hrp0086fc13.1 | Management of Obesity | ESPE2016

Quantitative Proteomic of Rat Livers Shows a Major Reprogramming of Mitochondrial Enzymes in Food-Restriction and Increased Stress Hallmarks in Ad Libitum Feeding

Gat-Yablonski Galia , Finka Andrija , Pinto Galit , Quadroni Manfredo , Shtaif Biana , Goloubinoff Pierre

Background: Studies in young mammals on the qualitative and quantitative molecular effects of food restriction (RES) and re-feeding, leading to catch up growth (CU) are scarce. Whereas RES may lead to growth and developmental deficits in children, it is a proven treatment to prolong life in all animals checked.Objective and hypotheses: We used MS analysis to understand how RES might lead to growth attenuation and prolonged life span and identify the majo...

hrp0082p1-d1-135 | Growth | ESPE2014

The Association Between Adipocytes and Growth is Mediated by Growth and Differentiation Factor 5

Shtaif Biana , Dror Nitzan , Bar-Maisels Meytal , Phillip Moshe , Gat-Yablonski Galia

Background: The association between nutrition and growth is common knowledge but the mechanism is still unelucidated. Several reported cases in the literature describe growth without GH, that in most cases were associated with obesity, suggesting, that the adipocytes might have a role in regulating linear growth.Objective and hypotheses: The aim of the study was to search for a skeletal growth factor that is secreted by adipocytes....

hrp0084p3-1026 | Growth | ESPE2015

Fasting and Post-Meal Levels of Appetite Regulating Hormones, before and Following GH Treatment, in Children with Idiopathic Short Stature

Yackobovitch-Gavan Michal , Gat-Yablonski Galia , Shtaif Biana , Phillip Moshe , Lazar Liora

Background: Poor appetite is common in children with idiopathic short stature (ISS), and is usually improved with GH therapy.Objective and hypotheses: To investigate the effect of GH therapy on appetite regulating hormones following a standard meal test (SMT) and to examine the association between these changes and growth response, body composition and resting energy expenditure (REE).Method: Nine ISS pre-pubertal children underwen...

hrp0094p2-80 | Bone, growth plate and mineral metabolism | ESPE2021

Effect of Soy and Whey on growth pattern in young male Sprague-Dawley rats

Bar-Maisels Meytal , Menahem Chen , Shtaif Biana , Gabet Yankel , Bab Sahar , Phillip Moshe , Gat-Yablonski Galia ,

Background and Aims: The most effective environmental factor that affect longitudinal growth is nutrition, but the exact composition and the relative benefits of specific dietary proteins in supporting linear growth is unknown. In the current study, we compared the effect of whey and soy proteins on linear growth and bone strength in young fast growing male rats. Both proteins contain all essential amino acids and are considered the best proteins in their cate...

hrp0094p1-59 | Bone B | ESPE2021

Cartilage -specific knockout of SIRT1 significantly reduces bone quality and catch-up growth efficiency

Shtaif Biana , Bar-Maisels Meytal , Gabet Yankel , Hiram-Bab Sahar , Yackobovitch-Gavan Michal , Phillip Moshe , Gat-Yablonski Galia ,

Background: Spontaneous catch-up (CU) growth occurs when a growth-restricting factor is resolved. However, its efficiency is sometimes inadequate and growth deficits remain permanent. The therapeutic toolbox for short stature is currently very limited. Our previous studies using a nutrition-induced CU growth model showed that the level of sirtuin-1 (SIRT1) was significantly increased in food-restricted animals and decreased during CU growth.<p class="abste...