hrp0082p1-d1-60 | Diabetes | ESPE2014

Activity of Neutral Alfa-Glucosidase in the Urine of Children and Adolescents with Type 1 Diabetes Mellitus and Diabetic Nephropathy

Sadykova Akidahon , Rakhimova Gulnara

Aim: To identify clinical significance of enzymuria in early diagnosis of DN in children and adolescents with type 1 diabetes mellitus.Materials and methods: We examined 112 patients (47males/55 females) with type 1 diabetes mellitus. By the DN severity the patients were divided into following groups: with normoalbuminuria (NAU) (n=47), with microalbuminuria (MAU) (n=44) and with marked proteinuria (MP) (n=19). Ten healthy subj...

hrp0082p2-d1-328 | Diabetes | ESPE2014

Functional Condition of the Kidneys (K/DOQI, 2002) By ACE Gene I/D Polymorphism in Children and Adolescents with Type I Diabetes Mellitus

Sadykova Akidahon , Rakhimova Gulnara

Objective and hypotheses: The work was initiated to assess functional condition of the kidneys and to study interrelation between ACE gene I/D polymorphism and stage of chronic kidney disease in children and adolescents with type 1 diabetes mellitus (DM) in compliance with K/DOQI recommendations (2002).Method: We examined 120 children and adolescents with type 1 DM, 53 (44.2%) males and 67 (55.8%) females among them (mean age 13.8±0.24 years. GFR wa...

hrp0092p2-89 | Diabetes and Insulin | ESPE2019

The Prevalence of Chronic Kidney Disease in Children and Adolescents with Type 1 Diabetes Mellitus in The Republic of Uzbekistan

Rakhimova Gulnara , Sadikova Akidahon

Chronic kidney disease (CKD) is one of the most significant medical and socio-economic problems of our time.Purpose of the Research: To study the prevalence of chronic kidney disease in children and adolescents with type 1 diabetes in Uzbekistan.Materials and Methods: For conducting epidemiological studies there were examined children and adolescents of type 1 diabetes. Epidemiological data were st...

hrp0086p1-p207 | Diabetes P1 | ESPE2016

Interrelation between ACE Gene I/D Polymorphism and Chronic Kidney Disease Severity in Uzbek Children and Adolescents with Type 1 Diabetes Mellitus

Rakhimova Gulnara , Sadykova Akida

Background: Generally, diabetic nephropathy onsets and progresses within 5–10 years after DM onset resulting in chronic kidney disease (CKD) causing death in every 4–5th patient with type I DM. Molecular-genetic studies of endogenous/genetic CKD risk factors are of high relevance in understanding of pathogenetic mechanisms underlying formation of nephrosclerosis, and in improvement of interventions.Objective and hypotheses: To assess renal func...

hrp0084p3-738 | Diabetes | ESPE2015

Prestarium Pharmacogenetic Efficacy in Predicting Diabetic Nephropathy in Children and Adolescents

Rakhimova Gulnara , Sadikova Akida

Aim: The work was initiated to study efficacy of prestarium in normoalbuminuric patients with type 1 diabetes mellitus by ACE genotype upon primary diabetic nephropathy (DN) prevention.Materials and methods: We examined normoalbuminuric 22 patients with type 1 diabetes mellitus aged from 12 to 17 years with DN duration ≧ 10 years divided into two groups by ACE polymorphism, that is, the one with II genotype (n=11) and the one with DD geno...

hrp0084p2-288 | Diabetes | ESPE2015

Functional Condition of the Kidneys (K/DOQI, 2002) by ACE Gene I/D Polymorphism in Children and Adolescents with Type 1 Diabetes Mellitus

Rakhimova Gulnara , Sadikova Akida , Alimova Nasiba

Aim: The work was initiated to assess functional condition of the kidneys and to study interrelation between ACE gene I/D polymorphism and stage of chronic kidney disease in children and adolescents with type 1 diabetes mellitus (DM) in compliance with K/DOQI recommendations (2002).Materials and methods: We examined 120 children and adolescents with type 1 DM, 53 (44.2%) males and 67 (55.8%) females among them (mean age 13.8±0.24 years; 95% CI: 13.3...