hrp0094p1-70 | Diabetes B | ESPE2021

Change in HbA1C predicts future abnormal Oral Glucose Tolerance Tests in children and adolescents with Cystic Fibrosis.

Aftab Sommayya , Ghauri Rooha Ijaz , Drew Samantha , Meek Hannah , Peters Catherine , Amin Rakesh ,

Background: Oral glucose tolerance test (OGTT) is the screening test of choice for Cystic Fibrosis Related Diabetes (CFRD). HbA1C is considered unreliable in diagnosing CFRD because of increased cell turn over in children and adolescents with Cystic Fibrosis (CF).Objective: To determine the validity of HbA1C as a predictive tool for future abnormal OGTT in CF.Material & Methods: Data were colle...

hrp0089p2-p107 | Diabetes & Insulin P2 | ESPE2018

Congenital Hyperinsulinism in a Child with Alagille Syndrome

Khan Durray Shahwar , Dastamani Antonia , Antell Hannah , Shah Pratik

Background: Alagille syndrome (ALGS) is an autosomal dominant genetic disorder, with highly variable phenotype affecting multiple organs. Commonly presents in infancy or early childhood as cholestasis. Mutations in the notch signaling pathway ligand (JAG1) or its receptor (NOTCH2) lead to ALGS. This pathway is important for the pancreatic development. However,no cases of ALGS with Congenital Hyperinsulinism (CHI) have been reported to date.<p class="abste...

hrp0094p1-139 | Growth Hormone and IGFs A | ESPE2021

The effect of growth hormone therapy on linear growth and weight gain in children with growth hormone deficiency vs idiopathic short stature (ISS) a controlled study

Elsiddig Sohair , Soliman Ashraf , Alaaraj Nada , Khalil Ahmed , Ahmed Hannah ,

Introduction: Controversy still exists about the effect of GH treatment on linear growth and weight gain (WG) in children with ISS.Aim: To study linear growth and weight gain in children with ISS treated with GH vs those not treated in comparison with treated children with GHD.Methodology: We conducted a longitudinal controlled study on 78 children presented to a pediatric clinic with short stature...

hrp0094p1-140 | Growth Hormone and IGFs A | ESPE2021

Linear growth response top Growth hormone therapy in underweight versus normal-weight children with idiopathic short stature (ISS).

Elsiddig Sohair , Soliman Ashraf , Alaaraj Nada , Khalil Ahmed , Ahmed Hannah ,

Introduction: A multicenter clinical trial in the US showed that underweight small for gestation (SGA) children responded to GH treatment like non-underweight SGA children. However, data on GH response in short underweight children with the normal birth size is not studied well.Aim: To measure growth response to GH therapy in underweight children versus short normal-weight children with idiopathic short stature (ISS) bor...

hrp0094p1-178 | Growth Hormone and IGFs B | ESPE2021

Study on linear growth of children with idiopathic short children (ISS) with Low Insulin-like growth factor 1 (IGFI) at diagnosis: Growth hormone (GH) treatment versus no treatment.

Elsiddig Sohair , Soliman Ashraf , khalil Ahmed , Alaaraj Nada , Ahmed Hannah ,

ISS is a condition in which the height of the individual is more than 2SD below the corresponding mean height for a given age, sex, and population, in whom no identifiable disorder is present. At presentation, some of these children have relatively low IGF-I levels which theoretically can affect their response to GH therapy. The question is: does GH treatment of these children improve their linear growth compared to no treatment?Aim: We ...

hrp0094p2-255 | Growth hormone and IGFs | ESPE2021

Prevalence of insulin-like growth factor 1 (IGF1) deficiency in prepubertal children with isolated short stature (ISS) and their response to GH therapy.

Elsiddig Sohair , Soliman Ashraf , Khalil Ahmed , Alaaraj Nada , Ahmed Hannah ,

Background/aims: Primary IGF1 deficiency (IGFD)’ is defined by low levels of IGF1 without a concomitant impairment in GH secretion in the absence of secondary cause. The aims of this study were to evaluate the prevalence of non-GH deficient IGFD in prepubertal children with isolated short stature (SS) and to describe their response to GH therapy.Methods: This retrospective study included all children with isolated S...

hrp0094p2-256 | Growth hormone and IGFs | ESPE2021

Thyroid function (TF) in short children with idiopathic short stature (ISS) treated with growth hormone (GH)versus those not treated; a controlled study.

Elsiddig Sohair , Soliman Ashraf , Alaaraj Nada , Khalil Ahmed , Ahmed Hannah ,

In ISS is a condition with a height is >2SD below the corresponding mean for age, sex, and population. Thyroid abnormalities reported during GH therapy in GH deficient (GHD) children but not well studied in ISS children on GH therapy.Aim: To investigate effects of GH therapy on TF in a group of euthyroid children with ISS in comparison with ISS group not receiving GH therapy and GHD group on GH therapy.Material...

hrp0094p2-264 | Growth hormone and IGFs | ESPE2021

Growth hormone (GH) treatment of children with idiopathic short children (ISS) with normal insulin-like growth factor-1 (IGF-1) versus those with low IGF-I at diagnosis.

Elsiddig Sohair , Soliman Ashraf , Alaaraj Nada , Khalil Ahmed , Ahmed Hannah ,

ISS is a condition in which the height is more than 2 SD below the corresponding mean height for age, sex and population, in whom no identifiable disorder is present. Some ISS patients may have varying degrees of IGF-1 deficiency. Recombinant GH treatment has been used by some authors with variable results. Theoretically, low IGF-I level at presentation may affect their response to GH therapy. The question is: do children with ISS and low IGF-I respond differently to GH therap...

hrp0094p2-265 | Growth hormone and IGFs | ESPE2021

Growth response to growth hormone therapy in growth hormone deficient (GHD) children in relation to the distance between their height SDS (HtSDS) and their mid-parental height.

Elsiddig Sohair , Soliman Ashraf , Alaaraj Nada , Khalil Ahmed , Ahmed Hannah ,

Introduction: Mid-parental height (MPH) is a useful tool in the prediction of final adult height in normal children as well as those on growth hormone (GH) therapy. Aim of the study to evaluate the growth response to GH therapy in GHD children in relation to their MPH.Methods: This retrospective study included 22 short prepubertal children with GHD (peak GH<10 μg/l). They were followed in the Endocrine clinic be...

hrp0094p2-266 | Growth hormone and IGFs | ESPE2021

Linear growth and response to GH therapy in children with short stature with normal Growth hormone secretion: Comparison between children with delayed versus no delay in the bone age at diagnosis.

Elsiddig Sohair , Soliman Ashraf , Alaaraj Nada , khalil Ahmed , Ahmed Hannah ,

Bone age (BA) continues to be a valuable tool in assessing children’s growth potential. Children with normal variant short stature can be subdivided into idiopathic short stature (ISS) (with no delay in BA versus chronological age (CA) and constitutional delay (CDG) (with delayed BA versus CA. The response of these two groups to GH therapy remains controversial.Aim, patients, and methods: We studied linear growth, weight gain, skeletal maturation, a...