hrp0082p1-d2-219 | Reproduction (1) | ESPE2014
, Hye Kim Ja
, Hyang Cho Ja
, Choi Jin-Ho
, Yoo Han-Wook
Background: Central precocious puberty (CPP) is mostly idiopathic, however, familial cases of CPP and evidence of genetic factors on pubertal timing by genome-wide association studies suggested genetic causes of CPP.Objective and hypotheses: Molecular defects in six genes (KISS1, KISS1R, LIN28A, LIN28B, TAC3, and TACR3) have been known to cause early activation of the hypothalamic-pituitarygonad...