hrp0095p1-499 | GH and IGFs | ESPE2022

Long-term safety and effectiveness of recombinant human growth Hormone inKorean pediatric patients with growth disorders: 9-year interim analysis fromLG Growth Study

Kim Yoo-Mi , Chung Sochung , Rhie Young-Jun , Hyun Kim Jae , Chae Hyun-Wook , Ho Choi Jin , Ah Lee Young , Sang Lee Hae , Tae Hwang Il

This study aimed to evaluate the long-term safety and effectiveness of recombinant human growth hormone (rhGH; Eutropin®, Eutropin®Pen, Eutropin®AQ, and Eutropin®Plus, LG Chem, Ltd.) treatment in Korean pediatric patients. This observational study has been conducted since 2011, and the data were collected up to August 2021 for interim analysis. The incidence rates of all adverse events (AEs) were assessed for safety a...

hrp0092fc8.6 | Pituitary, Neuroendocrinology and Puberty Session 1 | ESPE2019

Source and Changes in Serum Level of Kisspeptin in Female Rats at Different Developmental Stages

Kwon Ahreum , Kim Ho-seong , Suh Jungwhan , Choi Han-saem , Song Kyungchul , Suh Yongsuk

Introduction: The Kiss1/Kisspeptin/Kiss1r system is essential for puberty onset and reproductive system development, especially in the hypothalamus. Nevertheless, Kiss1 is expressed in other organs. Additionally, serum kisspeptin has been associated with puberty. However, studies on the developmental changes in serum kisspeptin levels and its main source are limited. Therefore, the aim of this study was to evaluate the developmental ...

hrp0092p1-62 | Fat, Metabolism and Obesity | ESPE2019

Short-term Treatment of Liraglutide in Patient with Prader-Willi Syndrome

Cheon Chong Kun , Yoon Ju Young , Choi Im Jeong , Kim Hyun-Ji

Background: Prader-Willi syndrome (PWS) is a genetic disorder associated with developmental delay, obesity, and obsessive behavior related to food consumption. Treatment options for weight control in those patients is limited and there are controversies for a surgical approach. Saxenda® (liraglutide) injection 3 mg is indicated as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adult patients with obes...

hrp0092p1-75 | GH and IGFs | ESPE2019

Impact of -202 IGFBP-3 Promoter Polymorphism on Growth Responses in Korean Children with Idiopathic Short Stature

Hwang II Tae , Yi Kyung Hee , Kim Eun Young , Yang Seung

Purpose: Our previous study showed no correlation between -202 A/C IGFBP-3 promoter polymorphism and Δheight SDS in children with growth hormone deficiency. We investigated the influences of the -202 IGFBP-3 polymorphism on 1-year follow-up outcomes of GH treatment in Korean children with ISS.Methods: Data was obtained from 81 children with idiopathic short stature (peak serum growth hormone (GH) ≥ 7.0 ng/mL b...

hrp0092p1-101 | Pituitary, Neuroendocrinology and Puberty | ESPE2019

Identification of Novel Mutations in FGFR1 and Functional Characteristics in Patients with Isolated Gonadotropin-Releasing Hormone Deficiency

Lee Yena , Huh Juyoung , Oh Arum , Kim Gu-Hwan , Yoo Han-Wook , Choi Jin-Ho

Background: Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is caused by a deficiency in GnRH production, secretion or action and a highly heterogeneous disorder with wide phenotypic spectrum including Kallmann syndrome (KS) with anosmia and normosmic idiopathic hypogonadotropic hypogonadism (nIHH). More than 30 different causative genes have been identified in several studies. FGFR1 mutations have been identified in about 3–10&#3...

hrp0092p1-174 | Bone, Growth Plate and Mineral Metabolism (1) | ESPE2019

The Optimal Dosage of Vitamin D Supplement for Vitamin D deficiency in Korean Children and Adolescents

Yang Seung , Hee Yi Kyung , Kim Eun Young , Hwang Il Tae

Purpose: Vitamin D deficiency (VDD) is very common nowadays in children as well as in adults, probably due to decreased exposure to sunlight. In Korea, the prevalence of VDD was 47% in teenage boys and 65% in teenage girls. However, the optimal dosage regimen for correcting deficiency is unknown. We investigate the change of serum 25(OH) vitamin D concentration according to the treatment dosage and duration in VDD.Methods...

hrp0092p1-385 | Growth and Syndromes (to include Turner Syndrome) (2) | ESPE2019

Saliva Might be a Good Alternative DNA Source for Whole Exome Sequencing to Identify Genetic Causes of Short Stature

Cheon Chong Kun , Yoon Ju Young , Choi Im Jeong , Kim Hyun-Ji

Background: Genetics plays a strong role in height. However, for most patients, no cause for the short stature can identified. Whole-exome sequencing (WES) is becoming an increasingly important tool for detecting novel genetic causes of short stature. Blood is the preferred DNA source for germline studies using WES. However, DNA from saliva is a more convenient and cost-effective alternative.Objectives: We aim to identif...

hrp0092p2-122 | Fat, Metabolism and Obesity | ESPE2019

Insulin-like Growth Factor-1 and Binding Protein-3 in Children with Metabolic Syndrome

Lee yoonji , Ahn Moonbae , Kim Seulki , Choi yujung , Cho Wonkyung , Jung Minho , Suh Byung-Kyu

Purpose: To examine the association of Insulin-like growth factor-1 (IGF-1) and binding protein-3 (IGFBP-3) with metabolic parameters of childhood obesity and assess its relationship with the presence of metabolic syndrome (MetS)Methods: A cross-sectional study of total 307 children and adolescents referred for growth assessment was performed. Subjects were divided into three groups based on body mass index (BMI) percent...

hrp0092p2-282 | Thyroid | ESPE2019

Treatment for Graves' Disease in Children and Adolescents: A Long-Term Retrospective Study at a Single Institution

Kim Min-Sun , Song Ari , Park Hyojung , Cho Sung Yoon , Jin Dong-Kyu

Background: Management options are limited for the treatment of Graves' disease (GD) in children and adolescents. Antithyroid drugs (ATDs) remain the first-line therapy in patients with GD, despite a high relapse rate. We investigated the clinical characteristics, treatment, the outcome, and predictors of a remission of children and adolescents with GD at a single center.Methods: We retrospectively reviewed the medic...

hrp0092p3-13 | Adrenals and HPA Axis | ESPE2019

Genotype and Phenotype, Growth Outcome in 33 Korean Patients with 21-Hydroxylase Deficiency

Yoon Ju Young , Choi Im Jeong , Kim Hyun-Ji , Cheon Chong Kun

Purpose: This study aimed to describe gene mutations and growth outcome in patients with 21-hydroxylase deficiencyMethods: Subjects were diagnosed as 21-hydroxylase deficiency by direct Sanger sequencing or multiple ligation-dependent probe amplification analysis and visited Pusan National University Children's Hospital from July 2008 to April 2019.We investigated the genotype, phenotype and growth profiles.<p cl...