ESPE Abstracts (2019) 92 P2-114

Five Years' Follow-up of the Effect of Sex Steroid Hormone on Lipid and Glucose Metabolism in Girls with Turner Syndrome

Song Guo, Yanhong Li, Jun Zhang, Qiuli Chen, Huamei Ma, Hongshan Chen, Minlian Du

The First Affiliated Hospital, Sun Yat-sen University, China

Objective: We sought to evaluate the role of long-term HRT on the lipid profile and glucose metabolism in girls with TS.

Design: A pre-test/post-test observational study.

Seting: Pediatric TS clinic in The First Affiated Hospital, Sun Yat-sen University.

Patients: 56 girls with TS had accurate maintenance HRT data.

Main outcome measures: Parameters of health surveillance derived from clinical guidelines.

Results: Lipid parameters did not differ during the 5 years of follow-up based on HRT or artificial cycles. Fasting glucose significantly decreased starting in the first year of HRT (P 1st yr = 0.026; P 2nd yr = 0.018; P 3rd yr = 0.005; P 5th yr= 0.041), and the fasting insulin level and homeostasis model assessment of insulin resistance (HOMA-IR) were significantly lower starting in the second year than those values before HRT (serum insulin: P 2nd yr = 0.046; P 3rdyr = 0.032; P 5th yr= 0.008; and HOMA-IR: P 2nd yr = 0.037; P 3rdyr = 0.014; P 5th yr = 0.006, respectively).

Conclusion: Sex steroid HRT was beneficial for glucose metabolism in long-term follow-up, particularly after 1 year of treatment. HRT did not affect lipid metabolism in girls with TS. Use of artificial cycles did not affect the glucose or lipid profile.

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