hrp0082p3-d3-942 | Puberty and Neuroendocrinology (1) | ESPE2014

A Severe LHRH-Independent Precocious Puberty in a 26-Month-Old Girl with a Clinical Diagnosis of McCune–Albright Syndrome

Flader Maciej , Latos-Bielenska Anna , Kapczuk Karina , Mankowski Przemyslaw , Malecka Elzbieta , Niedziela Marek

Background: Gonadal hyperfunction is the most frequent endocrine dysfunction in females with McCune–Albright syndrome (MAS), and precocious puberty (PP) is usually the first manifestation of MAS in children.Objective and hypotheses: The optimal pharmacologic treatment of PP in girls with MAS has not been yet identified and new therapeutic options like anti-estrogen should be taken under consideration especially in patients with extreme high estradio...

hrp0089p2-p350 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology P2 | ESPE2018

Psychological Gender Features and Social Abilities and in Adolescent Girls – Influence of Obesity and Hyperandrogenism

Zachurzok Agnieszka , Pasztak-Opilka Agnieszka , Forys-Dworniczak Elzbieta , Drosdzol-Cop Agnieszka , Gawlik Aneta , Malecka-Tendera Ewa

Background: Both, obesity and hyperandrogenism are the conditions that can influence many different health domains, also may affect the mental and social wellbeing components of subject’s life.Study objective: To evaluate whether body weight status and clinical hyperandrogenism may influence social competencies and psychological gender features in adolescent girls.Design & participants: In 104 adolescent girls clinical eva...

hrp0089p2-p141 | Fat, Metabolism and Obesity P2 | ESPE2018

Associations between Total Leptin, Bio-inactive Leptin, Soluble Leptin Receptor and Anthropometrics in Children with Severe Early-onset Obesity (SEOO) – the German-Polish Study (EOL-GPS)

Zachurzok Agnieszka , Malecka-Tendera Ewa , Petriczko Elzbieta , Mazur Artur , Pridzun Lutz , Flehmig Bertram , Schnurbein Julia von , Ranke Michael B. , Wabitsch Martin , Brandt Stephanie

Background: Severe early-onset obesity (SEOO) in children is more frequently observed in subjects with genetic disorders of which those of leptin pathway can be analyzed biochemically and genetically.Objectives: The aim of the study was to investigate anthropometrics and leptin parameters, specifically searching for bio-inactive leptin, in children with SEOO.Methods: Study cohort includes children ...

hrp0092p1-131 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology | ESPE2019

Is there the Relationship Between Anxiety and Depression Level and Clinical Presentation of Polycystic Ovary Syndrome in Adolescent Girls?

Zachurzok Agnieszka , Pasztak-Opilka Agnieszka , Malecka-Tendera Ewa

Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorder of the young women, and it could influence both physical and psychological wellbeing. As a consequence of obesity and hirsutism lower sexual attractiveness, higher emotional distress as well as higher depression score is frequently observed.Study Objective was to evaluate anxiety and depression score as well as the body esteem and stress perception ...

hrp0086p2-p383 | Gonads & DSD P2 | ESPE2016

Thyroid Autoimmunity in Adolescent Girls with Polycystic Ovary Syndrome – Pilot Study

Zachurzok Agnieszka , Skrzynska Karolina , Gawlik Aneta , Malecka-Tendera Ewa

Relationship between polycystic ovary syndrome (PCOS) and thyroid autoimmunity has been recently suggested by several authors. Autoimmune thyroiditis (AIT) is the most prevalent autoimmune disease and link between AIT and PCOS has been reported in adult women. There is a hypothesis that functional autoantibodies could contribute to the development of PCOS. The aim of the study was to evaluate the prevalence of thyroid autoimmunity in adolescent girls with PCOS. Forty five adol...

hrp0084p2-226 | Bone | ESPE2015

Association between Oxidative Stress and Bone Turnover Markers in the Obese Children

Matusik Pawel , Olszanecka-Glinianowicz Magdalena , Chudek Jerzy , Malecka-Tendera Ewa

Background: Recent data have been showed that free radicals are involved in either bone resorption and atherosclerosis development in adults. In paediatric population the important risk factor for the early atherosclerosis development is obesity, which can be also associated with the disturb bone turnover.Objective and hypotheses: The aim of the study was to evaluate the interrelationship between oxidative stress and bone turnover markers in obese childr...

hrp0082p3-d1-978 | Thyroid | ESPE2014

Treatment the Resistance to Thyroid Hormones in Girl

Budzynska Elzbieta , Ben-Skowronek Iwona , Korobowicz Elzbieta , Klatka Maria

Background: The cardinal feature of the resistance to thyroid hormone (RTH) is reduced responsiveness of target tissues to thyroid hormone action caused by thyroid hormone receptor β gene (THRB) mutations impairing hormone binding in the majority (90%) of cases. It results in elevated serum levels of free thyroxine (FT4) and triiodothyronine (FT3) associated with unsuppressed thyroid SH.Objective and hypotheses: The ai...

hrp0086p2-p766 | Pituitary and Neuroendocrinology P2 | ESPE2016

Congenital Craniopharyngioma: Report of Two Cases

Bogusz Agnieszka , Moszczynska Elzbieta , Szalecki Mieczyslaw

Introduction: Craniopharyngiomas are slow growing epithelial tumors located in the sellar or suprasellar region of the brain. Adamantinomatous subtype affects mainly children and accounts for 5–10% of all intracranial paediatric tumors. Diagnosed antenatal and neonatal craniopharyngiomas are very seldom, about 40 such cases have been detected to date. They are characterised by large size, progressive hydrocephalus and a poor prognosis.Aim: The aim o...

hrp0082fc13.5 | Thyroid | ESPE2014

The Ultrastructural Changes in Thyroid Cells in the Course of Damage in Hashimoto’s Thyroiditis

Ben-Skowronek Iwona , Szewczyk Leszek , Korobowicz Elzbieta

Background: The development of the Hashimoto’s thyroiditis is the result of the damage to thyrocytes, apoptosis, and autoimmune cytotoxic action of lymphocytes.Objective and Hypotheses: The aim of the study is to present ultrastructural changes in thyroid cells in the course of damage in Hashimoto’s thyroiditis.Method: The study involved 40 children: 20 children with Hashimoto’s thyroiditis and 20 children as a contr...

hrp0084p3-1125 | Pituitary | ESPE2015

Combined Pituitary Hormone Deficiency

Kot Karolina , Moszczynska Elzbieta , Szalecki Mieczyslaw

Background: Combined pituitary hormone deficiency (CPHD) may be congenital or acquired disorder, which affects more than one hormonal axis. Congenital hipopituitarism includes heterogenic group of disturbances. It may be result of mutations or deletions in genes for signaling and transcription factors responsible for pituitary development. The disorder might affect one or multiple family members. The age of appearance and intensity of the first hormone deficiency symptoms may ...