19 Pandemic on Type 1 Diabetes Mellitus: An experience of a Tertiary Care Hospital in a resource limited country

Ayub Aqeela , Ijaz Sadaf , Qudrat Syeda Mamoona , Rani Tanzeela , Raziq Abdur , Ali Muhammad , Butt Taeed Ahmed ,

Background and Objectives: Managing type 1 diabetes (TIDM) in covid pandemic is a real challenge in resource limited countries like Pakistan. This study was aimed to determine the effects of covid 19 in managing type 1 diabetes in resource limited countries.Methods: Cross-sectional observational study, included all type 1 diabetes patients who were already enrolled in endocrine and diabetes clinic and were on regular fol...

hrp0094p2-241 | Fetal, neonatal endocrinology and metabolism (to include hypoglycaemia) | ESPE2021

Incidence of early neonatal hypoglycemia and some related risk factors in Qatar. A cohort study over two years (2018 and 2019)

Soliman Ashraf , Ali Hamdy , Alaaraj Nada , Alyafei Fawzia , Hamed Noor , Ahmed Shaymaa ,

Objective: The objective of this study is to determine the incidence of early neonatal hypoglycemia and to confirm potential risk factors.Study design: The study was conducted at a tertiary Medical Center in Qatar. between January 2018 and December 2019. First blood glucose concentrations of all infants admitted to the nursery were measured using a "point of care" analyzer (Accu-Chek). We recorded risk factors for hypoglycemia su...

hrp0094p2-291 | Growth and syndromes (to include Turner syndrome) | ESPE2021

Linear Growth and Weight gain in Infants with Significant Neonatal Hypoglycemia during the first two years of age: Comparison of infants of Diabetic Mothers (IDM) versus infants of non-diabetic mothers (INDM) with transient hyperinsulinemia (non-ketotic hypoglycemia)

Soliman Ashraf , Alaaraj Nada , Itani Maya , Jour Celine , Alyafei Fawzia , Hamed Noor , Alneimy Fatma , Ali Hamdy ,

Objective: Infants born to mothers with glucose intolerance are at an increased risk of having growth abnormalities at birth and postnatally. This study evaluated the growth pattern of IDMs from birth to the age of 2 years.Research Design and Methods: Anthropometric measures (z scores) from birth, 2,4.6,12,18 and 2 years were measured in 60 IDM and 40 infants of non-diabetic mothers who presented with significant neonatal hypoglycemia (p...

hrp0094p2-385 | Pituitary, neuroendocrinology and puberty | ESPE2021

A Practical Method for the Evaluation of Childhood Hypophysitis: Pituitary Stalk/Basilary Artery Ratio

Torel Ergur Ayca , Şimşek Fatma , Arslan Kubra , Ali Yinanc Mehmet ,

Introduction: Childhood hypophysitis (CH) is an extremely rare entity that has difficulties in definition and displays a wide variety of symptomatology. The volume and shape of pituitary gland may increase in physiological periods such as puberty and pregnancy, it may also change in various neuroendocrine and psychiatric diseases. It is important to distinguish physiological changes observed in the pituitary, especially in puberty, from hypophysitis.F...

hrp0095p2-151 | GH and IGFs | ESPE2022

A novel mutation of LHX3 is associated with combined hypopituitarism and dysmorphic face

Noorian Shahab , Savad Shahram , Saffari Fatemeh , Nikkhah Saeed , Talea Ali , Soltani Hedieh

The pituitary gland is a pea-sized organ located at the base of the brain. It synthesizes, and secretes, many hormones that control growth and development, and the functioning of the other endocrine glands. Panhypopituitarism is a condition of inadequate or absent production of all these hormones. LHX3 (LIM Homeobox 3) is a Protein-Coding gene involved in pituitary development. Mutations in this gene may result in a deficiency of multiple pituitary hormones. Here, we present a...

hrp0095p2-166 | Growth and Syndromes | ESPE2022

Postnatal growth in Preterm infants as a function of their head size (head circumference Z score (HCZ) at birth: Comparison between those who were with a large head (HCZ <-2) to those with normal Head size for gestational age (HCZ > -2)

Alyafei Fawzia , Soliman Ashraf , AlYousef Doaa , Shaat Mona , Itani Maya , Hamed Noor , Ahmed Shayma , Ali Hamdy

Suboptimal head growth in utero and in early neonatal life may affect linear growth and weight gain during infancy. We studied linear growth and weight gain of 56 preterms (GA = 33.5 +/- 2.2 weeks) with birth weight >1.5 < 2.5 kg) for two years. They were classified at birth into two groups (group 1 with HCZ <-1) (relatively small head for GA) (35 +/- 2 weeks) and group 2 with HCZ > -1 (GA = 33 +/- 1.7 weeks)Results: Preterm ...

hrp0095p1-320 | Growth and Syndromes | ESPE2022

International vs Qatar national growth data for identifying small and large-for-gestational-age newborns: A population-based study in Qatar

Alyafei Fawzia , Soliman Ashraf , Alqubasi Mai , Ali Hamdy , Alturk Mohamed , Alaaraj Nada , Hamed Noor , Ahmed Shayma

Background: To update the ongoing debate about the use of universal strict vs (local) national intrauterine growth charts, we compared the prevalence of small and large-for-gestational-age (SGA/LGA) infants according to international charts and national growth data.Methods: We classified singleton births from 33 to 42 weeks of gestation in 2016 and 2019 from Qatar (n = 92431), SGA (birthweight <10th percentil...

hrp0095p1-331 | Growth and Syndromes | ESPE2022

Prevalence of Obesity from birth to 3 years of age in infants born large for date (LGA): Infants with weight for age (WAZ) catch down vs those without catch down during the first year of life

Fawzia Alyafei , Ashraf Soliman , Saleha Abbsi , Fatima Alkhori , Nada Alaaraj , Shayma Ahmed , Noor Hamed , Hamdy Ali

Introduction: Infants whose weight is > the 90th percentile for gestational age are classified as large for gestational age (LGA). Catch-up and catch-down growth can be defined as an increase or decrease in WAZ by > 0.67 SD respectively during the infantile period. It was suggested that in LGA rapid catch-up and/or no catch-down during infancy may be associated with the development of overweight (OW) and obesity (OB) during childhood.<p class="abstex...