hrp0094hdi2.3 | How Do I Session 2 | ESPE2021

Advise patients on insulin dosing for real meals.

Pankowska Ewa ,

In Functional Intensive insulin therapy (FIIT), despite the using injection or continuous subcutaneous insulin infusion (CSII), the golden standard in meal insulin programing is carbohydrate food counting. On the other hand more and more study have shown how fat and protein meals raise postprandial glycaemia for long time than 3 hours. It was also observed that prolonged insulin delivery in normal and square-wave bolus for a mixed meal helps to normalize glycaemia profile if c...

hrp0089p3-p401 | Growth & Syndromes P3 | ESPE2018

Is Using a Specific Growth Charts a Chance to be More Precise in Evaluation the Growth of the Children and Adolescence with Down Syndrome? Comparison of the Down’s Syndrome Growth Charts with the Growth Charts for Polish Population

Barg Ewa , Hetman Marta

Introduction: Down syndrome (DS) is a chromosomal disorder. Children with DS have different height and weight patterns compared to children without DS. The aim of our study was to compare anthropometric parameters (expressed in standard deviation score-SDS) of people with DS using charts for DS and population (P) charts.Materials and Methods: The study group consisted of 114 patients with DS (64 girls), aged 4 months – 36 years (average age: 8.2 yea...

hrp0089p3-p414 | Adrenals and HPA Axis P3 | ESPE2018

Is the Third Time Really a Charm? The Story about Three Brothers Suffering from Adrenoleukodystrophy and about HSCT being a Chance to Stop the Unstoppable Disease

Hetman Marta , Kalwak Krzysztof , Barg Ewa

Introduction: Adrenoleukodystrophy (ALD) is a genetic diseases classified in the group of peroxisomal disorders caused by mutations in ABCD1, a gene located on the X chromosome. It is the most common monogenetically inherited neurodegenerative diseases. X-ALD is an inborn error of metabolism characterized by impaired peroxisomal beta-oxidation of very long-chain fatty acids (VLCFA) with a heterogeneous clinical spectrum. VLCFA accumulate principally in the CNS...

hrp0092p1-131 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology | ESPE2019

Is there the Relationship Between Anxiety and Depression Level and Clinical Presentation of Polycystic Ovary Syndrome in Adolescent Girls?

Zachurzok Agnieszka , Pasztak-Opilka Agnieszka , Malecka-Tendera Ewa

Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorder of the young women, and it could influence both physical and psychological wellbeing. As a consequence of obesity and hirsutism lower sexual attractiveness, higher emotional distress as well as higher depression score is frequently observed.Study Objective was to evaluate anxiety and depression score as well as the body esteem and stress perception ...

hrp0086p2-p383 | Gonads & DSD P2 | ESPE2016

Thyroid Autoimmunity in Adolescent Girls with Polycystic Ovary Syndrome – Pilot Study

Zachurzok Agnieszka , Skrzynska Karolina , Gawlik Aneta , Malecka-Tendera Ewa

Relationship between polycystic ovary syndrome (PCOS) and thyroid autoimmunity has been recently suggested by several authors. Autoimmune thyroiditis (AIT) is the most prevalent autoimmune disease and link between AIT and PCOS has been reported in adult women. There is a hypothesis that functional autoantibodies could contribute to the development of PCOS. The aim of the study was to evaluate the prevalence of thyroid autoimmunity in adolescent girls with PCOS. Forty five adol...

hrp0082p2-d3-405 | Fat Metabolism & Obesity (2) | ESPE2014

Do Children with Down Syndrome Show Lipid Profile Disorders?

Zimny Dominika , Szatkowska Marta , Maciaszek Julian , Machaj Mikolaj , Barg Ewa

Background: People with Down syndrome (DS) are considered to be atherosclerosis-free. However, obesity predispositions and thyroid gland dysfunction that accompanies this syndrome can influence on the heart ischemic risk. The aim of the study was the evaluation of lipid profile of children with DS and estimation of omega-3 supplementation effect on serum lipid profile.Materials and methods: The group constituted 69 children with DS (41 boys), average age...

hrp0082p3-d1-772 | Fat Metabolism & Obesity | ESPE2014

Do Children with Down Syndrome Show Lipid Profile Disorders?

Zimny Dominika , Szatkowska Marta , Maciaszek Julian , Machaj Mikolaj , Barg Ewa

Background: People with Down syndrome (DS) are considered to be atherosclerosis-free. However, obesity predispositions and thyroid gland dysfunction that accompanies this syndrome can influence on the heart ischemic risk.Aim: The aim of the study was the evaluation of lipid profile of children with DS and estimation of omega-3 supplementation effect on serum lipid profile.Materials and methods: The group constituted 69 children wit...

hrp0084p2-226 | Bone | ESPE2015

Association between Oxidative Stress and Bone Turnover Markers in the Obese Children

Matusik Pawel , Olszanecka-Glinianowicz Magdalena , Chudek Jerzy , Malecka-Tendera Ewa

Background: Recent data have been showed that free radicals are involved in either bone resorption and atherosclerosis development in adults. In paediatric population the important risk factor for the early atherosclerosis development is obesity, which can be also associated with the disturb bone turnover.Objective and hypotheses: The aim of the study was to evaluate the interrelationship between oxidative stress and bone turnover markers in obese childr...

hrp0092p1-41 | Fat, Metabolism and Obesity | ESPE2019

Growth Arrest-Specific 6 (Gas6) Protein is Associated with Adiposity and Metabolic Syndrome in Obese Children and Adolescents

Zajdel-Cwynar Olimpia , Matusik Pawel , Olszanecka-Glinianowicz Magdalena , Malecka-Tendera Ewa

Introduction: Growth arrest-specific 6 (Gas6) is a vitamin K-dependent protein produced by several types of cells including adypocytes and regulates their homeostasis. Previous studies indicate that Gas6 signaling may be involved in the pathogenesis of obesity and its complications, including systemic inflammation and insulin resistance. However, little is known about the clinical significance of the Gas6 system in childhood obesity. The aim of the study was t...

hrp0092p1-373 | Growth and Syndromes (to include Turner Syndrome) (2) | ESPE2019

Matrix Metalloproteinases, their Inhibitors and Neurotrophic Factors as Indicators of Cardiometabolic Risk in Turner Syndrome Girls

Blaszczyk Ewa , Lorek Milosz , Francuz Tomasz , Gieburowska Joanna , Tokarska Agnieszka , Gawlik Aneta

Context: Turner syndrome (TS) predisposes to obesity and related disorders being a part of the metabolic syndrome. As TS population is at a higher risk of cardiovascular diseases research for laboratory markers of metabolic complications is ongoing. Based on our previous observation special significance is attributed to MMPs (matrix metalloproteinases), their inhibitors TIMPs and neurotrophic factors, such as BDNF (Brain-Derived Neurotrophic Factor) and GDNF (...