Objective: We sought to evaluate the role of long-term HRT on the lipid profile and glucose metabolism in girls with TS.
Design: A pre-test/post-test observational study.
Seting: Pediatric TS clinic in The First Affiated Hospital, Sun Yat-sen University.
Patients: 56 girls with TS had accurate maintenance HRT data.
Main outcome measures: Parameters of health surveillance derived from clinical guidelines.
Results: Lipid parameters did not differ during the 5 years of follow-up based on HRT or artificial cycles. Fasting glucose significantly decreased starting in the first year of HRT (P 1st yr = 0.026; P 2nd yr = 0.018; P 3rd yr = 0.005; P 5th yr= 0.041), and the fasting insulin level and homeostasis model assessment of insulin resistance (HOMA-IR) were significantly lower starting in the second year than those values before HRT (serum insulin: P 2nd yr = 0.046; P 3rdyr = 0.032; P 5th yr= 0.008; and HOMA-IR: P 2nd yr = 0.037; P 3rdyr = 0.014; P 5th yr = 0.006, respectively).
Conclusion: Sex steroid HRT was beneficial for glucose metabolism in long-term follow-up, particularly after 1 year of treatment. HRT did not affect lipid metabolism in girls with TS. Use of artificial cycles did not affect the glucose or lipid profile.
19 - 21 Sep 2019
European Society for Paediatric Endocrinology