hrp0084p3-653 | Bone | ESPE2015

Late Sequel of Meningococcemia: Presenting as Skeletal Dysplasia

Karabulut Gulcan Seymen , Yuksel Aysegul Bute , Alanay Yasemin , Hatun Sukru

Background: Although there is considerable literature dealing with the diagnosis, initial management and early complications of meningococcemia, data about late complications is scarce. Growth plates may be influenced permanently by ischemia leading to late orthopedic complications such as leg length discrepancy, angular deformity and distorted body proportion. We present a patient with disproportionate short stature due to late squeal of meningococcemia who was misdiagnosed a...

hrp0086p1-p223 | Diabetes P1 | ESPE2016

The Relationship between the Serum Irisin Levels and the Metabolic Control in adolescents with Type 1 Diabetes

Yuksel Aysegul , Seymen Karabulut Gulcan , Baydemir Canan , Yesiltepe Mutlu Gul , Isgoren Serkan , Cekmen Mustafa , Hatun Sukru

Background: Irisin is an adipomyokine secreted by many tissues. Because it has known relationships with the energy metabolism and exercise, its relationships with obesity and type 2 diabetes (T2D) are being focused on. Its relationship with type 1 diabetes (T1D) is unknown.Objective and hypotheses: In this study, the relationships between the serum irisin level and the metabolic control were investigated in adolescents with T1D.Met...

hrp0082p3-d1-928 | Puberty and Neuroendocrinology | ESPE2014

Characteristics of Children Treated with Leuprolide Acetate

Karabulut Gulcan Seymen , Yuksel Aysegul , Ozsu Elif , Mutlu Gul Yesiltepe , Cizmecioglu Filiz Mine , Hatun Sukru

Objective: This study aims to reveal clinical, hormonal and ultrasound imaging features of patients treated with leuprolide acetate for diagnosis of precoccious puberty.Design: Retrospective analysis of patients with a diagnosis of central precoccious puberty and treated with leuprolide acetate between January 2008 and January 2013.Patients: 81 girls and two boys with early signs of puberty.Results: There was...

hrp0082p3-d3-950 | Puberty and Neuroendocrinology (1) | ESPE2014

Leydig Cell Hyperplasia Mimicking Tumor: a Rare Cause of Isosexual Precoccious Puberty

Karabulut Gulcan Seymen , Hatun Sukru , Yuksel Aysegul , Corapcioglu Funda Ozer , Anik Yonca , Ekingen Gulsen , Gurbuz Yesim

Background: A 5 years and 10 months boy presented with pubic hair, recent penile growth, aggressive behaviour and rapid growth of height. Antenatal, perinatal, and developmental history was unremarkable. There was no family history of precocious puberty. His height and weight were 128 cm (2.24 S.D.) and 25 kg (1.55 S.D.) respectively. Vital signs were normal. He was Tanner 2 for pubic hair and his stretched penis length was 11 cm, right testis vol...

hrp0082p3-d1-622 | Adrenals & HP Axis | ESPE2014

Body Composition Analysis in Girls With Premature Adrenarche

Nurcan Cebeci Ayse , Tas Aysegul

Background: Idiopathic premature adrenarche (PA) in girls refers to the presence of androgenic signs before the age of 8 years in the absence of thelarche. Increased adrenal androgens lead to changes in body composition and transient growth acceleration without effecting final height. Although the association between PA and some components of the metabolic syndrome is well known, total body fat and body composition analysis are not widely studied.Subject...

hrp0089p2-p163 | Fat, Metabolism and Obesity P2 | ESPE2018

Evaluation of Voiding Dysfunction in Obese Children

Nur Asilturk Havva , Ozhan Bayram , Yuksel Selcuk

Obesity is a common public health problem. Secondary complications are increasing with the increase in the prevalence of obesity. Studies on the effect of obesity on the urinary system in children continue and are limited. In this study, it was aimed to evaluate the relationship between childhood obesity and lower urinary tract dysfunction (LUTD) with metabolic and anthropometric measures. 400 obese children between 6 and 18 years of age who had a body mass index ≥95 per...

hrp0089p3-p336 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology P3 | ESPE2018

A Turkish Family with 46,XY Disorder of Sex Development Due to 17b-Hydroxysteroid Dehydrogenase Type 3 Deficiency

Gurbuz Fatih , Turan Ihsan , Tastan Mehmet , Yuksel Bilgin

17β-Hydroxysteroid dehydrogenase type 3 (17β-HSD3) is expressed mostly in the testes and converts the inactive Δ4-androstenedione (A) to testosterone (T). 17β-HSD3 deficiency is a rare autosomal recessive disorder and the most common testosterone biosynthesis defect leading to 46,XY Disorders of Sex Development (DSD). To date, more than 40 mutations of HSD17B3 have been reported. 46,XY patients with 17β-HSD3 deficiency would present with wide variable ...

hrp0086p1-p460 | Fat Metabolism and Obesity P1 | ESPE2016

The Association between Insulin Resistance and Lower Extremity Muscle Strength, Static and Dynamic Standing Balances in Obese Adolescents

Akinci Aysehan , Ersoy Yuksel , Dundar Ismaıl

Background: Obesity is characterized by insulin resistance of target tissues, such as skeletal muscle, adipose tissue and liver. Skeletal muscle tissue is responsible for approximately 75% of whole body insulin-stimulated glucose uptake. Previously, it has been shown that skeletal muscle strength is significantly associated with insulin resistance in type-2 diabetics and non-diabetics.Objective and hypotheses: To examine the relationship between insulin ...

hrp0082p2-d2-580 | Sex Development (1) | ESPE2014

The V89L Polymorphism in the SRD5A2 Gene in Cases with Undescended Testis

Yesilada Elif , Akinci Aysehan , Gulbay Gonca , Yuksel Sengul , Savaci Serap

Background: Steroid 5α-reductase catalyzes the conversion of testosterone into the more active androgen, dihydrotestosterone (DHT). In 46, XY patients with recessive mutations in steroid 5α-reductase type 2 enzyme (SRD5A2) gene, the degree of ambiguity ranges from isolated hypospadias to severe undermasculinization. SRD5A2 gene is located on chromosome 2 (p23 region) and is comprised of five exons and four introns.Objective and hypotheses: Mult...

hrp0082p3-d1-961 | Sex Development | ESPE2014

Three Siblings Extremely Androgen Insensitivity Syndrome Due to an AR Mutation with Differing Phenotypes

Yuksel Bilgin , Ucakturk Eda Mengen , Gurbuz Fatih , Topaloglu Ali Kemal

Background: Androgen insensitivity syndrome (AIS) is the most common cause of 46,XY sexual differentiation disorders. Clinical presentation is variable among cases with a range from a complete female to male external genitalia. There is a weak correlation between genotype and phenotype.Aım: Our aim is to report clinical and molecular characteristics of siblings with AIS.Patients and methods: Two siblings newborns with ambiguou...