Background: we depicted gender-differences in metabolic syndrome (MS) clustering before and after puberty in pediatrics, to identify early childhood prevention intervention and treatments.
Methods: We considered 1079 children and adolescents. According to body mass index (BMI) percentiles the subjects were classified as normal weight BMI<75th, overweight BMI 75-95th and with obesity BMI>95th. MS was diagnosed when 3 of the following criteria for age and sex percentiles were met: BMI<95th, tryglicerides level>95th, HDL-cholesterol level<5th, blood pressure>95th percentile, fasting blood glucose>100 mg/dl and/or HOMA-IR >97.5th percentile.
Results: The prevalence of dismetabolic factors was similar in both genders, except for pathological BP, higher in males (P=0.02). MS was detected only in patients with obesity, with an higher prevalence in pubertal than pre-pubertal subjects (P=0.01), without any significant difference between gender. In prepuberty, the most common MS combination was obesity (HBMI)+hypertension (HBP)+hyperglycemia/insulin resistance (HGLY/IR) followed by HBMI+low HDL-levels (LHDL) + HGLY/IR versus HBMI+HBP+ HGLY/IR followed by HBMI+HBP+LHDL respectively in females and males. In pubertal period, the combination HBMI+HBP+ LHDL+ HGLY/IR was present in both genders.
Conclusion: we confirm that MS is an important consequence related to obesity, particularly in post-puberty stage. Some gender-based differences may be early considered in order to define specific preventive and treatment strategies.
19 - 21 Sep 2019
European Society for Paediatric Endocrinology