hrp0082p1-d1-146 | Growth | ESPE2014

Analysis of GH Receptor Gene Expression in Idiopathic Tall Stature Children

Pagani Sara , Radetti Giorgio , Meazza Cristina , Bozzola Mauro

Background: Growth is a multifactorial process involving genetic, nutritional and other environmental determinants. Because of a major proportion of ultimate stature is dependent upon an intact GH and IGF1 axis, much attention has been devoted to abnormalities related to these growth factors and their signalling pathways.Objective and hypotheses: At the tissue level, the action of GH result from the interaction of GH with a specific cell surface GH recep...

hrp0092p3-267 | Late Breaking Abstracts | ESPE2019

Indexes of Adiposity and Body Composition in the Prediction of Metabolic Syndrome in Obese Children and Adolescents: Which is the Best

Lupi Fiorenzo , Longhi Silvia , Radetti Giorgio , Fanolla Antonio , Grugni Graziano , Sartorio Alessandro

Objective: There is no agreement about which index of adiposity and/or body composition is the most accurate in identifying the metabolic syndrome (METS). The aim of our study was to compare the accuracy of the different indexes in order to recognize the most reliable.Study Design: We evaluated 1332 obese children and adolescents (778 females and 554 males), aged 14.4 ± 1.8 yrs., Body Mass Index (BMI) standard devia...

hrp0086p2-p835 | Syndromes: Mechanisms and Management P2 | ESPE2016

Turner Syndrome: Does GH Treatment Influence Glucose Homeostasis?

Baronio Federico , Lupi Fiorenzo , Girtler Ylenia , Tamburrino Federica , Maltoni Giulio , Scarano Emanuela , Mazzanti Laura , Radetti Giorgio

Background: Growth hormone (GH) has been shown to reduce insulin sensitivity in Turner girls, however a compensatory increase of insulin secretion by pancreatic beta cells usually occurs, probably stimulated by GH itself. Oral disposition index (ODI) express the capacity of beta cells to adapt to insulin sensitivity.Objective and hypotheses: To study longitudinally the insulin sensitivity (HOMA-S), the insulin secretion (IGI) and the ODI in a group of gi...

hrp0082p1-d1-68 | Diabetes | ESPE2014

Evaluation of Bone Geometry, Quality, and Bone Markers in Children with Type 1 Diabetes

Longhi Silvia , Franceschi Roberto , Cauvin Vittoria , Gallo Giuseppe , Lupi Fiorenzo , Reinstadler Petra , Radetti Giorgio

Background: Several studies have examined the relationship between type 1 diabetes and bone mass, which reported contradictory data on BMD, bone remodelling markers, and bone quality. Nevertheless an incresead prevalence of osteopenia was observed among patients with duration of disease of >6 years.Objective and hypotheses: The aim of the study was to investigate the potential negative impact of type 1 diabetes on bone status in a group of children w...

hrp0082p1-d1-204 | Reproduction | ESPE2014

The Influence of GH Treatment on the Oral Disposition Index in Turner Syndrome Girls and in GH Deficient Children: 8 Years of Follow-Up

Baronio Federico , Lupi Fiorenzo , Siroli Benedetta , Longhi Silvia , Tamburrino Federica , Scarano Emanuela , Mazzanti Laura , Radetti Giorgio

Background: GH has been shown to influence glucose homeostasis through a negative effect on insulin sensitivity followed by a compensatory increase of insulin secretion. However it has been recently reported, in animals and in humans, that GH might stimulate insulin secretion also through a direct effect on the growth and on the function of the pancreatic β cell.Objective and hypotheses: To study longitudinally the insulin sensitivity (HOMA-S), the ...

hrp0084p3-641 | Bone | ESPE2015

Evaluation of Bone Geometry, Quality and Bone Markers in Children with Type 1 Diabetes

Longhi Silvia , Franceschi Roberto , Cauvin Vittoria , Gallo Giuseppe , Lupi Fiorenzo , Reinstadler Petra , Radetti Giorgio

Background: Several studies have examined the relationship between type 1 diabetes and bone mass, which reported contradictory data on BMD, bone remodelling markers and bone quality. Nevertheless an incresead prevalence of osteopenia was observed among patients with duration of disease of >6 years.Objective and hypotheses: The aim of the study was to investigate the potential negative impact of type 1 diabetes on bone status in a group of children wi...

hrp0084p3-1198 | Thyroid | ESPE2015

Thyroid Function in a Large Group of Obese Children: Causes and Consequences

Lupi Fiorenzo , Radetti Giorgio , Longhi Silvia , Grugni Graziano , Marazzi Nicoletta , Fanolla Antonio , Sartorio Alessandrio

Background: Mild TSH elevations are frequently observed in obese patients, in the absence of any detectable thyroid disease.Aims and objective: To evaluate possible causes for the raised TSH levels and to verify possible biochemical and clinical consequences of this condition.Methods: We evaluated 779 (325 males/454 females) obese children, chronological age 14.38±2.56 (range 5.25 to 18.50), height SDS 0.27±1.04 (range &#...

hrp0082p2-d3-443 | Growth Hormone (2) | ESPE2014

The Effect of Two Different GH Dosages on Final Height and Bone Geometry

Lupi Fiorenzo , Bozzola Mauro , Buzi Fabio , Longhi Silvia , Mascolo Amelia , Pilotta Alba , Porto Rossella , Ruffinazzi Giulia , Zattoni Valentina , Radetti Giorgio

Background: GH has a strong positive influence on bone stimulating both bone elongation and increase in size by enhancing the accrual of trabecular and cortical bone up to the attainment of peak bone mass in young adult.Aim of the study: We compared the effect of two different GH dosages on statural growth and bone geometry in two groups of GH-deficient children at final height. Data has been collected retrospectively from 1994 to 2013.<p class="abst...

hrp0084p2-565 | Thyroid | ESPE2015

Metamorphic Thyroid Autoimmunity in Down Syndrome: From Hashimoto’s Thyroiditis to Graves’ Disease and Beyond

Aversa Tommaso , Valenzise Mariella , Salerno Mariacarolina , Corrias Andrea , Iughetti Lorenzo , Radetti Giorgio , De Luca Filippo , Wasniewska Malgorzata

Background: During the last years, it has been sporadically reported that Graves’ disease (GD) and Hashimoto’s thyroiditis (HT) may follow one another in the same individuals, due to a sequential phenotypic conversion from GD to HT or vice versa.Objective and hypotheses: To shed further light on the specific relationships between Down syndrome (DS) and metamorphic thyroid autoimmunity.Method: We have reconstructed the con...

hrp0086p1-p614 | Growth P1 | ESPE2016

Serum α-Klotho Levels are not Informative for the Evaluation of GH Secretion in Short Children

Elsedfy Heba , Meazza Cristina , Radetti Giorgio , Khalaf Randa I. , Pagani Sara , Sessa Nicodemo , Albertini Riccardo , De Stefano Anna Maria , Navarra Antonella , Lupi Fiorenzo , El Kholy Mohamed , Bozzola Mauro

Background: α-klotho is a transmembrane protein which can be cleaved and act as a circulating hormone. Since low α-klotho levels were found in organic GH deficiency (GHD) and high levels in acromegaly, an interaction between α-klotho, GH and linear growth has been suggested.Objective and hypotheses: We investigated the role of α-klotho protein as a reliable marker of GH secretion in short children and the factors influencing its secre...