hrp0092p3-48 | Diabetes and Insulin | ESPE2019

Oral Glucose Tolerance Test (OGTT) as a Useful Tool for Early Diagnosis of Type 2 Diabetes Mellitus and Prediction of Metabolic Risks in Children and Adolescents

Kostopoulou Eirini , Tikka Maria , Rojas Gil Andrea Paola , Partsalaki Ioanna , Spiliotis Bessie

Objective: Type 2 Diabetes Mellitus(T2DM)and obesity represent two major health hazards in children and adolescents, with rising prevalence. Several markers have been developed in order to diagnose T2DM and detect potential metabolic abnormalities.The objective of the study was to examine glucose tolerance in Greek children and adolescents and the differences in the glucose, insulin and c-peptide response curves between male and female children and adolescents...

hrp0092p3-68 | Diabetes and Insulin | ESPE2019

Seasonal Variation and Epidemiological Parameters in Children from Western Greece with Type 1 Diabetes Mellitus (T1DM)

Kostopoulou Eirini , Papachatzi Eleni , Skiadopoulos Spyros , Rojas-Gil Andrea-Paola , Spiliotis Bessie

Introduction: A positive correlation between the onset of T1DM and winter has been suggested by studies conducted in different countries.Objective: To investigate the seasonal variation of T1DM diagnosis and additional epidemiological parameters in children from Western Greece diagnosed with T1DM.Methods: 105 patients, 44 males and 61 females, aged 1 to 16 years (mean: 8.2±4 y...

hrp0094p1-35 | Fat, Metabolism and Obesity A | ESPE2021

The possible association of the apoptotic marker APO1/Fas with predisposition to metabolic syndrome and mean platelet volume in children

Kostopoulou Eirini , Katsa Maria Efthymia , Magana Maria , Ioannidis Anastasios , Chatzipanagiotou Stylianos , Sachlas Athanasios , Spiliotis Bessie , Rojas Gil Andrea Paola ,

Objective: To investigate the possible relationship between APO1/Fas, components of metabolic syndrome and Mean Platelet Volume (MPV) in a healthy pediatric population.Study design: 185 children, aged 5-17 years old, were enrolled to the study. The participants were divided intο subgroups according to age and body mass index percentile (BMI%). APO1/Fas was measured by ELISA and MPV by the MEK-6410K.Re...

hrp0089p1-p240 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology P1 | ESPE2018

Serum Anti-Mullerian Hormone (AMH) concentrations and Reduced Appendix Testis Estrogen Receptor Expression in Cryptorchidism

Panagidis Antonios , Kourea Helen , Sinopidis Xenophon , Kostopoulou Eirini , Rojas-Gil Andrea Paola , Skiadopoulos Spyridon , Georgiou George , Spiliotis Bessie E.

Objective: AMH causes fetal paramesonephric duct regression and is involved in testicular development and function. Sertoli cell AMH remains high during childhood until puberty. The appendix testis (AT), a remnant of the paramesonephric duct, contains both androgen and estrogen receptors. AT androgen receptors have been reported to play a role in embryonic testicular descent. The AT is commonly resected during orchiopexy and abdominal surgery as possible torsion in the future ...

hrp0094p1-92 | Thyroid A | ESPE2021

Emotional Intelligence scores in children and adolescents with subclinical hypothyroidism - correlation with serum serotonin and thyroid stimulating hormone (TSH) concentrations.

Kostopoulou Eirini , Arianas George , Ioannidis Anastasios , Dimopoulos Ioannis , Chiotis Christos , Prezerakos Panagiotis , Spiliotis Bessie , Rojas Gil Andrea Paola ,

Introduction: Thyroxine is important for nervous system development. Subclinical hypothyroidism (SCH), a mild thyroid dysfunction, is associated with impaired cognitive function in children and mood disorders in adults. Serotonin is also involved in brain development, mood and behavior modulation. The possible interaction between thyroid function tests, serum serotonin concentrations and emotional intelligence, was studied.Method...

hrp0086fc4.4 | Pathophysiology of Obesity | ESPE2016

The Role of Apoptotic Marker Apo-1/Fas in the Metabolism and Endothelial Function of Healthy Children

Maganna Maria , Katsa Maria Efthymia , Ioannidis Anastasios , Zyga Sofia , Tsironi Maria , Sachlas Athanasios , Routsi Kleopatra , Dolianiti Loukia , Rojas Gil Andrea Paola

Background: Apoptosis is a programmed sequence of events towards cell death. Blood vessels employ apoptosis for remodeling during development and to maintain homeostasis during adulthood. The atherosclerotic process begins in early childhood and is correlated with obesity and metabolic disorders.Objective and hypotheses: To investigate the correlation of apoptotic marker Apo-1/Fas with children’s biochemical and anthropometric characteristics.<p...

hrp0089fc12.2 | Diabetes and Insulin 2 | ESPE2018

Apoptosis and Oxidative Stress Markers During the Oral Glucose Tolerance Test (OGTT)

Gil Andrea Paola Rojas , Katsa Maria Efthymia , Tzortzis Nomikos , Ioannidis Anastasios , Kostopoulou Eirini , Spiliotis Bessie E

Background: In adults, insulin resistance is associated with vascular damage and progressive loss of the endothelial protective functions. Additionally, it further complicates the micro- and macro- vascular environment through increasing oxidative stress and inflammation.Aim: The purpose of this study was to evaluate how apoptosis and antioxidant markers are correlated with biochemical markers in children, during the glucose tolerance te...

hrp0086p1-p468 | Fat Metabolism and Obesity P1 | ESPE2016

Association of Fasting Triglycerides to High-Density Lipoprotein Ratio with Risk for Metabolic Disorders in Children

Efthymia Katsa Maria , Ioannidis Anastasios , Zyga Sofia , Sachlas Athanasios , Tsironi Maria , Paola Rojas Gil Andrea

Background: Atherosclerosis begins in childhood and progresses silently. Triglycerides/HDL ratio(TG/HDL) is a risk factor for cardiovascular diseases.Objective and hypotheses: To investigate TG/HDL as possible predictive factor for metabolic disorders in children.Method: Descriptive correlation, with 110 children (6–12 years old) in Sparta, Greece. Anthropometric and biochemical analyzes were performed.R...

hrp0084p2-402 | GH &amp; IGF | ESPE2015

The Involvement of the Epidermal Growth Factor Receptor in the Successful GH Signalling and the Role of p21 in the Negative Regulation of the GH/GHR and EGF/EGFR Pathways, in GH Transduction Defect

Kostopoulou Eirini , Gil Andrea Paola Rojas , Karvela Alexia , Spiliotis Bessie Eugenia

Background: GH transduction defect (GHTD) is characterised by severe short stature and impaired STAT3 phosphorylation, which is overcome by simultaneous induction of GHTD fibroblasts with 200 ng/ml GH and short interference mRNA CIS (GH200/siRNA) or with 1 000 ng/ml GH (GH1000) and is clinically expressed with ‘catch-up’ growth after rhGH treatment.Objective and hypotheses: The involvement of epidermal growth factor receptor (EGFR) in the succe...

hrp0084p2-404 | GH &amp; IGF | ESPE2015

The Role of β-TrCP, an E3 Ubiquitin Ligase, in the Signalling of the GH and Epidermal Growth Factor Pathways in Growth Hormone Transduction Defect

Kostopoulou Eirini , Gil Andrea Paola Rojas , Karvela Alexia , Spiliotis Bessie Eugenia

Background: epidermal growth factor (EGF) stimulates cell growth and differentiation through its receptor EGFR. Cross-talking between the GH and EGF signaling pathways is important for normal cellular development. GH transduction defect (GHTD), a clinical disorder characterized by impaired STAT3 phosphorylation due to excessive GHR degradation, is caused by over-expression of the E3 ubiquitin ligase, CIS.Induction of GHTD fibroblasts with 200 ng/ml hGH (GH200) and silencing mR...