Purpose: To analyze the effects of clinical and laboratory factors, including insulin-like growth factor (IGF) levels, on the height velocity of normal prepubertal children.
Methods: Ninety-five healthy prepubertal children (33 boys, 62 girls) were enrolled. The mean chronological age of the participants was 6.3±1.4 years, with a height standard deviation score (SDS) of −0.88±0.70. IGF-1, IGF binding protein-3 (IGFBP-3), SDS for anthropometric measurements, and changes in SDS for anthropometric measurements were analyzed for one year, and their associations with one-year height velocity were investigated.
Results: The group of children with a one-year height velocity of ≥6 cm were chronologically younger than the group with a one-year height velocity of <6 cm (5.9±1.3 vs 6.7±1.3 years, P=0.004), with a lesser increase of SDS for body mass index (BMI) over one year (−0.18±0.68 vs 0.13±0.53, P=0.014). There were no differences between the two groups in IGF-1 SDS and IGFBP-3 SDS. Multiple linear regression showed that baseline chronological age (r=0.243, P=0.026) and height SDS (r=0.236, P=0.030) were positively associated with IGF-1 SDS. Binomial logistic regression showed that an increase in chronological age (odds ratio (OR), 0.68; 95% CI, 0.470.99) and an increase of BMI SDS over one year (OR, 0.41; 95% CI, 0.180.89) were associated with a decreased growth possibility of an above-average height velocity (≥6 cm/year).
Conclusion: Height velocity of normal prepubertal children is affected by an increase of BMI SDS and chronological age. Prepubertal IGF-1 SDS reflects height SDS at the time of measurement but is not associated with subsequent height velocity.
27 - 29 Sep 2018
European Society for Paediatric Endocrinology