hrp0084p2-172 | Adrenals | ESPE2015

Resveratrol Disrupts Steroidogenesis in Human Foetal Adrenals

Savchuk Iuliia , Soder Olle , Svechnikov Konstantin

Background: The phytoestrogen resveratrol found in grapes and other plants has attracted considerable interest due to its proposed ability to extend lifespan, attenuate the development of metabolic syndrome in obese subjects and protect against cardiovascular disease. Among other functions resveratrol has been reported to affect the endocrine system. Self-medication with high pharmacological doses of this polyphenol with the aim to improve metabolic parameters and health canno...

hrp0086rfc4.2 | Pathophysiology of Obesity | ESPE2016

Adipocytokines Delay Pubertal Maturation of Human Sertoli Cells

Wagner Isabel V. , Yango Pamela , Svechnikov Konstantin , Tran Nan D. , Soder Olle

Background: Obesity and metabolic syndrome related co-morbidities are increasingly recognized in children. Reproduction is an important target of obesity complications, including adverse effects on spermatogenesis and steroidogenesis in males. Adipocytokines are key players in various complications of obesity.Objective and hypotheses: The aim was to study the potential effects of adipocytokines on Sertoli cell function and possibly link the findings to t...

hrp0086rfc4.6 | Pathophysiology of Obesity | ESPE2016

Adipose Tissue – A Source of Hyperandrogenism in Obese Females?

Wagner Isabel V. , Sahlin Lena , Savchuk Iuliia , Svechnikov Konstantin , Soder Olle

Background: Obesity in females is often associated with metabolic complications and hyperandrogenism. However, the source of androgens is not entirely clear.Objectives and hypotheses: Our objective was to find out if adipose tissue (AT) is a site of steroid production during childhood and adolescence, and if this source could add to hyperandrogenism in obese females.Methods: Parametrial and inguinal adipose tissue was collected and...

hrp0084p2-334 | Fat | ESPE2015

Childhood Obesity Negatively Influences Adult Leydig Cell Function

Wagner Isabel V , Kloting Nora , Kiess Wieland , Soder Olle , Svechnikov Konstantin

Background: Childhood obesity is a global health problem and co-morbidities develop already during childhood and adolescence. Male obesity impacts negatively on reproductive function. Testosterone is decreased, sperm quality reduced, and the physical and molecular structure of germ cells altered in obese males. However, less is known about the role of prepubertal obesity on future reproductive function. We therefore explored Leydig cell function and reproductive potential in a...

hrp0089p2-p363 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology P2 | ESPE2018

The Human Genital Tubercle is Steroidogenic Organ at Earlypregnancy

Savchuk Iuliia , Morvan Marie-Line , Philippe Antignac Jean , Gemzell-Danielsson Kristina , Le Bizec Bruno , Soder Olle , Svechnikov Konstantin

It is generally accepted that androgens produced by fetal Leydig cells (FLC) control proper masculinization of the male external genitalia. Here, we hypothesized that the human genital tubercle (GT) has potential to synthesize androgens independently of FLC at early pregnancy. We observed that human GT of both genders have capacity to synthesize steroids of the Δ4, Δ5 and alternative pathway of DHT synthesis including the androgen itself. The presence of steroids in ...

hrp0084p2-382 | Fat | ESPE2015

Insulin-Like Factor 5 –A Novel Orexigenic Hormone in Humans is Dysregulated in Obesity

Wagner Isabel V , Flehmig Gesine , Scheuermann Kathrin , Loffler Dennis , Korner Antje , Kiess Wieland , Stumvoll Michael , Dietrich Arne , Blueher Matthias , Kloting Nora , Soder Olle , Svechnikov Konstantin

Background: Insulin-like factor 5 (INSL5), a member of the insulin superfamily, is expressed in the colorectum and hypothalamus. INSL5 levels are elevated by prolonged calorie restriction and declined with feeding, suggesting that it might be an orexigenic hormone.Objectives and hypotheses: Our aim was to explore the relationship between INSL5 and different metabolic parameters in lean and obese subjects and to identify possible links between INSL5 and t...

hrp0086fc1.3 | Adrenals | ESPE2016

Steroidogenesis in the Human Fetal Adrenals at the End of the First Trimester

Savchuk Iuliia , Morvan M.L. , Soeborg T. , Antignac J.P. , Danielsson K. Gemzell , Bizec B. Le , Soder O. , Svechnikov K.

Background: Steroid hormones produced by the human fetal adrenals (HFA) are suggested to regulate intrauterine homeostasis and the maturation of certain fetal organs necessary for extrauterine life. Appropriate development and hormonal function of the HFA therefore are critical for normal fetal maturation and survival. Little is known about the possible relationship between the expression of steroidogenic enzymes and corresponding transcription factors in the HFA in vivo</...

hrp0092p1-328 | Diabetes and Insulin (2) | ESPE2019

Creating a Neural Network Model Based on Glycemic Variability Indices to Predict the Degree of Compensation for Type 1 Diabetes

Koshmeleva Marina , Samoilova Juliya , Kobyakova Olga , Oleynik Oxana , Brazovskii Konstantin , Nazarenko Valeriya , Filippova Tatiyana , Podchinenova Dariya

Actuality: Standard methods for determining the compensation of the disease don't always reliably reflect the level of the glycemic control of the patient, which leads to decompensation diabetes and reduce the quality and duration of life for patients. Evaluation of glycemic variability indices allows the physicians to predict the risk of developing life-threatening conditions and compensate the diabetesAim: To condu...

hrp0092fc7.1 | Diabetes and Insulin Session 2 | ESPE2019

Deployment of a Predictive Model Based on CpG Methylation Haplotypes Analysis on the Insulin Gene Promoter, in a Cohort of Children and Adolescents with Type 1 Diabetes

Kotanidou Eleni P , Mouzaki Konstantina , Chouvarda Ioanna , Koutsiana Elisavet , Kosvyra Alexandra , Giza Styliani , Galli-Tsinopoulou Assimina

Background: Cytosine-guanine(CpGs) sites in molecules identified as methylated or unmethylated; the combination of them in the genetic sequence of an individual includes a methylation haplotype (methyl-haplotype) for a specific locus. The insulin gene promoter(IGP) is highly regulated by methylation mechanisms, which lead to alteration of gene expression.Aim: To identify IGPmethyl-haplotypes among children/adolescents wi...

hrp0089p1-p074 | Diabetes &amp; Insulin P1 | ESPE2018

Catheter Site Selection and Anthropometric Measurements at Subjects with Type 1 Diabetes and Continuous Subcutaneous Insulin Infusion

Xatzipsalti Maria , Vakaki Marina , Mentesidou Lida , Kourti Afroditi , Patouni Konstantina , Choundala Anna , Stamogiannou Lela , Vazeou Andriani

Introduction: The selection of the insulin catheter length for pump T1D users is based mainly on age and though different sites for insertion have been suggested, it is not clear what the ideal site is according to each person’s body type and subcutaneous fat.Aid: Aid of the study is to identify the proper sites for insulin catheter insertion according to subcutaneous fat and anthropometric characteristics.Methods: Study group...