hrp0092p1-408 | Pituitary, Neuroendocrinology and Puberty (2) | ESPE2019

Training in Pubertal Assessment – First Step to the Observational Pilot Study PROSPEL (Premier Observatoire des Stades Pubertaires en Libéral)

Jesuran-Perelroizen Monique , Puel Olivier , Mazzarino Johan

Introduction: Recent publications report an earlier age of onset of pubertal changes in the US and Europe. Referrals to pediatric-endocrinologist for early puberty are increasing. Precocious puberty diagnosis is often delayed, especially in boys. Improvement in pubertal assessment (age at onset of puberty) by pediatricians and general practitioners is needed to participate in the PROSPEL study and to improve management of pubertal abnormalities.<p class="a...

hrp0092p1-132 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology | ESPE2019

What is the Recurrence Rate of Benign Ovarian Tumors in Childhood? Ovarian Benign Organic Tumors (OBT) are a Rare Pathology in Childhood that Require Conservative Surgery with an Unknown Risk of Recurrence

Detho Nina , Cartault Audrey , Abbo olivier , Mouttalib sofia , Pienkowski Catherine

Aim: The aim of the study was to predict the risk of tumor recurrence in OBTMaterial and Methods: We conducted a retrospective, observational study (2001-2018) on the management of OBT in girls aged 0 to 18 at Toulouse University Hospital, France.Results: 68 patients were included. 16% were prepubertal. Mean age was 11.35 ± 3.08 years. Pain was the main symptom in 49% ...

hrp0089p2-p221 | GH &amp; IGFs P2 | ESPE2018

Growth Hormone Treatment in Children Born Small for Gestational Age (SGA)

Janchevska Aleksandra , Krstevska-Konstantinova Marina , Jordanova Olivera , Tasevska-Rmush Liljana , Tasic Velibor , Gucev Zoran

Introduction: Growth failure is a common consequence in small for gestational age (SGA) children.Patients and methods: The growth patterns and serum insulin like growth factor 1 (IGF1) concentrations before and after the 1st year under GH treatment of 32 short stature SGA born children have been evaluated. In addition, we investigated the insulin like growth factor 1 receptor (IGF1R) exon 2 as a hotspot for IGF1R genetic alterations. It is of note that n...

hrp0095p2-227 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

Growth Hormone Deficiency in A Boy with Duplication 5q35.2q35.3

Janchevska Aleksandra , Plasheska-Karanfilska Dijana , Jordanova Olivera , Beqiri-Jashari Ardiana , Tasic Velibor , Gucev Zoran

Introduction: The genomic disorders caused by rearrangements in region 5q35, including the NSD1 (nuclear receptor SET domain containing protein-1) gene have various phenotypes depending on presence of deletions, duplications or inversions. Patients carrying microduplication have microcephaly, short stature, and mild to moderate intellectual delay or learning disability.Patients and methods: A six-year-old boy wa...

hrp0086p1-p563 | Perinatal Endocrinology P1 | ESPE2016

Hyponatremia in Infants Under 100 Days Old: Frequently Overlooked and Multifactorial

Storey Caroline , Dauger Stephane , Baud Olivier , Deschenes Georges , Carel Jean-Claude , Martinerie Laetitia

Background: Hyponatremia is one of the most common electrolyte disorders in hospitalized children and early diagnosis and management are crucial to prevent morbidity and mortality. Because of the physiological resistance to aldosterone under 3 months of age, the mechanisms leading to hyponatremia are often misunderstood.Objective and hypotheses: To assess the prevalence of hyponatremia in hospitalized infants younger than 100 days and evaluate the mechan...

hrp0086p1-p749 | Pituitary and Neuroendocrinology P1 | ESPE2016

Age of Onset of Puberty in Yaounde, Which Normative Reference Data?

Sap Suzanne , Komba Darelle , Sobngwi Eugene , Obama Marie Therese , Koki Paul Olivier , Mbanya Jean Claude

Background: The age of onset of puberty varies from country to another and, within every country, from one socioeconomic group to another. In Sub-Saharan Africa, particularly in Cameroon, there is paucity of data on this topic.Objective and hypotheses: To determine clinically meaningful normative reference data that describe the timing of sexual maturity indicators among Cameroonian children and to determine factors that influence the onset of this matur...

hrp0084p3-832 | Fat | ESPE2015

The French Experience in Bariatric Surgery ‘Laparoscopic Adjustable Gastric Banding’ in Adolescence

Dabbas Myriam , Khen-Dunlop Naziha , De Filippo Jean Paul , Bougneres Pierre , Goulet Olivier , Revillon Yann

Background: Because the success rate of lifestyle interventions is modest in severely obese adolescents, surgical treatments are now proposed. Laparoscopic adjustable gastric banding (LAGB) represents an attractive treatment with minimal morbidity and reversible procedure.Method: All adolescents were included in prospective longitudinal assessment and entirely managed by a pediatric team. Surgery was proposed only after at least 1-year lifestyle interven...

hrp0086p2-p81 | Adrenal P2 | ESPE2016

Assessment of Cardiac Function in Children Followed up for Congenital Adrenal Hyperplasia: A Case Control Study in Cameroon

Tony Nengom Jocelyn , Sap Ngo Um Suzanne , Chelo David , Carole Mbono Betoko Ritha , Olivier Koki Ndombo Paul

Background: Diagnosis of congenital adrenal hyperplasia (CAH) is delayed in developing countries and children are long exposed to high levels of androgens. These androgens have deleterious effect on heart.Objective and hypotheses: Evaluate cardiac function of children followed for CAH and compared it to a group of healthy children.Method: We carried out a case-control study, 1 case for 2 controls matched for age and genotypic sex, ...

hrp0084p1-124 | Thyroid | ESPE2015

Thyrocytes are Particularly well Protected Against Oxidative Stress Induced by H2O2

Ghaddhab Chiraz , Van Den Eeckhaute Emmanuel , Hancisse Olivier , Driessens Natacha , Dumont Jacques-Emile , Miot Francoise , Corvilain Bernard

Background: H2O2 produced in large quantities in the thyroid may play a role in the pathogenesis of thyroid nodules and cancer. In vitro, moderate amounts of H2O2 are able to cause similar DNA damage compared to irradiation and even to induce RET/PTC rearrangements.Objective and hypotheses: We compared the defence mechanisms against H2O2 and irradiation in human thyrocytes, T-cell...

hrp0084p1-125 | Thyroid | ESPE2015

Thyrocyte is Particularly Well Protected Against Oxidative Stress Induced by H2O2

Ghaddhab Chiraz , Van Den Eeckhaute Emmanuel , Hancisse Olivier , Driessens Natacha , Versteyhe Soetkin , Miot Francoise , Dumont Jacques-Emile , Corvilain Bernard

Background: H2O2 produced in large quantities in the thyroid may play a role in the pathogenesis of thyroid nodules and cancer. In vitro, moderate amounts of H2O2 are able to cause similar DNA damage compared to irradiation and even to induce RET/PTC rearrangements.Objective and hypotheses: We compared the defence mechanisms against H2O2 and irradiation in human thyrocytes, T-cell...