hrp0092p3-112 | Fat, Metabolism and Obesity | ESPE2019

Insulin Resistance in Children and Adolescents with Exogen-Constitutional Obesity

Azimova Shakhnoza , Rakhimova Gulnara

Objective: evaluate insulin resistance (IR) in children and adolescents with exogen-constitutional obesity (ECO) depending on the stage of sexual development.Materials and research methods: 100 children and adolescents with ECO of the UzBek population from 6 to 16 years were observed (mean age 11.7 ± 0.25 years). The control group consisted of 71 healthy children of the appropriate age (mean age 11.1 ± 0.33 yea...

hrp0086p1-p207 | Diabetes P1 | ESPE2016

Interrelation between ACE Gene I/D Polymorphism and Chronic Kidney Disease Severity in Uzbek Children and Adolescents with Type 1 Diabetes Mellitus

Rakhimova Gulnara , Sadykova Akida

Background: Generally, diabetic nephropathy onsets and progresses within 5–10 years after DM onset resulting in chronic kidney disease (CKD) causing death in every 4–5th patient with type I DM. Molecular-genetic studies of endogenous/genetic CKD risk factors are of high relevance in understanding of pathogenetic mechanisms underlying formation of nephrosclerosis, and in improvement of interventions.Objective and hypotheses: To assess renal func...

hrp0082p2-d1-328 | Diabetes | ESPE2014

Functional Condition of the Kidneys (K/DOQI, 2002) By ACE Gene I/D Polymorphism in Children and Adolescents with Type I Diabetes Mellitus

Sadykova Akidahon , Rakhimova Gulnara

Objective and hypotheses: The work was initiated to assess functional condition of the kidneys and to study interrelation between ACE gene I/D polymorphism and stage of chronic kidney disease in children and adolescents with type 1 diabetes mellitus (DM) in compliance with K/DOQI recommendations (2002).Method: We examined 120 children and adolescents with type 1 DM, 53 (44.2%) males and 67 (55.8%) females among them (mean age 13.8±0.24 years. GFR wa...

hrp0082p2-d3-559 | Puberty and Neuroendocrinology (2) | ESPE2014

The Buserelin Stimulation Test Given as an Intranasal Spray in Diagnosing Gonadotropin Deficiency in Males with Delayed Puberty

Rakhimova Gulnara , Gilyazetdinov Kamil

Background: Because of episodic secretion of gonadotropins (LH, and FSH), basal levels of these hormones can not objectively be assessed to differentiate delayed puberty in males.Objective and hypotheses: To assess the efficacy of the GnRH agonist (as spray) in diagnosing of delayed puberty in males.Method: Prepubertal males (n=18; age range 13.3–18.5 years) were studied; buserelin 0.15 (spray) μg was administere...

hrp0082p3-d2-785 | Fat Metabolism & Obesity (1) | ESPE2014

Prevalence of Excessive Body Mass and Obesity Among Children and Adolescents Residing in Tashkent, Uzbekistan

Azimova Shakhnoza , Rakhimova Gulnara

Background: Having the onset in childhood or adolescence obesity in one third of adult people is known to progress resulting in complications. A number of studies demonstrated preservation of excessive weight in 80% of obese adolescents.Objective and Hypotheses: The work was initiated to analyze prevalence of excess body mass and obesity among children and adolescents residing in Tashkent, Uzbekistan.Method: We examined 3140 childr...

hrp0084p3-708 | Diabetes | ESPE2015

Incidence and Risk Factors of Diabetic Nephropathy in Children and Adolescents as Per Republic of Uzbekistan National Register

Rakhimova Gulnara , Alimova Nasiba

Aim: To study incidence and risk factors of diabetic nephropathy (DN) in children and adolescents as per the Republic of Uzbekistan National Register.Method: An information list (card) and appropriate software were developed on the basis of the DN register. The cards were collected in every region of Uzbekistan to be introduced into a computer database.Results: DN screening performed in children by Alikhanova N M in 1998 showed tha...

hrp0084p3-738 | Diabetes | ESPE2015

Prestarium Pharmacogenetic Efficacy in Predicting Diabetic Nephropathy in Children and Adolescents

Rakhimova Gulnara , Sadikova Akida

Aim: The work was initiated to study efficacy of prestarium in normoalbuminuric patients with type 1 diabetes mellitus by ACE genotype upon primary diabetic nephropathy (DN) prevention.Materials and methods: We examined normoalbuminuric 22 patients with type 1 diabetes mellitus aged from 12 to 17 years with DN duration ≧ 10 years divided into two groups by ACE polymorphism, that is, the one with II genotype (n=11) and the one with DD geno...

hrp0084p3-926 | GH & IGF | ESPE2015

Usefulness of Priming with Gonadal Steroids Prior to GH Stimulation with Clonidine in the Evaluation of the GH Status of Short Children

Rakhimova Gulnara , Gilyazetdinov Kamil

Aim: To determine the usefulness of priming with gonadal steroids prior to GH stimulation with clonidine in the evaluation of the GH status of short children.Method: 21 males were studied, with a mean chronological age of 13.2±1.5 years (range 11–16 years), mean bone age 11.0±1.4 years, Tanner stage 1–2, with height 135.8±7.4 cm (Ht-SDS −2.8±0.5), and an inadequate response to an initial GH stimulation test with clonid...

hrp0092p2-89 | Diabetes and Insulin | ESPE2019

The Prevalence of Chronic Kidney Disease in Children and Adolescents with Type 1 Diabetes Mellitus in The Republic of Uzbekistan

Rakhimova Gulnara , Sadikova Akidahon

Chronic kidney disease (CKD) is one of the most significant medical and socio-economic problems of our time.Purpose of the Research: To study the prevalence of chronic kidney disease in children and adolescents with type 1 diabetes in Uzbekistan.Materials and Methods: For conducting epidemiological studies there were examined children and adolescents of type 1 diabetes. Epidemiological data were st...

hrp0082p1-d1-60 | Diabetes | ESPE2014

Activity of Neutral Alfa-Glucosidase in the Urine of Children and Adolescents with Type 1 Diabetes Mellitus and Diabetic Nephropathy

Sadykova Akidahon , Rakhimova Gulnara

Aim: To identify clinical significance of enzymuria in early diagnosis of DN in children and adolescents with type 1 diabetes mellitus.Materials and methods: We examined 112 patients (47males/55 females) with type 1 diabetes mellitus. By the DN severity the patients were divided into following groups: with normoalbuminuria (NAU) (n=47), with microalbuminuria (MAU) (n=44) and with marked proteinuria (MP) (n=19). Ten healthy subj...