hrp0092p1-99 | Pituitary, Neuroendocrinology and Puberty | ESPE2019

Eating Behavior and Oxytocin in Childhood-onset Craniopharyngioma Patients: An Exploratory Study

Daubenbüchel Anna M. , Özyurt Jale , Warmuth-Metz Monika , Eveslage Maria , Müller Hermann L.

Background: Childhood-onset craniopharyngioma patients (CP) often suffer from tumor or treatment-related hypothalamic lesions (HL). These lesions may alter production of oxytocin, which plays a major role in the regulation of eating behavior and body composition.Objective: In CP with different degrees HL, we investigated associations between HL, eating behavior/eating attitudes, and oxytocin saliva concentrations (OSC).<...

hrp0086p1-p475 | Fat Metabolism and Obesity P1 | ESPE2016

Reduction of Body Mass and Change in Body Composition of the Participants of the PoZdro! – Programme for Prevention of Diabetes and Civilisation Diseases by Medicover Foundation – Preliminary Results, after the First Year of Interventions

Magnuszewska Hanna , Anyszek Tomasz , Brzezinski Michal , Lech Monika , Soszynski Piotr , Walewski Jacek , Szarejko Kamila , Radziwill Marcin , Mysliwiec Malgorzata , Czupryniak Leszek

Background: Lifestyle interventions are basic tool to treat obesity in the youth. They prevent from civilisation diseases. Globally, there are many programmes including regular meetings with dieticians, exercise specialists, and others. Results are promising, although there’s no consensus regarding one model of recommended diet, exercise’s intensity and frequency of interventions.Objective and hypotheses: Assessment of preliminary results of &#...

hrp0086p2-p765 | Pituitary and Neuroendocrinology P2 | ESPE2016

Symptomatic Rathke Cleft Cyst in Pediatric Patients – Clinical Presentations, Surgical Treatment and Postoperative Outcomes – An Analysis of 38 Cases

Prokop Monika , Moszczyńska Elżbieta , Bogusz Agnieszka , Daszkiewicz Paweł , Szalecki Mieczysław , Roszkowski Marcin

Background: Rathke cleft cysts are benign, epithelium-lined intrasellar and/or suprasellar cysts believed to originate from remnants of the Rathke pouch. Although its prevalence in adults is rather high, Rathke cleft cysts are rare in children. Often they are asymptomatic findings, however depending on their size and localization they can present with a wide spectrum of symptoms.Objective and hypotheses: The aim of the study was to analyse the symptoms a...

hrp0082p1-d3-195 | Pituitary | ESPE2014

Childhood Craniopharyngioma: Changes of Treatment Strategies in Multinational Trials During the Last 12 Years

Hoffmann Anika , Warmuth-Metz Monika , Gebhardt Ursel , Pietsch Torsten , Pohl Fabian , Kortmann Rolf-Dieter , Calaminus Gabriele , Muller Hermann L

Background: Despite high survival rates in childhood craniopharyngioma, prognosis is frequently impaired due to sequelae. Radical surgery was the treatment of choice for several decades. However, even at experienced surgical facilities radical surgery can result in hypothalamic disorders such as severe obesity.Objective and hypotheses: We analyzed, whether treatment strategies for childhood craniopharyngioma patients recruited in German studies (KRANIOPH...

hrp0084p2-509 | Pituitary | ESPE2015

Survival, Hypothalamic Obesity, and Neuropsychological/Psychosocial Status after Childhood-Onset Craniopharyngioma: Newly Reported Long-Term Outcomes

Sterkenburg Anthe S , Hoffmann Anika , Gebhardt Ursel , Warmuth-Metz Monika , Daubenbuchel Anna M M , Muller Hermann L

Background: Quality of life and long-term prognosis are frequently, often severely impaired in craniopharyngioma (CP) patients.Objective and hypotheses: Knowledge of risk factors for long-term outcome is important for optimisation of treatment.Method: Overall survival (OS) and progression-free survival (PFS), BMI, neuropsychological status (EORTCQLQ-C30, MFI-20), and psychosocial status were analysed in 261 patients with childhood-...

hrp0084p2-514 | Pituitary | ESPE2015

Hydrocephalus and Hypothalamic Involvement in Paediatric Patients with Craniopharyngioma or Cysts of Rathke’s Pouch: Impact on Long-term Prognosis

Daubenbuchel Anna M M , Hoffmann Anika , Gebhardt Ursel , Warmuth-Metz Monika , Sterkenburg Anthe S , Muller Hermann L

Background: Paediatric patients with sellar masses such as craniopharyngioma (CP) or cyst of Rathke’s pouch (CRP) frequently suffer disease- and treatment-related sequelae.Objective and hypotheses: We analysed the impact and prognostic relevance of initial hydrocephalus (HY) and hypothalamic involvement (HI) on long-term survival and functional capacity (FC) in children with CP or CRP.Method: Using retrospective analysis of pa...

hrp0095p1-344 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

Puberty patterns in boys with X-linked congenital adrenal hypoplasia.

Kolesinska Zofia , Rojek Aleksandra , Malecka Elzbieta , Slomko-Jozwiak Malgorzata , Obara-Moszynska Monika , Banaszak-Ziemska Magdalena , Niedziela Marek

Background: X-linked congenital adrenal hypoplasia (adrenal hypoplasia congenita, AHC) is a rare life-threating disorder due to pathogenic variants in the NR0B1 gene. It encodes DAX-1, an orphan nuclear hormone receptor, that acts as a transcription factor and is expressed in the adrenals and hypothalamus-pituitary-gonadal (HPG) axis. Therefore, apart from primary adrenal insufficiency, patients present incomplete or absent puberty and infertility due...

hrp0092p1-398 | Pituitary, Neuroendocrinology and Puberty (2) | ESPE2019

Postoperative Quality of Life in Children and Adolescents with Craniopharyngioma – Results of the Prospective Multicenter Trial KRANIOPHARYNGEOM 2007

Eveslage Maria , Calaminus Gabriele , Warmuth-Metz Monika , Kortmann Rolf-Dieter , Pohl Fabian , Timmermann Beate , Schuhmann Martin , Flitsch Jörg , Faldum Andreas , Müller Hermann L.

Background: Craniopharyngioma is an embryonic tumor of low-grade malignancy. Children and adolescents with this diagnosis are analyzed concerning quality of life (QoL) and (progression-free) survival within the project KRANIOPHARYNGEOM 2007.Methods: The prospective, multi-center project consists of a randomized, unblinded substudy with adaptive design and an observational study. The randomized substudy for incompletely r...

hrp0086p2-p855 | Syndromes: Mechanisms and Management P2 | ESPE2016

The Usefulness of Magnetic Resonance Imaging of the Heart and Aorta in the Diagnostic Work-up in Girls with Turner Syndrome

Obara-Moszynska Monika , Rozmiarek Szymon , Lanocha Magdalena , Kociemba Anna , Rabska-Pietrzak Barbara , Janus Magdalena , Siniawski Andrzej , Mrozinski Bartlomiej , Niedziela Marek , Pyda Malgorzata

Background: Congenital heart defects are found in 50% of girls with Turner syndrome (TS). The evaluation of cardiovascular system is an important element in the diagnostic work-up of TS and is of particular significance of cardiologic monitoring, safety aspects of rGH treatment and any pregnancy planning.Objective and hypotheses: Assess the cardiovascular system in TS girls with magnetic resonance imaging of the heart and aorta (CMR and angioMR).<p c...

hrp0084p3-1070 | Hypo | ESPE2015

Severe Neonatal Hypoglycemia in the Newborn Despite Prenatal Diagnosed Cerebral Midline Malformations: a Review of Three Cases

Reschke Felix , Gemulla Gita , Flury Monika , Brenner Sebastian , Schuetzle Heike , Gurth Heidrun , Hahn Gabriele , Taut Heike , Glajzer Jack , Gottschalk Hans-Christian , Hubner Angela

Background: Brain abnormalities like cerebral midline malformations (CMM) can be detected by fetal sonography. CMM with neonatal hypopituitarism may cause severe hypoglycemia.Case presentation: We report about three cases of term eutrophic newborns, which all presented with severe neonatal hypoglycemia despite prenatally diagnosed CMM. All three patients were born vaginally and were immediately breastfed after normal postnatal adaptation. In the first ca...