hrp0094yb1.4 | Year of Paediatric Endocrinology 1 | ESPE2021

Growth and Growth Factors

Cianfarani Stefano , Inzaghi Elena , Pampanini Valentina , Fintini Danilo ,

Long-term safety of rhGH therapy in childhood has been object of intense investigation in the last decade. Two recent observational studies have focused on the risk of cardiovascular diseases in young adults treated with rhGH during childhood. After subdividing the large cohorts of patients in different risk groups they found that both mortality and morbidity from cardiovascular diseases were higher than the general population in the low risk group including patients with isol...

hrp0089p1-p238 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology P1 | ESPE2018

Effect of Intrauterine Growth Restriction on Ovarian Follicle Pool

Pampanini Valentina , Germani Daniela , Puglianiello Antonella , Jahnukainen Kirsi , Sahlin Lena , Cianfarani Stefano , Soder Olle

Introduction: A low oxygen and/or nutrient supply to the fetus, resulting in intrauterine growth restriction (IUGR), can affect gonadal development of the offspring and have a potential impact on fertility. Epidemiological studies on subjects born small for gestational age (SGA), as a surrogate measure of IUGR, have reported contradictory results. Data derived from animal models of placental insufficiency are limited.Objective and hypotheses: To investig...

hrp0086fc4.3 | Pathophysiology of Obesity | ESPE2016

Expression of Type 1 Insulin-like Growth Factor Receptor (IGF-1R) in Liver of Obese Children with Non-alcoholic Fatty Liver Disease (NAFLD)

Pampanini Valentina , De Stefanis Cristiano , Alisi Anna , Inzaghi Elena , Nobili Valerio , Cianfarani Stefano

Background: Type 1 insulin-like growth factor receptor (IGF-1R) is the product of a single-copy gene located on chromosome 15 and is ubiquitously expressed in humans. Increased hepatic IGF-1R gene expression is found in hepatocellular carcinoma and in chronic hepatitis C, making parenchymal and non-parenchymal cells more susceptible to the mitogenic effects of IGF-1.Objective and hypotheses: As we have previously demonstrated that IGF-1 and IGF-2 circula...

hrp0082p2-d2-383 | Fat Metabolism & Obesity (1) | ESPE2014

Fetuin A Serum Levels in Children with Nonalcoholic Fatty Liver Disease

Pampanini Valentina , Inzaghi Elena , Nobili Valerio , Germani Daniela , Puglianiello Antonella , Cianfarani Stefano

Background: Fetuin A is a hepatokine known as a natural inhibitor of the insulin receptor tyrosine kinase and is associated with insulin resistance and nonalcoholic fatty liver disease (NAFLD). Studies on adults provided conflicting results regarding the link between fetuin A and the severity of liver damage in NAFLD. Data on children are limited.Objective: To investigate the relationship between fetuin A, metabolic parameters, and NAFLD in obese childre...

hrp0082p2-d1-415 | Growth Hormone | ESPE2014

IGF1 is Associated with a More Favourable Pattern of Body Composition in Obese Children

Inzaghi Elena , Pampanini Valentina , Alessio Paola , Fiori Rossana , Ferroli Barbara Baldini , Cianfarani Stefano

Background: Recent studies have suggested a role of IGF1 as a candidate prognostic marker for cardiometabolic complications of obesity.Objective: To investigate the relationship between IGF1 serum levels and both biochemical and metabolic parameters as well as body composition in a cohort of obese children.Methods: obese subjects (130F/157M), aged 11.2±2.7 years, were studied. Anthropometry, biochemical and metabolic parameter...

hrp0086p1-p340 | Gonads & DSD P1 | ESPE2016

Intrauterine Growth Restriction Affects Postnatal Testis Maturation in Rats

Pampanini Valentina , Germani Daniela , Puglianiello Antonella , Stukenborg Jan-Bernd , Reda Ahmed , Savchuk Iuliia , Kjartansdottir Ros , Cianfarani Stefano , Soder Olle

Background: The influence of intrauterine life on long term health is supported by a wealth of epidemiological and experimental studies. A low oxygen and/or nutrient supply to the fetus, resulting in intrauterine growth restriction (IUGR), may affect gonadal development of the offspring, with a potential impact on fertility. Data derived from animal models of placental insufficiency are very limited.Objective and hypotheses: To investigate the effects of...

hrp0082p2-d1-517 | Pituitary | ESPE2014

Could Brain MRI Replace GH Stimulation Tests in the Work-Up of GH Deficiency in the First Years of Life?

Pedicelli Stefania , Scire Giuseppe , Pampanini Valentina , Gubinelli Jessica , Spadoni Gian Luigi , Bitti Maria Luisa Manca , Cappa Marco , Boscherini Brunetto , Cianfarani Stefano

Background: Currently, the diagnosis of GH deficiency (GHD) in infants and young children is based on the assessment of GH serum levels either during hypoglycaemia or after pharmacological stimulation tests. However, GH cut-off values have not been standardized and provocative tests may be unsafe in this age range.Objective and hypotheses: Brain MRI may replace GH measurements in diagnosing GHD in infancy and young childhood.Method...

hrp0094yi1.2 | Young Investigators | ESPE2021

Early life events and postnatal effects from infancy to childhood

Chiavaroli Valentina ,

Early life events can profoundly affect an individual’s metabolic phenotype, inducing adaptive responses that may be protective in utero but potentially disadvantageous for long-term health. Indeed, environmental cues during sensitive windows of development may result in altered growth and lead to an increased risk of cardiovascular and metabolic alterations later in life. In this talk, I will discuss several models of exposure to early life events, which were th...

hrp0089p3-p153 | Fat, Metabolism and Obesity P3 | ESPE2018

Resting Metabolic Rate and the Development of Metabolic Disorders in Obese Children

Okorokov Pavel , Vasyukova Olga , Shiryaeva Tatiana , Peterkova Vanentina

Decreased resting metabolic rate (RMR) is a risk factor for the development and progression of obesity. Childhood obesity is accompanied by the development of metabolic disorders, which often persist in adults. The relationship between the rate of basal metabolism and development of childhood obesity complications is not well understood.Objective and hypotheses: Measure resting metabolic rate in obese children and assess the pronouncement of metabolic di...

hrp0089p3-p133 | Fat, Metabolism and Obesity P3 | ESPE2018

Nonclassical Manifestation of PWS

Bogova Elena , Volevodz Natalya , Peterkova Valentina

Background: Prader-Willi syndrome (PWS) is a complex, multisystem disorder and is the most frequent cause of syndromic obesity that arises from lack of expression of paternally inherited imprinted genes on chromosome 15q11-q13. Its major clinical features include neonatal hypotonia, short stature, developmental delay, behavioral abnormalities, hyperphagia, childhood onset obesity, hypothalamic hypogonadism, and characteristic appearance.Case history: We ...