ESPE2019 Poster Category 3 Fat, Metabolism and Obesity (35 abstracts)
Gender-Based Differences in the Clustering of Metabolic Syndrome Factors in Children and Adolescents
Valeria Calcaterra 1 , Corrado Regalbuto 2 , Federica Vinci 2 , Chiara Montalbano 2 , Giulia Dobbiani 2 , Annalisa De Silvestri 3 , Hellas Cena 2 & Daniela Larizza 4
1university of Pavia and Fond. IRCCS Policlinico San Matteo, Pavia, Italy. 2University of Pavia, Pavia, Italy. 3Fond. IRCCS Policlinico San Matteo, Pavia, Italy. 4University of Pavia and Fond. IRCCS Policlinico S. Matteo, Pavia, Italy
Background: we depicted gender-differences in metabolic syndrome (MS) clustering before and after puberty in pediatrics, to identify early childhood prevention intervention and treatments.
Methods: We considered 1079 children and adolescents. According to body mass index (BMI) percentiles the subjects were classified as normal weight BMI<75th, overweight BMI 75-95th and with obesity BMI>95th. MS was diagnosed when 3 of the following criteria for age and sex percentiles were met: BMI<95th, tryglicerides level>95th, HDL-cholesterol level<5th, blood pressure>95th percentile, fasting blood glucose>100 mg/dl and/or HOMA-IR >97.5th percentile.
Results: The prevalence of dismetabolic factors was similar in both genders, except for pathological BP, higher in males (P=0.02). MS was detected only in patients with obesity, with an higher prevalence in pubertal than pre-pubertal subjects (P=0.01), without any significant difference between gender. In prepuberty, the most common MS combination was obesity (HBMI)+hypertension (HBP)+hyperglycemia/insulin resistance (HGLY/IR) followed by HBMI+low HDL-levels (LHDL) + HGLY/IR versus HBMI+HBP+ HGLY/IR followed by HBMI+HBP+LHDL respectively in females and males. In pubertal period, the combination HBMI+HBP+ LHDL+ HGLY/IR was present in both genders.
Conclusion: we confirm that MS is an important consequence related to obesity, particularly in post-puberty stage. Some gender-based differences may be early considered in order to define specific preventive and treatment strategies.
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