hrp0092p1-414 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology (2) | ESPE2019

Gonadal Insufficiency and Affecting Factors in Patients with Bone MarrowTransplantation(BMT) for Non-malignantIndications in Childhood or Adolescence

Er Eren , Aksoylar Serap , Mehdiyeva Humay , Özek Gülcihan , Özen Samim , Göksen Damla , Darcan Sükran

Introduction: Gonadal insufficiency is a common long-term endocrinological complication of BMT and is mainly associated with the chemotherapy protocol. In the literature, gonadal insufficiency after BMT varies between 66% -80% in girls and 35-60% in boysAim: to investigate the frequency and the factors affecting gonadal insufficiency in cases with BMT due to non-malignant indications in children or adolescenc...

hrp0092p2-129 | Fat, Metabolism and Obesity | ESPE2019

Characterization of Adherence to Follow-up and Therapeutical Outcomes in a Large Cohort of 1300 Patients with Obesity Visited in a Specialized Tertiaty Care Center

Martínez-Villanueva Julián , González-Leal Rocío , Argente Jesús , Ángel Martos-Moreno Gabriel

Background: Adherence to follow-up visits in children and adolescents with obesity is a key factor for successful therapeutic outcomes in these patients.Objective: To analyze the adherence to scheduled visits and drop-out rate and the anthropometric, metabolic and behavioral outcomes as a result of an intervention program in a large cohort of children and adolescents with obesity.Patients a...

hrp0092p2-195 | Growth and Syndromes (to include Turner Syndrome) | ESPE2019

The Clinical Features and Effect of Growth Hormone Treatment in 3-M Syndrome Cases with Severe Growth Retardation

Pinar Öztürk Ayse , Altunoglu Umut , Karakiliç Özturan Esin , Toksoy Güven , Poyrazoglu Sükran , Bas Firdevs , Uyguner Oya , Darendeliler Feyza

Background: 3-M syndrome is an autosomal recessive growth disorder characterised by severe prenatal and postnatal growth retardation caused by mutations in CUL7,OBSL1 or CCDC8.Clinical characteristics include dysmorphic facial features and skeletal abnormalities.Aim: Evaluation of clinical and molecular findings and the effect of growth hormone (GH) threrapy in seven patients with 3-M syndrome from five different familie...

hrp0092p2-255 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology | ESPE2019

A Rare Cause of 46, XX ovotesticular DSD: Tetragametic Gonadal Chimerism

Uçar Ahmet , Güran Tülay , Eren Funda , Dokucu Ali Ihsan , Sahin Süleyman , Tanik Canan

Introduction: Virilization and hirsutism are clinical findings of androjen excess in females mostly due to polycystic ovary syndrome, although androgenic drugs, nonclassic congenital adrenal hyperplasia and androgen secreting adrenal/ovarian lesions are also implicated. 46, XX ovotesticular disorder of sex development (DSD) is the rarest form of DSD with an incidence of less than 1 in 20000.Case report: A 15-year-old ado...

hrp0092p3-99 | Fat, Metabolism and Obesity | ESPE2019

"Influence of Eating Habits, Sleep Patterns and Physical Activity on Anthropometric Variables and Body Composition in Children with Obesity"

Gavela-Pérez Teresa , De Dios Olaya , Herrero Leticia , Pérez-Segura Pilar , Garcés Carmen , Soriano-Guillén Leandro

Objectives: The etiopathogenetic of childhood obesity is related to genetic and environmental factors: not only caloric intake or physical activity have an important influence, but also circadian rhythms, including healthy sleep.The objectives of this study were: a) to analyze the different patterns and duration of sleep, eating habits, meal schedules, time dedicated to exercise and screens of obesity children; b) to evaluate its possibl...

hrp0092p3-250 | Thyroid | ESPE2019

Evaluation of Clinical, Demographic Data and Treatment Results of Cases with Graves' Disease

Aldemir Sönmez Alev , Mert Erbaş İbrahim , Paketçi Ahu , Acar Sezer , Demir Korcan , Böber Ece , Abaci Ayhan

Introduction: Graves' disease is the most common cause of hyperthyroidism in children and adolescents, characterized by development of stimulant antibodies against thyrotropin (TSH) receptors. Environmental and genetic factors are thought to be responsible in triggering autoimmunity.Materials and Methods: Twenty-nine cases, with Graves' disease diagnosed in Pediatric Endocrinology clinic between January 1999 and ...

hrp0089s6.1 | Molecular Mechanisms of Tissue Sensitivity to Glucocorticoids: Potential Clinical Implications | ESPE2018

Cardiomyocyte Glucocorticoid and Mineralocorticoid Receptors Antagonistically Regulate Heart Disease

Oakley Robert H , Cruz-Topete Diana , He Bo , Foley Julie F , Myers Page H , Willis Monte S , Gomez-Sanchez Celso E , Chambo Pierre , Cidlowski John A

Stress is increasingly associated with cardiac disease. Glucocorticoids are primary stress hormones that regulate homeostasis through two nuclear receptors, the glucocorticoid receptor (GR) and mineralocorticoid receptor (MR). Cardiomyocytes express both receptors but little is known concerning their specific and coordinated actions in heart physiology and pathology. To examine the in vivo function of glucocorticoid signaling in the heart, we generated mice with cardi...

hrp0089rfc2.1 | Bone, Growth Plate & Mineral Metabolism 1 | ESPE2018

High-Resolution MRI Imaging of Bone-Muscle-Fat in Glucocorticoid Treated Boys with Duchenne Muscular Dystrophy: Results from the ScOT-DMD Study

Joseph Shuko , Dunne Jennifer , Elsharkasi Huda , Foster John , Horrocks Iain , Di Marco Marina , McComb Christine , Ahmed S Faisal , Wong Sze Choong

Background: The pathophysiological mechanism of skeletal fragility in Duchenne Muscular Dystrophy (DMD) is unclear.Objective: To compare trabecular bone microarchitecture, cortical geometry, muscle area and fat fraction (FF) at distal femur and vertebral bone marrow adiposity (BMA) between DMD and controls.Method: Bone-muscle and muscle FF were assessed using 3T MRI and Dixon technique. BMA was assessed using 1H-MRS. Results expres...

hrp0089rfc11.5 | Bone, Growth Plate & Mineral Metabolism 2 | ESPE2018

The Determinants of Skeletal Fragility in Children with Type 1 Diabetes Mellitus

Chen Suet Ching , Shepherd Sheila , McMillan Martin , McNeilly Jane , McComb Christie , Foster John , Robertson Kenneth J , Wong Sze Choong , Ahmed S Faisal

Background: The pathophysiology of the increased fracture risk in Type 1 Diabetes Mellitus (T1DM) remains unclear.Objectives: Perform multimodality assessment to determine the effects of T1DM on bone health and fractures.Methods: Thirty-two children with T1DM at a median (range) age of 13.7 years (10.4, 16.7), and median HbA1c 65mmol/mol (27,100) were recruited. Serum bone alkaline phosphatase (BAP) and c-terminal telopeptide type ...

hrp0089p1-p040 | Diabetes & Insulin P1 | ESPE2018

Poor Metabolic Control in Children and Adolescents with Type 1 Diabetes and Psychiatric Comorbidity

Sildorf Stine M , Breinegaard Nina , Lindkvist Emilie B , Tolstrup Janne S , Boisen Kirsten A , Teilmann Grete K , Skovgaard Anne Mette , Svensson Jannet

Objective: Type 1 diabetes in childhood is associated with an increased risk of psychiatric morbidities. We investigated predictors and diabetes outcomes in a pediatric population with psychiatric comorbidities.Research Design and Methods: Nationwide pediatric registerbased study. Data from the Danish national childhood diabetes register (DanDiabKids) and The National Patient Register were collected (1996–2015) for this population-based study. We us...