hrp0082p2-d2-465 | Growth (1) | ESPE2014

Assessment of Omentin-1, Vaspin, and Visfatin Levels in Pediatric Patients with GH Deficiency

Sawicka Beata , Borysewicz-Sanczyk Hanna , Zasim Aneta , Jakubowska Ewa , Bossowski Artur

Introduction: GH deficiency (GHD) is a disease, in which the pituitary gland does not produce enough GH. GHD has a variety of different negative effects at different ages; e.g. it can result short stature and increased adiposity. Excessive intra-abdominal fat is associated with an increased risk of cardiovascular disease. In recent years new adipokines such as:omentin-1, vaspin, and visfatin have been described. Omentin-1 is decreased in obesity in contrast to increased vaspin...

hrp0082p3-d3-948 | Puberty and Neuroendocrinology (1) | ESPE2014

Hypothalamic Hamartoma as a Cause of Central Precocious Puberty in 4.5-Year-Old Girl: Case Report

Jakubowska Ewa , Sawicka Beata , Borysewicz-Sanczyk Hanna , Zasim Aneta , Bossowski Artur

Background: Hamartoma is a benign, focal malformation, which is composed of tissue elements normally found at that site which are arranged chaotically within the mass. It may occur in many different parts of the body and often is undetected. Hypothalamic hamartoma, unlike most such growths, is symptomatic. It may cause gelastic seisures, visual problems, rage disorders and early onset of puberty.Objective and hypotheses: A 4.5-year-old girl was hospitali...

hrp0086p2-p383 | Gonads & DSD P2 | ESPE2016

Thyroid Autoimmunity in Adolescent Girls with Polycystic Ovary Syndrome – Pilot Study

Zachurzok Agnieszka , Skrzynska Karolina , Gawlik Aneta , Malecka-Tendera Ewa

Relationship between polycystic ovary syndrome (PCOS) and thyroid autoimmunity has been recently suggested by several authors. Autoimmune thyroiditis (AIT) is the most prevalent autoimmune disease and link between AIT and PCOS has been reported in adult women. There is a hypothesis that functional autoantibodies could contribute to the development of PCOS. The aim of the study was to evaluate the prevalence of thyroid autoimmunity in adolescent girls with PCOS. Forty five adol...

hrp0092p1-373 | Growth and Syndromes (to include Turner Syndrome) (2) | ESPE2019

Matrix Metalloproteinases, their Inhibitors and Neurotrophic Factors as Indicators of Cardiometabolic Risk in Turner Syndrome Girls

Blaszczyk Ewa , Lorek Milosz , Francuz Tomasz , Gieburowska Joanna , Tokarska Agnieszka , Gawlik Aneta

Context: Turner syndrome (TS) predisposes to obesity and related disorders being a part of the metabolic syndrome. As TS population is at a higher risk of cardiovascular diseases research for laboratory markers of metabolic complications is ongoing. Based on our previous observation special significance is attributed to MMPs (matrix metalloproteinases), their inhibitors TIMPs and neurotrophic factors, such as BDNF (Brain-Derived Neurotrophic Factor) and GDNF (...

hrp0089fc15.5 | Growth and Syndromes | ESPE2018

Utility of BDNF and MMP-1 as Markers of Cardiometabolic Risk in Turner Syndrome Girls

Błaszczyk Ewa , Miłosz Lorek , Francuz Tomasz , Gieburowska Joanna , Gawlik Aneta

Background: It remains unclear whether cardiometabolic and vascular risks in Turner syndrome (TS) are the consequence of unidentified intrinsic factors or, conversely, the result of modifiable risk factors, such as overweight. New markers that could explain the pathogenesis of metabolic complications are under investigation.Objective: The comparison of the selected biochemical cardiometabolic risk markers between TS patients and healthy controls.<p c...

hrp0089p1-p239 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology P1 | ESPE2018

Sustainability of Estradiol Drug Concentrations in Cut Matrix Patches; A Study of Different Brands with Potential Use for Pubertal Induction

Ankarberg-Lindgren Carina , Gawlik Aneta , Kristrom Berit , Mazzanti Laura , Sas Theo CJ

Background: The estimated estradiol (E2) dose required for pubertal induction in hypogonadal girls is about 1/10 of the adult dose. Previous studies have shown that it is possible to provide an individualized and physiological dose for pubertal induction by cutting the patch into smaller pieces. However, the manufacturers do not guarantee stability or utility of cut E2 patches, primarily designed for postmenopausal women, and have no interest in that eval...

hrp0089p2-p350 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology P2 | ESPE2018

Psychological Gender Features and Social Abilities and in Adolescent Girls – Influence of Obesity and Hyperandrogenism

Zachurzok Agnieszka , Pasztak-Opilka Agnieszka , Forys-Dworniczak Elzbieta , Drosdzol-Cop Agnieszka , Gawlik Aneta , Malecka-Tendera Ewa

Background: Both, obesity and hyperandrogenism are the conditions that can influence many different health domains, also may affect the mental and social wellbeing components of subject’s life.Study objective: To evaluate whether body weight status and clinical hyperandrogenism may influence social competencies and psychological gender features in adolescent girls.Design & participants: In 104 adolescent girls clinical eva...

hrp0089p3-p321 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology P3 | ESPE2018

Gonadal Tumor Incidence in Patients with Disorders of Sex Development Containing Y Chromosome or Y-derived Sequences – Experience from One Clinical Center

Gawlik Aneta , Antosz Aleksandra , Drosdzol-Cop Agnieszka , Kudela Grzegorz , Koszutski Tomasz , Małecka-Tendera Ewa

Background: Risk of developing germ cell tumors (GCTs) in disorders of sex development (DSD) patients with karyotypes contain Y-chromosome or it’s material (Y) increase with age. The appropriate timing for prophylactic gonadectomy in these patients is still controversial.Aim: To analyze the gonadal tumor incidence and histological assessment of gonads in DSD (Y) patients who were treated in a single institution between 1997 and 03/2018.<p class=...

hrp0086rfc4.5 | Pathophysiology of Obesity | ESPE2016

Steroid Metabolomic Signature of Liver Disease in Childhood Obesity

Gawlik Aneta , Shmoish Michael , Hartmann Michaela F. , Malecka-Tendera Ewa , Wudy Stefan A. , Hochberg Ze'ev

Background: Analysis of steroids by gas chromatography-mass spectrometry (GC-MS) defines a subject’s steroidal fingerprint. Here, we compare the steroidal fingerprints of obese children with or without liver disease to identify the ‘steroid metabolomic signature’ of childhood non-alcoholic fatty liver disease.Methods: Urinary samples of 85 children (43 girls) age 8.5–18.0 with obesity (BMI >97%) were quantified for 31 steroid meta...

hrp0082p2-d2-329 | Diabetes (1) | ESPE2014

Lipid Profile is Related to Androgen Level in Adolescent Girls with Type 1 Diabetes Mellitus

Zachurzok Agnieszka , Deja Grazyna , Gawlik Aneta , Drosdzol-Cop Agnieszka , Malecka-Tendera Ewa

Background: The mechanisms underlying dyslipidaemia in the context of polycystic ovary syndrome may include not only metabolic aberrations but also hormonal factors, in particular hyperandrogenaemia.Objective and hypotheses: The aim of the study was to establish whether dyslipidaemia and metabolic control disturbances are related to hyperandrogenaemia in adolescent girls with type 1 diabetes mellitus (T1DM).Method: We studied 54 gi...