hrp0084p2-505 | Perinatal | ESPE2015

Evaluation of Thyroid Function in Preterm Newborns of 24–30 Weeks of Gestation

Ariadna Campos-Martorell , Maria Clemente , Diego Yeste , Felix Castillo , Maria Narvaez Karla , Antonio Carrascosa

Background: Preterm newborns due to their immaturity, a higher incidence of mortality and increased susceptibility to iodine, are at risk of decreased thyroid function. Low levels of thyroid hormones during a critical period for the development of the central nervous system may negatively affect their psychomotor development. Screening for congenital hypothyroidism with capillary TSH is invalid for preterm babies and would require an specific thyroid function control.<p cl...

hrp0084p3-594 | Adrenals | ESPE2015

X-Linked Adrenoleucodystrophy Presenting as Addison’s Disease in Childhood: A Case Report

Meloni Antonella , Congia Mauro , Casini Maria Rosaria , Ibba Silvia , Bonomi Marco , Rosatelli Maria Cristina

Background: X-Linked Adrenoleucodystrophy (X-ALD) is a rare neurodegenerative disorder characterised by impaired peroxisomal beta-oxidation of very long chain fatty acids (VLCFA; ≧C22) which is reduced to about 30% of control levels. Consequently, there is an accumulation of VLCFA in plasma and tissues, including the white matter of the brain, the spinal cord and adrenal cortex. It is caused by mutation in the ABCD1 gene encoding a peroxisomal transmembrane protein (ALD...

hrp0084p3-860 | Fat | ESPE2015

Metabolic Syndrome in Greek Adolescents and the Effect of 6-Month Educational/Behavioural School Interventions

Bacopoulou Flora , Efthymiou Vassiliki , Papaefthymiou Maria , Landis Georgios , Palaiologos George , Kaklea Maria , Papassotiriou Ioannis , Chrousos George

Background: Data regarding the prevalence of metabolic syndrome (MS) in Greek adolescents and the effect of school interventions are scarce.Objective and hypotheses: To study the prevalence of MS in a representative sample of Greek adolescents and evaluate the impact of a 6-month educational-behavioral intervention.Method: Cross-sectional anthropometric data ((height, weight, waist circumference (WC)), blood pressure (BP), fasting ...

hrp0084p3-947 | GH &amp; IGF | ESPE2015

Medical and Biochemical Effects of Intervention Program in Patients with Poor Adherence to rhGH Treatment

Martinez Maria , Murillo Marta , Guerrini Estefania , Granada Maria Luisa , Bel Joan

Background: Optimising adherence to treatment in paediatric patients is important, since non-adherence may lead to incorrect interpretation of growth results and in the treatment course. It has been found that injection frequency is correlated with growth response and final height among children treated with rhGH.Objective and hypotheses: The main aim of this study was to evaluate IGF1 levels and growth velocity before and after a medical intervention in...

hrp0094p2-205 | Fat, metabolism and obesity | ESPE2021

Assessment of cardiometabolic risk factor clustering in obese children and adolescents with metabolic syndrome

Tragomalou Athanasia , Manou Maria , Loukopoulou Sofia , Binou Maria , Papadopoulou Marina , Kassari Penio , Charmandari Evangelia ,

Background: Obesity in childhood and adolescence has reached epidemic proportions. Endothelial dysfunction, as a consequence of dyslipidemia, hypertension, insulin resistance and inflammation, imposes a substantial risk for the development of metabolic syndrome (MS) in childhood and compromises the health of the pediatric population by promoting premature development of atherosclerotic cardiovascular disease.Aim: To inve...

hrp0094p2-206 | Fat, metabolism and obesity | ESPE2021

HOMA-IR in obese children with BMI ≥2.5SDS, but not <2.5SDS, differ significantly from normal weight children

Leka-Emiri Sofia , Dikou Maria , Evangelopoulou Catherine , Kafetzi Maria , Petrou Vasilios , Vlachopapadopoulou Elpis , Michalacos Stefanos ,

Objective: Compare HOMA-IR between obese and normal weight children.Methods: 292 children (156 females), BMI (≥0SD), Tanner stage 1/>2: 163/129, divided in four groups (Group 1: 0SD<BMI<2SD, Group 2: 2SD≤BMI<2.25SD, Group 3: 2.25SD≤BMI<2.5SD, Group 4: BMI≥2.5SD) were analyzed retrospectively from the medical records. Age, sex, fasting blood glucose and insulin as well as the ho...

hrp0094p2-223 | Fat, metabolism and obesity | ESPE2021

Absence of dyslipidemia in obese children with BMI ≥2.5SDS and similar lipidemic profile to those with BMI <2.5SDS or normal weight

Leka-Emiri Sofia , Dikou Maria , Evangelopoulou Catherine , Kafetzi Maria , Petrou Vasilios , Vlachopapadopoulou Elpis , Michalacos Stefanos ,

Objective: Compare triglycerides, total cholesterol, HDL and LDL levels between obese and normal weight children.Methods: 547 children (286 females) with BMI (≥0SD) were divided in four groups (Group 1: 0SD<BMI<2SD, Group 2: 2SD≤BMI<2.25SD, Group 3: 2.25SD≤BMI<2.5SD, Group 4: BMI≥2.5SD) and analyzed retrospectively from the medical records. Age, sex, BMI z-score, triglycerides, tot...

hrp0094p2-365 | Pituitary, neuroendocrinology and puberty | ESPE2021

Gonadotropin Flare with Different Depot GnRH Agonists: Comparative Analysis.

Freire Analia , Arcari Andrea , Gabriela Ballerini Maria , Ignacio Bergada , Gabriela Ropelato Maria , Gryngarten Mirta ,

Central precocious puberty (CPP) is effectively treated by inhibition of GnRH signaling through GnRH receptor desensitization with depot GnRH agonists (dGnRHa), but the first injection is associated with a surge in LH and FSH (flare) that proportionally increases estradiol levels. When estradiol levels drop, usually within a fortnight, vaginal bleeding may be seen in a small number of girls. Although dGnRHa that use higher, longer-acting doses are increasingly being used in gi...

hrp0095p1-366 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

Hemorrhagic pituitary apoplexy due to pituitary adenoma: description of two cases in two adolescent males

Ciccone Sara , Vestrucci Benedetta , Lia Cataldi Maria , Balestrieri Antonio , Ruggiero Maria , Grandone Anna

Context: Pituitary apoplexy is rare endocrine emergency, resulting from ischemia and/or hemorrhage and necrosis of a pituitary tumor (typically an adenoma). Children and adolescents show severe headache sometimes associated with cranial neuropathies from compression of the optic chiasm or the cavernous sinus.Case presentation: A 15-year-old boy was admitted with severe headache and vomiting since 3 days, without visual d...

hrp0095p2-274 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2022

Congenital hypogonadotropic hypogonadism caused by a novel mutation of GnRHR gene: a case report

Cristina Maggio Maria , Venezia Renato , Maria Di Blasio Anna , Corsello Giovanni

Hypogonadotropic hypogonadism is characterized by low levels of gonadotropins and delayed or absent sexual development. Most of the patients reach the diagnosis in late adolescence or in adulthood. A timely, appropriate diagnosis implicates a better clinical outcome and treatment timing. We describe the clinical case of a 15-year-old girl with primary amenorrhea. Stature and weight were in accordance with mid parental height; Tanner stage: PH2 B1. FSH, LH, oestradiol showed pr...