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58th Annual ESPE

Vienna, Austria
19 Sep 2019 - 21 Sep 2019

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The theme of this year’s meeting is Variety and Variation in Paediatric Endocrinology. Join us in Vienna to explore the diversity we encounter in our discipline and the care that we have to exercise when using the term “normality”. Whilst gaining an update on the latest treatments, clinical best practice and cutting edge research in the field of paediatric endocrinology.

Poster Category 3

Fat, Metabolism and Obesity

hrp0092p3-96 | Fat, Metabolism and Obesity | ESPE2019

Assessment of Cardiac Function in Obese Children and Adolescents with Metabolic Syndrome

Tragomalou Athanasia , Kosti Evangelia , Sveroni Konstantina , Loukopoulou Sofia , Binou Maria , Kourlaba Georgia , Papadopoulou Marina , Kassari Penio , Charmandari Evangelia

Background: Obesity in childhood and adolescence is often associated with dyslipidemia, hypertension, insulin resistance, inflammation, and disturbances in adipocytokine secretion, which lead to endothelial dysfunction and the development of atherosclerotic cardiovascular disease.Aim: To determine the prevalence of metabolic syndrome (MS) among obese children and adolescents attending our out-patient childhood obesity cl...

hrp0092p3-97 | Fat, Metabolism and Obesity | ESPE2019

Metabolic Syndrome in Adults with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency

Gargouri Imen , Hadjkacem Faten , Safi Wajdi , Ghorbel Dorra , Nabila Rekik , Nadia Charfi , Kamoun Thouraya , Mnif Mouna , Abid Mohamed

Introduction: 21-Hydroxylase deficiency is the most frequent form of congenital adrenal hyperplasia (CAH) which is a common autosomal recessive disorder characterized by impaired adrenocortical and adrenomedullary function, and adrenal hyperandrogenism. Chronic glucocorticoid therapy and excess androgen exposure in patients with CAH may predispose them to developing a metabolic syndrome in adulthood.Our objective is to evaluate the metabolic syndrome in adulth...

hrp0092p3-98 | Fat, Metabolism and Obesity | ESPE2019

High Allostatic Load in Children with Excess of Weight

Calcaterra Valeria , Montalbano Chiara , Vinci Federica , Regalbuto Corrado , Casari Giulia , De Silvestri Annalisa , Cena Hellas , Larizza Daniela

Objective: Allostatic load (AL) refers to the physiological response that occurs in chronic stress burden, Excessive weight gain is an important source of physiological stress promoting chronic low-inflammation state detrimental for health. We estimated AL score among a pediatric population, in order to define a correlation between cumulative biological dysregulation and excess weight.Methods: We enrolled 164 children an...

hrp0092p3-99 | Fat, Metabolism and Obesity | ESPE2019

"Influence of Eating Habits, Sleep Patterns and Physical Activity on Anthropometric Variables and Body Composition in Children with Obesity"

Gavela-Pérez Teresa , De Dios Olaya , Herrero Leticia , Pérez-Segura Pilar , Garcés Carmen , Soriano-Guillén Leandro

Objectives: The etiopathogenetic of childhood obesity is related to genetic and environmental factors: not only caloric intake or physical activity have an important influence, but also circadian rhythms, including healthy sleep.The objectives of this study were: a) to analyze the different patterns and duration of sleep, eating habits, meal schedules, time dedicated to exercise and screens of obesity children; b) to evaluate its possibl...

hrp0092p3-100 | Fat, Metabolism and Obesity | ESPE2019

An Infant with Severe Hypertriglyceridemia: Acute and Long-Term Management in the Paediatric Population

Poon Sarah WY , Tsang Anita MC , Poon Grace WK , Tung Joanna YL

Background: Severe hypertriglyceridemia, defined as triglyceride concentration greater than 11.2 mmol/L, predisposes to acute pancreatitis, a serious complication with mortality rate as high as 6.5% in children (1).Our case highlights the use of insulin infusion to rapidly lower the triglyceride level and the long term management in a young infant with familial chylomicronemia syndrome (FCS) due to lipoprotein lipase deficiency.<stro...

hrp0092p3-101 | Fat, Metabolism and Obesity | ESPE2019

BigO: The use of New Technologies for the Management of Childhood Obesity – A Clinical Pilot Study

Tragomalou Athanasia , Kassari Penio , Ioakeimidis Ioannis , Filis Konstantinos , Theodoropoulou Eleni , Lymperopoulos Giorgos , Perez Cuevas Isabel , Karavidopoulou Youla , Diou Christos , Maramis Christos , Lekka Eirini , Maglaveras Nicos , Delopoulos Anastasios , Charmandari Evangelia

Background: Obesity represents one of the most challenging public health problems of the 21st century. According to the World Health Organization (WHO), there is a need to create reliable monitoring and behavioral systems, and to investigate their effectiveness in preventing childhood obesity.Objective: To evaluate a range of novel technologies for collecting photographs, information regarding physical activity and geogr...

hrp0092p3-102 | Fat, Metabolism and Obesity | ESPE2019

Obesity and Insulin Resistance: Differences Between Pubertal and Prepubertal Children

Dikaiakou Eirini , Vlachopapadopoulou Elpis-Athina , Athanasouli Fani , Stergiotis Stefanos , Kafetzi Maria , Fotinou Aspasia , Michalakos Stefanos

Introduction: The presence of insulin resistance in obese children is strongly related to severity of obesity. Furthermore, insulin resistance is exacerbated during puberty, mainly due to increased sex steroids and growth hormone secretion.Objective: To compare obesity and insulin resistance indicators between pre-adolescent and adolescent children.Methods: 54 pre-adolescent and 41...

hrp0092p3-103 | Fat, Metabolism and Obesity | ESPE2019

Relationship Between 25-Hydroxyvitamin D with Adiposity Assessed by Body Mass Index, Serum Glucose and Lipids Levels in Korea: A Cross-Sectional Analysis

Shim Kye Shik , Cho Ja Hyang , Jung Hae Woon

Purpose: Vitamin D deficiency is thought to be influenced by cardiovascular function and glucose homeostasis, however the potential influence of vitamin D status on insulin resistance, is not well understood. The aim is investigate the correlations between 25-hydroxyvitamin D[25(OH)D] with adiposity assessed by body mass index(BMI), fasting glucose and lipid levels on schoolchildren.Methods: From April 2015 to July 2018,...

hrp0092p3-104 | Fat, Metabolism and Obesity | ESPE2019

Treating Paediatric Morbid Obesity using the Multidisciplinary Intensive Inpatient Approach

Deshpande Ruma , Easter Shelley , Semple Claire , Wenn Melanie , Luther Sarah , Augustus Rhian , Hamilton - Shield Julian , Giri Dinesh

Background: Interplay of various factors contribute to development of morbid childhood obesity and to its recalcitrant nature making it a treatment challenge. A tertiary level, structured multidisciplinary outpatient approach may not always be sufficient in identifying morbid obesity causation. In the absence of other effective treatment modalities, a hospital stay approach can be a suitable option in selected resistant cases.Met...

hrp0092p3-105 | Fat, Metabolism and Obesity | ESPE2019

The Interaction Between Lipids Regulatory Genes Polymorphism and Obesity on Cardiometabolic Risk Factors in Children and Adolescents

Hashemipour Mahin , Hovsepian Silva , Kelishadi Roya

Objectives: It is suggested that interaction of dyslipidemia related polymorphisms with obesity is one of the possible mechanisms of expression of cardiometabolic risk factors in obese children. In this study, in order to classify high risk obese children and consequently prioritize health care resources for better management of childhood obesity,we investigated the outcome of GCKR(rs780094), GCKR(rs1260333), MLXIPL(rs3812316) and FADS(<a href="http://www.ncbi...

hrp0092p3-106 | Fat, Metabolism and Obesity | ESPE2019

Phenotypic and Genotypic Properties of Children with Suspicion of Monogenic Obesity

Ayranci Ilkay , Çatli Gönül , Eroğlu Filibeli Berna , Yiğit Gülşahin Elif , Özyilmaz Berk , Manyas Hayrullah , Nuri Dündar Bumin

Results: Total of 47 obese patients (20 females, 39 pubertals, mean age of 14.3 years).±3.2 years) were included in the study. Severe obesity present in 85% of patients, early-onset obesity in 51%, consanguinity among parents in 17%, and at least one parent with obesity in 63.8% were present. 55.3% of the patients had a family history of diabetes, 63% had acanthosis nigricans and 77% had striae. Anthropometric and laboratory ch...

hrp0092p3-107 | Fat, Metabolism and Obesity | ESPE2019

Relation of Serum 25 Hydroxy-Vitamin Levels D3 with Body-Mass Index in Pediatric Patients

Ventura Wichner Paula Sol , Bosch Zelmira , Grigolato Anabella , Del Valle Rossi Romina , Fornells Eduard , LaCruz Marisa Torres

Background: The aim of our study is to determine the relation of vitamin D levels (25(OH)VD) with body-mass index (BMI), age and month of extraction in pediatric patients.Materials and Methods: We present a retrospective review of medical records of patients under 18 years of age visited by the Children's Endocrinology Service (overweight and obesity) and ambulatory pediatrics (healthy and normal weight children) at ...

hrp0092p3-108 | Fat, Metabolism and Obesity | ESPE2019

Vitamin B12 Levels in Children After Metformin Treatment

Yordanova Desislava , Todorova Zdravka , Dimitrova-Mladenova Mihaela , Stefanova Elisaveta

Background and Aims: Vitamin B12 is an essential micronutrient required for optimal hemopoetic, cardiovascular and neuro-cognitive functions. There are some literature data that Metformin induces vitamin B12 malabsorption, which may increase the risk of developing vitamin B12 deficiency and subsequently elevation of homocysteine levels. High concentrations of homocysteine has been associated with higher risk of coronary artery disease, arterial hypertension, h...

hrp0092p3-109 | Fat, Metabolism and Obesity | ESPE2019

Follow-Up Evaluation of Clinical Markers and Inflammatory, Biochemical and Hormonal Profiles in Children with Bodyweight Problems

Ṭaranu Ioana , Bolboacă Sorana D. , Creţ Victoria

Introduction: In the last years, the relationship between clinical markers and blood parameters has been evaluated closely as part of transversal studies, but a longitudinal approach might be more useful in explaining its complexity.Aim: The study aims to evaluate the relationship between changes in the values of clinical markers and of the inflammatory, biochemical and hormonal profiles of obese and overweight children ...

hrp0092p3-110 | Fat, Metabolism and Obesity | ESPE2019

Gastroduodenopathies in Obese Young People

Aharkov Serhii , Tolstikova Olena

Aim: To study of the pathology of the upper gastrointestinal tract in obese young people.Materials and Methods: 87 young people with primary obesity (body mass index above 30 kg / m²), 40 boys (45.9%), mean age 17.9 ± 2.2 years (group 1) were under observation. Conducted clinical, laboratory and instrumental examination, esophagogastroduodenoscopy, Ph-metry and determination of H.Pylori infection. The 2nd g...

hrp0092p3-111 | Fat, Metabolism and Obesity | ESPE2019

Seven Methods of Indicating Childhood Metabolic Syndrome

koohmanaee shahin , dalili setila , hassanzadeh rad afagh , Forough Jafari Seyyedeh

Introduction and Aims: Metabolic syndrome (METs) has different complications such as cardiovascular diseases and diabetes type 2. There is no uniform definition for METs. In this study, we aimed to define METs from different viewpoints to determine the most appropriate method that could be used for early METs diagnosis in general population and treat them immediately.Materials and Methods: This study was an analytic cros...

hrp0092p3-112 | Fat, Metabolism and Obesity | ESPE2019

Insulin Resistance in Children and Adolescents with Exogen-Constitutional Obesity

Azimova Shakhnoza , Rakhimova Gulnara

Objective: evaluate insulin resistance (IR) in children and adolescents with exogen-constitutional obesity (ECO) depending on the stage of sexual development.Materials and research methods: 100 children and adolescents with ECO of the UzBek population from 6 to 16 years were observed (mean age 11.7 ± 0.25 years). The control group consisted of 71 healthy children of the appropriate age (mean age 11.1 ± 0.33 yea...

hrp0092p3-113 | Fat, Metabolism and Obesity | ESPE2019

Severe Hypernatremia Revealing A Rohhad-Net Syndrome

Ouarezki MEDICAL/HEALTH , Bouferoua Fadila , Djermane Adel , Boucenna Hamza , Boukhedouma Nabila , El-Mokhtar Mohamed , Maouche Hachemi , Benhalla Nafissa , Tayebi Youcef

Introduction: Rapid-onset Obesity with Hypoventilation, Hypothalamic dysfunction and Autonomic Dysregulation (ROHHAD) recently named ROHHAD-NeuroEndocrine Tumors (ROHHAD-NET) syndrome is a rare cause of obesity in children. The diagnosis is challenging and can easily be confused with other causes of obesity.Case Report: We report a case of a six-year-old boy, referred to our clinic for hypernatremia. Six months ago, he s...

hrp0092p3-114 | Fat, Metabolism and Obesity | ESPE2019

Rare Case of Acquired Generalized Lipodystrophy in A 14-Year Old Patient

Cristina Patricia Dumitrescu , Monica Mailat

Background: Lipodystrophies are a group of rare disorders characterized by varying degrees of body fat loss. The metabolic abnormalities associated with lipodystrophy include insulin resistance, often leading to diabetes mellitus, hypertriglyceridemia that may be severe enough to cause acute pancreatitis and hepatic steatosis that may lead to cirrhosis.They can be either genetic or acquired, generalized or partial. Acquired generalized l...

hrp0092p3-115 | Fat, Metabolism and Obesity | ESPE2019

Gender-Based Differences in the Clustering of Metabolic Syndrome Factors in Children and Adolescents

Calcaterra Valeria , Regalbuto Corrado , Vinci Federica , Montalbano Chiara , Dobbiani Giulia , De Silvestri Annalisa , Cena Hellas , Larizza Daniela

Background: we depicted gender-differences in metabolic syndrome (MS) clustering before and after puberty in pediatrics, to identify early childhood prevention intervention and treatments.Methods: We considered 1079 children and adolescents. According to body mass index (BMI) percentiles the subjects were classified as normal weight BMI<75th, overweight BMI 75-95th and with obesity BMI>95th....

hrp0092p3-116 | Fat, Metabolism and Obesity | ESPE2019

Fat Mass Index and Fat-free Mass Index Percentiles in Healthy Spanish Adolescents

Durá-Travé Teodoro , Chueca-Guindulain María , Berrade-Zubiri Sara , Malumbres-Chacón María , Moreno-González Paula

Background: Body mass index not allow to discriminate the proportional composition of the different body compartments: fat mass and fat-free massObjective: The aim of this study is to elaborate standardized values of the fat mass index (FMI) and fat-free mass index (FFMI) in healthy adolescents (both sexes) using anthropometric techniques in order to be available as reference standards in daily clinical practice.<p c...

hrp0092p3-117 | Fat, Metabolism and Obesity | ESPE2019

Comparison of Different Criteria for the Definition of Insulin Resistance and Its Relation with Metabolic Risk in Overweight and Obese Adolescents

Lee Seonhwa , Choi Yujung , Kim Seulki , Lee Nayeong , Lee Yoonji , Ahn Moonbae , Kim Shinhee , Cho Wonkyoung , Cho Kyoungsoon , Jung Minho , Suh Byungkyu

This study aimed to compare cut-off points corrected for age and gender (CCOP) with fixed cut-off points (FCOP) for fasting plasma insulin and homeostasis model assessment-insulin resistance (HOMA-IR) for the diagnosis of IR in Korean obese children and adolescents and to identify IR applying CCOP and FCOP using as outcome the presence of dyslipidemia and Metabolic syndrome (MetS).We performed a cross sectional analysis of data from 195 adolescents aged ...

hrp0092p3-118 | Fat, Metabolism and Obesity | ESPE2019

Somatostatine Analogue in Hypothalamic Obesity

Haliloglu Belma

Hypothalamic Obesity (HyOb) is the most flagitious endocrinologic problem following surgical intervention for childhood brain tumors. There is still no curative therapy for HyOb.A 4y 10/12 m old girl presented with headache and vomiting. Pituitary MRI revealed a craniopharyngioma and she was operated. The replacement therapies for postop panhypopituitarism was given but she developed HyOb within 4 months after operation (table-1). Somatostatin analogue (...

hrp0092p3-119 | Fat, Metabolism and Obesity | ESPE2019

ESPE 2019. Physical Activity, Food and Metabolic Risk in Children and Adolescents

de Lamas Carmela , Vázquez Rocío , José Bedoya Juan , Aguilera Concepción , Gil-Campos Mercedes , Bueno Gloria , Moreno Luis , Gil Ángel , Leis Rosaura

Introduction:The incidence of obesity increases unstoppably in all populations and at all ages, and with it, the associated metabolic morbidity and mortality. The promotion of physical activity and a healthy diet are the fundamental elements to alleviate this situation. The objective of this study is to determine the relationship of physical activity and eating patterns with body composition, the degree of adiposity and certain metabolic risk factors.<p cl...

hrp0092p3-120 | Fat, Metabolism and Obesity | ESPE2019

Toward a Simple Marker of Hepato-Visceral Adiposity and Insulin Resistance:The Z-Score Change from Weight-at-Birth to BMI-in-Childhood

Malpique Rita , de Zegher Francis , Garcia-Beltran Cristina , Ibáñez Lourdes

Insulin resistance and hepato-visceral (central) fat excess are thought to contribute to an earlier timing of adrenarche/pubarche and puberty/menarche; this earlier timing in turn relates often to a mismatch between pre- and postnatal weight gain, which can be estimated by calculating the Z-score change from birth weight (BW) to body mass index (BMI) in childhood. We tested the hypothesis that this calculation may serve as a proxy of insulin resistance and hepato-visceral adip...

hrp0092p3-121 | Fat, Metabolism and Obesity | ESPE2019

Associations Between Lipid Parameters and Insulin Resistance in Obese Adolescents

Chaychenko Tetyana , Kharkova Mariia , Rybka Olena

Background: Non-communicable disease epidemic is directly related to the dislipidemia and insulin resistance (IR) that associated with acute cardiovascular events. Meanwhile, there is not much has known about interrelation between this parameters in pediatric patients.Purpose: of the study is to analyze associations between lipids and insulin resistance so as to screen high risk subjects during adolescence.<p class="...

hrp0092p3-122 | Fat, Metabolism and Obesity | ESPE2019

The Characteristic of Thyroid Status in Overweight and Obese Young People with Insulin Resistance

Tolstikova Olena , Aharkov Serhii

Introduction: Due to the widespread occurrence of both obesity and hypothyroidism, physicians need to be especially attentive to the possible thyroid dysfunction in obese patients. The relationship between thyroid hormones and obesity in combination with insulin resistance in young people is not fully understood.Materials and Methods: In order to study of thyroid status in young people with overweight and obesity in comb...

hrp0092p3-123 | Fat, Metabolism and Obesity | ESPE2019

Validity of Non-High-Density Lipoprotein Cholesterol for Detecting Dyslipidemia Among Korean Adolescents

Nam Hyo-Kyoung , Yoojin Lindsey , Huh Rimm , Rhie Young-Jun , Lee Kee-Hyoung

Objectives: Non-high-density lipoprotein (HDL) cholesterol is an alternative method to assess dyslipidemia and is not required fasting. We aimed to assess the validity of non-HDL cholesterol for detecting dyslipidemia among Korean adolescents.Subjects and Methods: Data for 6,989 adolescents aged 10 to 19 years (3,684 boys and 3,305 girls), were obtained from the Korean National Health and Nutrition Examination Surveys du...

hrp0092p3-124 | Fat, Metabolism and Obesity | ESPE2019

Early Onset Monogenic Obesity: Two Cases with Homozygous Mutation in Lepr Gene

Nalbantoglu Ozlem , Acar Sezer , Koprulu Ozge , Arslan Gulcin , Ozkaya Beyhan , Hazan Filiz , Gursoy Semra , Ozkan Behzat

Introduction: Although the majority of the cases with obesity have a multifactorial etiology, rare monogenic forms of obesity exist. Several genetic disorders have been described that lead to early onset monogenic obesity. Leptin (LEP), leptin receptor (LEPR), melanocortin 4 receptor (MC4R), proprotein converting protein subtilisin / kexin-type 1 (PCSK1) and proopiomelanocortin (POMC) are the genetic mutations that have been most frequently shown to cause mono...

hrp0092p3-125 | Fat, Metabolism and Obesity | ESPE2019

Fasting C-Peptide: A Useful Tool for Diagnosis of Type II Diabetes Mellitus in Overweight / Obese Adolescents Living in a Poor Resources Setting

Bodieu Chetcha Adele , Fomenky Njiandock Cecilia , Dehayem Mesmin , Sobngwi Eugene

Case Report: Two cases of type 2 diabetes mellitus (among which 1 case of metabolic syndrome) previously taken as type 1 diabetes mellitus in adolescents are presented and the evaluation and management are discussed. There was a family history of Diabetes mellitus in one of the adolescent. Both of them had signs of insulin resistance, they were overweight and obese respectively, poorly controlled on premix insulin. The laboratory test revealed a high HbA1C, dy...

hrp0092p3-126 | Fat, Metabolism and Obesity | ESPE2019

Metabolic Risk Assessment in Obese Children Using Hypertriglyceridemic Waist (HTGW) Phenotype. Can it be a Useful Screening Marker?

Dikaiakou Eirni , Vlachopapadopoulou Elpis-Athina , Athanasouli Fani , Stergiotis Stefanos , Kafetzi Maria , Fotinou Aspasia , Michalacos Stefanos

Background: The prevalence of childhood obesity is dramatically increasing worldwide. Overweight and obesity are well known risk factors for metabolic disorders such as Insulin Resistance, Type II Diabetes, Arterial Hypertension and Non Alcoholic Fatty Liver Disease (NAFLD).Aims: This study was conducted to assess the prevalence of Hypertriglyceridemic Waist phenotype (HTGW) among overweight and obese Greek children. Fur...

hrp0092p3-127 | Fat, Metabolism and Obesity | ESPE2019

Rosuvastatain Therapy in Children with Heterozygous Familial Hypercholesterolemia, Efficacy, and Security of Low Régimen of Therapy

Awadalla Shokery

Introduction: Heterozygous familial hypercholesterolemia is as frequent as 1: 200-500, and the mortality risk is four times more than unaffected children.Nutritional therapy in addition to physical activity can help but is not enough to avoid later morbidity and mortality. Stations have shown efficacy in children, but we do not have enough data for long term safety.Aim: to compare tow regimens of therapy using rosuvastat...

hrp0092p3-128 | Fat, Metabolism and Obesity | ESPE2019

Lipid and Glucose Profiles in Obese Algerian Children and Adolescents

Kerkouche Soraya , Ladjouze Asmahane , Haddad Naima , Bouzerar Zahir

Introduction: Obesity constitutes a risk factor for several early-onset metabolic disorders. The problem is escalating in Africa, where the number of obese or overweight children and adolescents has increased byalmost 50% since 2000 according to World Health Organisation (WHO) data).Objectives: To determine the lipid and glucose profiles in Algerianchildren adolescents with obesity, defined as body mass index (BMI) &...

hrp0092p3-129 | Fat, Metabolism and Obesity | ESPE2019

Influence of Anthropometric Indices at Birth on Obesity Characteristics in School-Age Children

Latyshev Dmitry , Latyshev Oleg , Lobanov Yuri , Karkova Tatyana

Influence of anthropometric indices at birth on obesity characteristics in school-age children Latyshev D. Yu., Lobanov Yu. F.? Latyshev O. Yu. *, Karkova T.A. Altai State Medical University, Barnaul * Russian Medical Academy of Postgraduate Education. Moscow Keywords: obesity, children, body length, body mass index Objective: To study the relationship between anthropometric data at birth and the course of obesity in school-age children. Materials and metho...

hrp0092p3-130 | Fat, Metabolism and Obesity | ESPE2019

Acanthosis Nigricans as a Presentation of Severe Insulin Resistance in Obese Children

Krajewska Maria , Nowaczyk Jędrzej , Labochka Dominika , Kucharska Anna

Acanthosis nigricans is a common skin presentation of insulin resistance. We may observe different forms of its sevirity. Pathogenesis of this disorder is correlated with an action of insulin to keratinocyte and dermal fibroblasts via interaction with IGFR1.We'd like to present a medical history of two patients admitted to our clinic because of severe acanthosis nigricans. Boys were at the age of 13 and 14 years. We diagnosed carbohydrate metabolism ...