hrp0082p1-d1-105 | Fat Metabolism & Obesity | ESPE2014

Being Overweight During the Peripubertal Period Modifies the Leptin Induced Changes in Hypothalamic Neuropeptides Involved in Metabolism but not those Involved in Pubertal Onset

Castro-Gonzalez David , Fuente-Martin Esther , Sanchez-Garrido Miguel A , Argente-Arizon Pilar , Tena-Sempere Manuel , Chowen Julie A , Argente Jesus

Background: Leptin is suggested to be a permissive factor in the onset of puberty by signaling at the level of the hypothalamus to indicate adequate energy stores. Overweight female rats due to increased neonatal nutrition have been shown to develop puberty before normal weight rats.Objective and hypothesis: We hypothesized that this permissive effect may be due not only to increased leptin levels, but also to increased hypothalamic sensitivity to this h...

hrp0089fc15.2 | Growth and Syndromes | ESPE2018

Effects of Caloric Restriction During Gestation on the Methylome of Offspring’s Adipose Tissue and Reversibility of Such Effects by Metformin in a Swine Model

Xargay-Torrent Silvia , Carreras-Badosa Gemma , Tibau Joan , Reixach Josep , Lizarraga-Mollinedo Esther , Mas-Pares Berta , Prats-Puig Anna , de Zegher Francis , Ibanez Lourdes , Lopez-Bermejo Abel

Introduction: Maternal caloric restriction during gestation leads to offspringÂ’s metabolic programming through epigenetic changes, which increase the risk of developing cardiovascular diseases in adulthood.Objectives: To study in a swine animal model: i) DNA methylation changes associated with caloric restriction during gestation in the adipose tissue of the offspring; and ii) the reversibility of these changes by metformin treatment.<p class="a...

hrp0092p2-127 | Fat, Metabolism and Obesity | ESPE2019

The bilirubin/triglycerides Ratio Predicts Changes over time in Glycated Hemoglobin in Prepubertal Healthy Children

Puerto-Carranza Elsa , Nuevo Casals Silvia , Roca Portella Berta , Xargay-Torrent Silvia , Lizarraga-Mollinedo Esther , Mas-Pares Berta , deZegher Francis , Ibañez Lourdes , Bassols Judit , Bermejo Abel López

Background: Low serum bilirubin and high serum triglycerides are independently associated with higher risk of developing metabolic syndrome. Both bilirubin and triglycerides can regulate insulin secretion and glucose uptake. This is a first longitudinal study in healthy children to associate bilirubin and the bilirubin/triglycerides ratio with metabolic markers.Objectives: Analyze independent associations between bilirub...

hrp0094p2-112 | Diabetes and insulin | ESPE2021

A single-centre evaluation of remote video consultation for children and young people with diabetes

Andrews Edward , Odeleye Esther , Kumaran Anitha , Trevelyan Nicola ,

Background: Throughout 2020 telemedicine was rapidly deployed across health services and, during the COVID-19 pandemic, replaced many face-to-face (FTF) medical consultations. Children and young people (CYP) with diabetes present a unique opportunity for this type of consultation, due to the ability to interpret and share glucose data via other platforms. This study describes both CYP and parent experience of a new telemedicine service for CYP with diabetes.</...

hrp0092p3-293 | Late Breaking Abstracts | ESPE2019

Clinical Evolution of a Patient with Isolated Growth Hormone Deficiency Type IA Treated with rIGF1 for 5 Years After The Development of GH-antibodies

Feliu Rovira Albert , Latorre Martinez Esther , Porcar Cardona Ines , Escribano Subias Joaquin

Introduction: Isolated growth hormone deficiency (IGHD) type IA causes a severe growth retardation. Their initial good response to exogenous GH is hampered by the development of anti-GH-antibodies leading to treat with IGF1 as the only therapeutic option. Here we present the evolution of a patient with IGHD type IA treated with IGF1r for more than 5 years.Description of the caseWe present a 5-year-...

hrp0086p1-p447 | Fat Metabolism and Obesity P1 | ESPE2016

Neonatal Overnutrition Causes Sex and Age Dependant Long-Term Effects on Body Weight, Body Composition and Serum Triglyceride and Free Fatty Acid Levels

Argente-Arizon Pilar , Diaz Francisca , Fuente-Martin Esther , Chowen Julie Ann , Argente Jesus

Background: Neonatal over-nutrition (NON) can increase the propensity to become overweight and develop associated metabolic disturbances in later life. Moreover, some of these long-term effects are sexually dimorphic.Objective and hypotheses: We aimed to determine how NON affects body weight (BW), body composition and triglyceride (TG) and non-esterified fatty acids (NEFA) levels. We hypothesized that the effects would be both age and sex dependant.<...

hrp0082p1-d1-110 | Fat Metabolism &amp; Obesity | ESPE2014

Free Fatty Acids Activate Hypothalamic Astrocytes in a Sexually Dimorphic Manner

Argente-Arizon Pilar , Fuente-Martin Esther , Diaz Francisca , Freire-Regatillo Alejandra , Argente Jesus , Chowen Julie A

Introduction: Obesity is known to associate with chronic systemic inflammation. However, hypothalamic inflammation also occurs in response to high fat diet (HFD)-induced obesity and is proposed to participate in central insulin/leptin resistance and the perpetuation of weight gain and systemic affectation. The weight gain and central responses to HFD differ between males and females. As hypothalamic glial cells are implicated in the central inflammatory response we hypothesize...

hrp0084p1-156 | Miscelleaneous | ESPE2015

Cushing Syndrome due to Adrenocortical Carcinoma in a 3-month-old Infant with a Large Interstitial Deletion of Chromosome 5q Including the APC Gene

Akkurt Halit Ilker , Schulz Esther , Reinshagen Konrad , Vater Inga , Caliebe Almuth , Johannsen Jessika

Background: Childhood adrenocortical tumours (ACT) are rare and have well been described as part of familial cancer susceptibility syndromes which are caused by single gene mutations including P53, MEN1, PRKAR1A, CTNNB1 and APC. Adenomas are the most common ACT, but adrenocortical carcinomas (ACC) occur as well. Childhood ACC can be part of the Li-Fraumeni Syndrome and Beckwith-Wiedemann syndrome. ACC can also occur in familial adenomatous polyposis coli (FAP). FAP is a colon ...

hrp0084p2-570 | Thyroid | ESPE2015

Goitrous Hypothyroidism of Pubertal Onset Caused by a Novel Mutation in DEHAL1 Gene

Schulz Esther , Iglesias Ainhoa , Akkurt Halit Ilker , Helmke Knut , Moreno Jose Carlos

Background: Iodotyrosine deiodinase (DEHAL1) is a thyroidal enzyme that deiodinates mono- and diiodtyrosines (MIT, DIT) and recycles iodine, essential for synthesis of thyroid hormone. Iodotyrosine deiodinase deficiency leads to hypothyroidism, goiter and variable mental retardation. The age for clinical onset was reportedly very diverse, allegedly related to individual iodine nutrition.Clinical case: We report on a boy, offspring of consanguineous paren...

hrp0084p3-588 | Adrenals | ESPE2015

Case Report: Hypothyroidism and Acth-Deficiency Caused by TBX 19 Mutation Coincidence or Pathogenetic Correlation?

Schulz Esther , Akkurt Halit Ilker , Muhlhausen Chris , Santer Rene , Welzel Maik , Holterhus Paul Martin

Background: Congenital isolated ACTH-deficiency is a rare disorder characterized by low plasma ACTH and cortisol levels and normal secretion of other pituitary hormones. TBX19 is a t-box transcription factor with a specific role in the differentiation of corticotroph cells. TPIT gene mutations can be found in early onset isolated ACTH deficiency.Case report: We report on a 2; 6 year old girl, offspring from consanguineous parents from Turkey, born at 40 ...