ESPE Abstracts

Pediatric obesity remains an ongoing serious international health concern affecting about 17% of children and adolescents in the United States while worldwide over 41 million children under 5 years are overweight or obese, threatening their adult health and longevity. Pediatric obesity has its basis in genetic susceptibilities influenced by a permissive environment starting in utero and extending through childhood and adolescence. Endocrine etiologies for obesity are rare and ...

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Background: The skeleton, which is strongly controlled by endocrine factors, has recently been shown to play an active endocrine role itself, specifically influencing energy metabolism. However, its role in polycystic ovary syndrome (PCOS) phenotype is underinvestigated.Aim: Herein, we sought to identify novel factors involved in the regulation of both bone mass and whole-body homeostasis relevant to the disease.<p c...

Background: The polycystic ovary syndrome (PCOS) is believed to contribute to adverse cardiovascular effects.Aim: The aim of the present study was to investigate the potential alterations in heart rate variability (HRV) pattern in adolescent patients with polycystic ovary syndrome (PCOS).Methods: Nineteen PCOS adolescent patients group (mean age 16.8 ± 3.2 years) and twenty on...

This prospective population study focuses on metabolic differences between adolescent patients with polycystic ovary syndrome (PCOS) and age/BMI matched non-PCOS controls recruited by the Centre for Adolescent Medicine and UNESCO Chair on Adolescent Health Care of the First Department of Paediatrics, at the ‘Aghia Sophia’ Children’s Hospital, in Athens, Greece. Bioimpendance is an established non-interventional method for the determination of the body compositio...

Background: Early gain in fat mass (FM) might be influenced by type of feeding. Excessive gain in FM during the first three months of life is associated with an increased risk for adiposity and cardiovascular diseases. This three-month period is also known as the critical window for adiposity programming.Aims: To investigate differences in body composition between exclusively breastfed (BF) and formula fed (FF) infants from birth to 24 months.<p clas...

This case control study aims at investigating the cardiovascular profile of Greek adolescents suffering from polycystic ovary syndrome (PCOS) by comparing them with age- and body mass index (BMI)- matched non-PCOS controls. Nineteen PCOS patients and eighteen non-PCOS controls (aged 13 to 23 years) were studied for: (i) bioreflex sensitivity (BRS), as a marker of cardiac function, (ii) carotid pulse pressure (PP) and subendocardial viability ratio (SEVR), as markers of arteria...

Background: Prader–Willi Syndrome (PWS) is a complex genetic disease; one hallmark of the disease is failure to regulate hunger and metabolism. Hyperphagia and severe obesity contribute significantly to the morbidity and mortality of this disease. Methionine aminopeptidase 2 (MetAP2) inhibition reduces fat biosynthesis and stimulates fat oxidation and lipolysis. Beloranib is a selective and potent MetAP2 inhibitor. In a 4-week phase 2, placebo-controlled, proof-of-concept...

Background: The new adipokine/myokine meteorin-like (Metrnl) has been proposed to be of interest for obesity and metabolic disease through its potential role for brown/beige fat thermogenesis and macrophage activation in mice. METRNL was reported to be expressed in white adipose tissue (AT) and upregulated during adipogenesis and by exercise and.Aims: In this study we analysed the expression of METRNL during human adipogenesis and its regulation...

Background: Excessive gain in fat mass (FM) during the first months of life, known as the critical window for adiposity programming, is associated with an increased risk for adiposity and cardiovascular diseases in later life. Early life nutrition (breastfeeding or formula feeding) might influence body composition (FM and fat free mass (FFM)) development in early life.Aims: To investigate differences in sex-specific long...