hrp0082fc4.2 | Growth | ESPE2014
De Leonibus Chiara
, Barinaga-Rementeria Ramirez Irene
, Hurlstone Adam
, Clayton Peter
, Stevens Adam
Background: GRB10 negatively regulates IGF1 signalling, influences growth and promoter polymorphisms are associated with GH response1. GRB10 knockout-mouse models display foetal overgrowth2, however, the mouse model has only partial similarity to human growth3. There is evidence that the zebrafish is an appropriate model to study growth4 and has the advantage of being easily genetically manipulated.<p class="abs...