hrp0089p3-p064 | Bone, Growth Plate & Mineral Metabolism P3 | ESPE2018

Hypercalcemia Associated with Increased Parathyroid Hormone-related Protein (PTHrP) in a Patient with Medulloblastoma Successfully Treated with Pamidronate

Kang Seok Jin , Kim Heung Sik

We report a patient with medulloblastoma showing severe hypercalcemia and a raised PTHrP serum level. He was a 19-year-old with a history of recurrent medulloblastoma. He developed constipation, lethargy and altered mentality for 3 weeks. There was no family history of hypercalcemia. Laboratory test revealed hypercalcemia of 18.2 mg/dL. PTHrP increased to 10.7 pmol/L (normal range: <1.1 pmol/L), whereas serum level of intact parathyroid hormone was suppressed to 5 pg/mL (n...

hrp0089p1-p178 | Growth &amp; Syndromes P1 | ESPE2018

Identification of Three Novel Mutations in 10 Pediatric Patients with Unexplained Syndromic Short Stature Identified by Targeted Exome Sequencing in Korea

Kun Cheon Chong , Kim Yoo-Mi

Objectives: Owing to the tremendous advances in next-generation sequencing technology, numerous monogenic causes of growth disorders have been identified. Identifying novel rare genetic causes of short stature (SS) is quite challenging. In 2017, we reported a mutation analysis of 15 patients with undiagnosed syndromic SS or overgrowth. In this study, 6 mutations in another 10 Korean patients with unexplained syndromic SS are reported. The aim of this study is ...

hrp0089p2-p365 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology P2 | ESPE2018

Prospective Investigation of the Influence of Triptorelin Treatment on Body Weight and Body Mass Index of Girls Who Were Diagnosed with Idiopathic Precocious Puberty or Early Puberty

Kang Seokjin , Shim Yejee , Sik Kim Heung

Background: Gonadotropin-releasing hormone agonists (GnRHa) have been widely used to treat patients with central precocious puberty (CPP). Several studies have investigated changes in body composition in patients with CPP following GnRHa treatment. But the results are inconsistent. This study aimed to investigate the influence of GnRHa treatment on the weight and body mass index (BMI) of girls who were diagnosed with idiopathic CPP or early puberty (EP)....

hrp0086p2-p415 | Gonads &amp; DSD P2 | ESPE2016

Reproductive Function of Central Precocious Puberty in Girls: A Systematic Review

Kim Ji Hyun , Lee Jong Bin

Background: GnRH analogues are the treatment of choice for central precocious puberty. It has been proven beneficial effects on final adult height, but the reproductive function has many debate especially about PCOS. The criteria used for the diagnosis of PCOS can be more difficult to judge because it is not uniform between the studies.Method: The Medline, Cochrane, EMBASE, Web of Science, SCOPUS data bases were searched for studies published up to Janua...

hrp0086p2-p495 | Fat Metabolism and Obesity P2 | ESPE2016

The Cutoff Values of Indirect Indices for Measuring Insulin Resistance in Korean Children and Adolescents

Kim Jun Woo , Han Heon-Seok

Background: With the use of insulin resistance (IR) as a cause of metabolic syndrome (MetS), it is possible to screen the risk group of childhood MetS. Indirect index of IR can be estimated thru homeostasis model assessment (HOMA) of IR. Another index of triglyceride and glucose (TyG) were evaluated and equally effective in some adult studies. However, we do not have consistent prevalence rate and percentile distribution of MOMA-IR and TyG index in children and adolescent popu...

hrp0082p1-d2-210 | Reproduction (1) | ESPE2014

Messenger Ribonucleic Acid Expression of Kiss-1 and Serum Level of Kisspeptin in Rat at Different Developmental Stages

Reum Kwon Ah , Hee Kim Duk , Min Ahn Jung , Song Kyungchul , Wook Chae Hyun , Kim Ho-Seong , Jin Kim Ye , Hyuk Kim Yong

Background: KiSS-1 and its product, kisspeptin is necessary for puberty onset and proper adult gonadal function due to its stimulatory effect on the secretion of gonadotropin-releasing hormone (GnRH). Although the pathophysiological importance of KiSS-1 and kisspeptin is well known, the developmental patterns of expression of KiSS-1 genes and serum level of kisspeptin have not been explored to date.Objective and hypotheses: We report herein the expressio...

hrp0082p2-d3-361 | Diabetes (2) | ESPE2014

Comparison of HbA1c and OGTT to Diagnose Diabetes in Korean Children

Kim Min Sun , Lee Dae-Yeol

Background: Recently, the American Diabetes Association introduced HbA1c test for diagnosing diabetes with a cut point of ≥6.5% in addition to criteria based on glucose levels.Objective and hypotheses: The aim of this study was to evaluate the correlation between plasma glucose (fasting plasma glucose (FPG) and 2-h plasma glucose after an OGTT (2-h OGTT)) and HbA1c for diagnosing diabetes in Korean children.Method: A total of...

hrp0082p3-d3-845 | Growth (2) | ESPE2014

Skeletal Maturity of Radius, Ulna, and Short Bones in TW3 Method for Children in Korea

Lee Jieun , Kim Jaesuk , Cho Jurae

Purpose: The Tanner-Whitehouse (TW) system is the method of choice for skeletal maturity assessment in both clinical practice and auxological research (Tanner et al. 1983), and it has been used to estimate skeletal maturity in groups of children from all over the world. This study aimed on analyzing the characteristic of the RUS maturity of Korea children by evaluating RUS maturity of Korea children using the TW3 method, compared with children in China and Japan<stron...

hrp0084p3-679 | Bone | ESPE2015

Carpal Spasm in Hypophosphataemic Patient

Lee Sanghyun , Sim Yeji , Kim Heungsik

Background: Phosphate is an essential ion and plays a vital role in many physiological processes. Carpopedal spasm is known as a symptom of hypocalcaemia, or rarely, hypomagnesemia. We present an unusual case of carpal spasm seen in hypophosphataemia.Case presentation: 14 year old boy was admitted with acute onset of both carpal spasm. He had shrimp salad made 2 days ago, and two times of vomiting and large amount of diarrhea was developed before carpope...

hrp0084p3-920 | GH &amp; IGF | ESPE2015

Is the Insulin Secretion in Pancreatic Beta Cells Related with IGF-1/IGFBP-1 Axis in Korean Children?

Kim Min Sun , Lee Dae-Yeol

Background: The IGF system is involved in the development of metabolic and cardiovascular disease. This study aimed to investigate the association of insulin-like growth factor-1 (IGF1), IGF-binding protein-1 (IGFBP1) and IGFBP3 with insulin resistance and type 2 diabetes in children.Methods: We included 36 children aged 10 to 16 years without known diabetes, medication, chronic disease. They were classified into three groups according to the results of ...