hrp0082p2-d2-551 | Puberty and Neuroendocrinology (1) | ESPE2014

The Effect of Combined GH and GnRH Agonist Treatment for Near-Final Height Improvement in True Precocious Puberty and Early Puberty

Kim Se Young , Kim Eun Young , Yi Kyung Hee

Purpose: The goal of treatment for true precocious puberty (TPP) and early puberty with GnRH agonist (GnRHa) is to prevent loss of genetic potential of target height (TH). And to regress secondary sex characteristics appropriate for patient’s age. But some patient’s growth velocity (GV) after treatment would decline and suggest that final height (FH) was not improved. So, we investigated the effect of combined GH and GnRHa treatment for near-FH (NFH) improvement....

hrp0089p2-p402 | Thyroid P2 | ESPE2018

Association of Thyroid Stimulating Hormone and Free Thyroxine with Cardiometabolic Risk Factors in Euthyroid Korean children and Adolescents Aged 10–18 Years: The Korean National Health and Nutrition Examination Survey 2015

Lim Jung Sub , Shim Young Suk , Kim Eun Young

Objective: The present study aimed to evaluate the association of free thyroxine (FT4) and TSH with insulin resistance indices in euthyroid Korean children and adolescents using nationally representative data.Methods: A total of 259 children and adolescents were included in data from The Korean National Health and Nutrition Examination Survey 2015.Results: TSH levels were significantly positively associated with HOMA-IR (β...

hrp0084p2-531 | Puberty | ESPE2015

Regional Brain Volume and Luteinising Hormone in Girls with Idiopathic Central Precocious Puberty

Kim Eun Young , Park Shin Eui , Kim Min Sun

Background: During puberty, gray matter (GM) volume decreases and white matter (WM) volume increases in brain. It has been suggested that pubertal hormones may induce some neuroanatomical changes during puberty. Central precocious puberty (CPP) is caused by premature activation of the hypothalamus-pituitary-gonadal axis in inappropriately early age. However, little is known about the differences of brain structure (especially brain volume) in idiopathic CPP. Also the relation ...

hrp0092p1-372 | Growth and Syndromes (to include Turner Syndrome) (2) | ESPE2019

A Considerable Role of NPR2 Mutation in Idiopathic Short Stature: Identification of Two Novel Mutations

Hwang Il Tae , Yi KyungHee , Kim Eun Young , Yang Seung

Introduction: C-type natriuretic peptide (CNP, NPPC gene) and its receptor, natriuretic peptide receptor B (NPR-B, NPR2 gene), is critical for endochondral ossification in growth plate. Biallelic NPR2 mutations are known as acromesomelic dysplasia, type Maroteaux which is characterized by severe short stature. A monoallelic NPR2 mutation has been suggested to mildly impair long bone growth.Obje...

hrp0092p2-241 | Pituitary, Neuroendocrinology and Puberty | ESPE2019

Effect of Gonadotropin-Releasing Hormone Agonist Treatment on Final Adult Height in Boys with Idiopathic Central Precocious Puberty

Kim Eun Young , Yi Kyung Hee , Lee Jae Hee

Purpose: Central precocious puberty (CPP) is less common in boys than girls; very little data is reported on long-term effects of gonadotropin-releasing hormone analog (GnRHa) treatment in boys with CPP. The aim of the study was to evaluate the impact of treatment with GnRHa on adult height (AH) and body mass index (BMI) in boys with idiopathic CPP.Subjects and Methods: In 18 boys with confirmed diagnosis of idiopathic C...

hrp0092p3-172 | Growth and Syndromes (to include Turner Syndrome) | ESPE2019

Pure Gonadal Dysgenesis with Partial Testicular Development Associated with Turner Syndrome with SRY

Hee Yi Kyung , Kim Eun Young , Han Heon Seok

Turner syndrome is the most common chromosomal disorder in girls. They present classically short stature and delayed puberty. Turner girls with 45,X karyotype show normal female external genitalia. But Turner patients containing 45,X/46,XY mosaicism, or Sex-determining Region Y(SRY) gene may have mixed gonadal dysgenesis with various external sexual differentiation or pure gonadal dysgenesis. Existence of Y chromosome particles in Turner syndrome implies that they have risk of...

hrp0089p3-p334 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology P3 | ESPE2018

Effect of Gonadotropin-Releasing Hormone Agonist Treatment in Boys with Central Precocious Puberty and Early Puberty

Kim Eun Young , Yi Kyung Hee , Lee Jae Hee

Purpose: Central precocious puberty (CPP) is less common in boys than girls; very little data is reported on effect of gonadotropin-releasing hormone analog (GnRHa) treatment in boys with CPP. The aim of the study was to evaluate growth changes in boys with CPP and early puberty (EP) treated with GnRHa therapy for 1 year.Subjects and Methods: In 60 (39 CPP and 21 EP) boys with confirmed diagnosis of CPP and EP, auxological (height, height standard deviat...

hrp0086p1-p723 | Pituitary and Neuroendocrinology P1 | ESPE2016

Effect of Dietary Control on Pubertal Onset and Immunoreactivity of Kisspeptin and Neurokinin B in Female Offspring Rats Fed High Fat Diet During Perinatal Period

Kim Eun Young , Jun Yonghyun , Yi Kyung Hee

Background: Nutrition is an important factor to regulate reproductive function. Some studies showed that high fat diet (HFD) may influence to puberty onset and irregular estrous cycles in the female rats. However, underlying regulation mechanism of nutrition on pubertal maturation and reproductive function is not well-known. Kisspeptin and neurokinin B (NKB) are an essential factor for regulation of pubertal development.Objective and hypotheses: In this ...

hrp0084p2-544 | Puberty | ESPE2015

Increasing BMI is Associated with Lower Luteinising Hormone Levels in Girls with Central Precocious Puberty at the Early Pubertal Stage

Lee Hae Sang , Kim Eun Young , Hwang Jin Soon

Background: Girls with precocious puberty have high LH levels and bone age was advanced over chronological age by 1 year. Obese children start puberty at an earlier age than non obese children. The mechanisms that cause obese children to grow faster starting from early childhood are not well defined.Objective and hypotheses: We analysed the effects of obesity on luteinising hormone (LH) secretion by using gonadotropin-releasing hormone (GnRH) tests in gi...

hrp0082p3-d3-949 | Puberty and Neuroendocrinology (1) | ESPE2014

The Perception of Body Image and Self-Esteem in Girls with Precocious Puberty, Being Treatment with GnRH Analogue

Kim Eun Young , Choi Min Sun , Kim Se Young , Hwang Il Tae

Background: Precocious puberty (PP) is associated with psychological and behavioral problems. However, little is known about body image and psychological features in girls with PP, being treatment with GnRH analogues.Objective and hypotheses: This study aimed to evaluate the perception of body image and self-esteem in girls with PP, were receiving GnRH analogue therapy.Method: From March to August 2013, 82 girls with PP with GnRH a...