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58th Annual ESPE

Vienna, Austria
19 Sep 2019 - 21 Sep 2019

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The theme of this year’s meeting is Variety and Variation in Paediatric Endocrinology. Join us in Vienna to explore the diversity we encounter in our discipline and the care that we have to exercise when using the term “normality”. Whilst gaining an update on the latest treatments, clinical best practice and cutting edge research in the field of paediatric endocrinology.

Poster Category 3

Diabetes and Insulin

hrp0092p3-47 | Diabetes and Insulin | ESPE2019

Serum Catecholamines in Children With Type 1 Diabetes Mellitus

Osokina Irina

Background: young children with type 1 diabetes mellitus (DM1) have a tendency to recurrent hypoglycemia. Increased sensitivity to insulin in young diabetes patients may be associated with features of secretion of catecholamine, particularly adrenaline.The aim: to explore the basal levels of catecholamine (epinephrine, norepinephrine, and dopamine) in serum of young children with type 1 diabetes mellitus to identify of p...

hrp0092p3-48 | Diabetes and Insulin | ESPE2019

Oral Glucose Tolerance Test (OGTT) as a Useful Tool for Early Diagnosis of Type 2 Diabetes Mellitus and Prediction of Metabolic Risks in Children and Adolescents

Kostopoulou Eirini , Tikka Maria , Rojas Gil Andrea Paola , Partsalaki Ioanna , Spiliotis Bessie

Objective: Type 2 Diabetes Mellitus(T2DM)and obesity represent two major health hazards in children and adolescents, with rising prevalence. Several markers have been developed in order to diagnose T2DM and detect potential metabolic abnormalities.The objective of the study was to examine glucose tolerance in Greek children and adolescents and the differences in the glucose, insulin and c-peptide response curves between male and female children and adolescents...

hrp0092p3-49 | Diabetes and Insulin | ESPE2019

Significance of the Early Marker of Nephrine Diabetic Nephropathy of the Uzbek Nationality with the First Type of Diabetes Mellitus

Rakhimberdiyeva Ziyoda , Shagazatova Barno , Alimova Nasiba

Goal of Research: to assess the significance of the early marker of nephrine diabetic nephropathy of the Uzbek patients with the First Type of diabetes mellitus.Materials and Methods: 100 patients with DM 1 were examined, including 80 patients with normoalbuminuria (NAU) and 20 patients at the microalbuminuria (MAU). The patients were from 1 to 14 years old with the disease duration from 1 to 5 years. They included 48 bo...

hrp0092p3-50 | Diabetes and Insulin | ESPE2019

Hybrid Diabetes with Good Response to Metformin in an Adolescent with Polyglandular Polyendocrinopathy (APS2)

Hamed Noor , Soliman Ashraf

Introduction: Development of type 1 diabetes is well known in cases of type 2 autoimmune polyglandular syndrome (APS). We describe a case of APS2 who developed a hybrid form of diabetes that responded to metformin therapy.Case: The patient is a 17.5 year old male patient who has been diagnosed with APS2 at the age of 13 years with primary adrenal insufficiency and autoimmune hypothyroidism .he has been on treatment with ...

hrp0092p3-52 | Diabetes and Insulin | ESPE2019

Off Label use of CGM in a Pediatric Patient with Type 1 Diabetes Mellitus Under the Age of 2

Burdea Liliana , Robinson Sylvia , Mantis Stelios

Introduction: Continuous Glucose Monitoring (CGM) is an asset for patients with type 1 DM. The Dexcom G6 is FDA approved for use in patients 24 months and older. This CGM does not require any calibrations or point of care interventions and lasts up to 10 days when inserted into the subcutaneous tissue. We present a case of a 17 month-old patient started on CGM (Dexcom G6), with subsequent improvement in glucose variability and continued excellent glycemic cont...

hrp0092p3-53 | Diabetes and Insulin | ESPE2019

A Case of Congenital Hyperinsulinism due to ABCC8 Mutation: A Challenge to Diagnosis, Management, and Treatment

Karabouta Zacharoula , Rouga Elena , Nakouti Eleni , Bisbinas Vasiliki , Giannopoulos Andreas

Introduction: Congenital hyperinsulinism(CHI) is a rare complex disorder of hypoglycaemia attributable to inappropriate and dysregulated insulin secretion from the pancreas with an incidence of 1:50 000(1:2500 in consanguineous populations). Genetics involves defects mainly in the KATP channel genes ABCC8 and KCNJ11.Aim: We describe a male infant, presented with refractory hypoglycaemia the first week of life.<p clas...

hrp0092p3-54 | Diabetes and Insulin | ESPE2019

Relationship Between Chloride Infusion and Base Excess in Initial Treatment of Pediatric Diabetic Ketoacidosis

Sawano Kentaro , Nagamatsu Fusa , Shimura Kazuhiro , Abe Yuki , Izumita Yukie , Ogawa Yohei , Komatsu Nagisa , Takishima Shigeru , Nakamura Akie , Nyuzuki Hiromi , Yamaguchi Takeshi , Muroya Koji , Watanabe-Yamamoto Sayaka , Nagasaki Keisuke , Saitoh Akihiko , Hasegawa Yukihiro

Background: In initial treatment of DKA, volume expansion should begin with 0.9% saline to restore the peripheral circulation. The use of large amounts of chloride-rich/bicarbonate-free fluids may cause the rapid development of hyperchloremic metabolic acidosis, which is described in ISPAD Clinical Practice Consensus Guidelines 2018.The severity of DKA, defined by pH, HCO3- Base Excess (BE), is one of the factor...

hrp0092p3-55 | Diabetes and Insulin | ESPE2019

The Role of Patient Adherence to Insulin Pump Therapy with Long-Term Treatment of Type 1 Diabetes

Turkunova Mariia , Bashnina Elena , Tsargasova Irina , Klitsenko Olga , Berseneva Olga

Background: Insulin pumps are widely used in the treatment of type 1 diabetes mellitus (T1D) in children because of numbers of advantages in compare with multiple daily insulin injections (MDI). However, the long-term efficacy of continuous subcutaneous insulin infusion therapy (CSII) in achieving and maintaining of diabet stability is still not resolved.Purpose: Determine the feffectiveness-related factors of glycemic c...

hrp0092p3-56 | Diabetes and Insulin | ESPE2019

Long-Term Honeymoon Period in Type 1 Diabetes: True Diagnosis MODY5; New Mutation of HNF1B

Bideci Aysun , Küpçü Zekiye , Döğer Esra , Çamurdan Orhun , Cinaz Peyami

Introduction: MODY is an autosomal dominant inherited type of diabetes that has been diagnosed before the age of 25 and caused by pancreatic β-cell dysfunction. HNF1B-MODY is more rare than other MODY causes and its frequency is between 1-5%. Mutations in HNF1B (MODY 5) are associated with pancreatic agenesis, kidney anomalies, genital system malformations and liver dysfunction.Case: The patient is 8 years 2 ...

hrp0092p3-57 | Diabetes and Insulin | ESPE2019

Prevalence of Celiac Disease (CD) and Autoimmune Thyroid Dysfunction (AITD) in Indian Children with Type 1 Diabetes

Chugh Vasundhara , Arya Archana , De Hriday

Objective: To estimate the prevalence of Celiac disease (CD) and autoimmune thyroid dysfunction (AITD) in children with Type 1 Diabetes.Study Design: The analysis included 177 (83 girls, 94 boys) children and adolescents with a diagnosis of Type 1 Diabetes who were followed up for a duration of more than 2years at Sir Ganga Ram Hospital, a tertiary care hospital in Northern India.Results</s...

hrp0092p3-58 | Diabetes and Insulin | ESPE2019

Mauriac's Syndrome: A Complication of Poorly Controlled Type 1 Diabetes Mellitus in Childhood and Adolescence

Osokina Irina

Background: Mauriac's syndrome (MS) may occur in patients with poor controlled type 1 diabetes mellitus (DM1), with often ketoacidosis, episodes of hyperglycemia and hypoglycemia, under the dose insulin. MS characterized growth retardation and puberty delay, Cushingoid obesity, moon facies, protuberant abdomen, hepatomegaly with transaminase elevation, dyslipidemia. Now it is a rare syndrome, firstly described by Mauriac in 1930.<str...

hrp0092p3-60 | Diabetes and Insulin | ESPE2019

Clinical Characteristics and Literature Review of Special Type of Diabetes Mellitus- Thiamine-Responsive Megaloblastic Anemia Syndromein Infant with Acute Ischemic Stroke

Gu Yi , Gong Chunxiu , Liang Xuejun

Background: Thiamine-responsive megaloblastic anemia syndrome(TRMA) is a rare disease characterized by diabetes mellitus, megaloblastic anemia and sensorineural hearing loss. The disease can be accompanied by attack of stroke, which are rarely reported. To analyze the clinical characteristics of a case of thiamine-responsive megaloblastic anemia with attack of stroke in our hospital and review the related literature of this syndrome in order to improve the dia...

hrp0092p3-61 | Diabetes and Insulin | ESPE2019

The Effect of Fibroblast Growth Factor 23 on Serum Phosphorus Level in Children with Diabetic Ketoacidosis

Doneray Hakan , Ozay Mustafa , Ozden Ayse , Ozturk Nurinnisa , Orbak Zerrin

Aim: The pathophysiology of developing hypophosphatemia in children with diabetic ketoacidosis (DKA) has not been sufficiently elucidated. Fibroblast Growth Factor 23 (FGF23) is a hormone that causes phosphate excretion from the kidneys. The increase of FGF23 in children with DKA may explain the pathophysiology of hypophosphatemia in these children. The aim of our study was to investigate the effect of serum FGF23 on serum phosphorus level in children with DKA...

hrp0092p3-62 | Diabetes and Insulin | ESPE2019

What Does the Insulin Pump Change in Children with Type 1 Diabetes? One-Year Clinical Follow-Up

Nezir Engin Muhammet Mesut , Arslanoglu Ilknur , Cangur Sengul

Aim: The insulin pump has an important contribution to quality of life and individualized insulin therapy. However, studies that observe clinical criteria can sometimes only reveal marginal benefits or minor differences. The use of insulin pump in our country has become recently widespread. Therefore, we aimed to share our clinical experience and to examine the effect of the pump on individual cases.Method: The records o...

hrp0092p3-63 | Diabetes and Insulin | ESPE2019

Severe Heart Disease can Cause Diabetes Mellitus Even in Younger Age: Case Reports of Two Japanese Adolescent Boys

Izumita Yukie , Abe Yuki , Tsukano Shinya

It is noted that patients with heart disease (HD) are likely to develop abnormal glucose metabolism and this metabolic deterioration usually occurs after middle age. However, we recently had two patients with congenital HD, who developed type 2 diabetes mellitus (DM) in their adolescence.The first patient underwent Fontan operation at 2 years of age for single ventricle and pulmonary atresia. His paternal grandfather had type 2 DM. He noticed polydipsia and polyuria at 15 year...

hrp0092p3-64 | Diabetes and Insulin | ESPE2019

De Novo Mutation of ABCC8 Gene in a Child with MODY Developed at 25 Months of Age

Lyeon Kim Goo , Heon Kwak Soo , Yu Jeesuk

Introduction: Recently the incidence of type 2 diabetes was explosively increased in children and adolescents. The underlying mechanism of childhood-onset type 2 diabetes mellitus may be different to the adult-onset type 2 diabetes. Therefore, it is useful to conduct genetic study in children with type 2 feature to understand underlying cause of glycemic dysregulation as well as for the management of diabetes mellitus.Case</stron...

hrp0092p3-65 | Diabetes and Insulin | ESPE2019

Insulin-Induced Oedema in a Child with Newly Diagnosed Diabetes Mellitus

Cakir Meltem Didem , Baysal Ozlem

Oedema is a care complication of insulin therapy. It affects mainly patients with newly diagnosed type 1 diabetes mellitus, poorly controlled diabetes mellitus or patients on large doses of insulin. There are only a few case report showing that it is an uncommon and probably an under-reported complication. Two mecanisms are known: the sodium and water retention and vasoactive mediators release. The oedema tends to develop shortly after initiation of insulin therapy and resolve...

hrp0092p3-66 | Diabetes and Insulin | ESPE2019

Familial Hypercholesterolaemia as a Cause of Dyslipidemia in Patient with Type 1 Diabetes

Brandt-Varma Agnieszka , Hennig Matylda , Mysliwiec Malgorzata

Introduction: Diabetes type 1 (DM1) in children can result in lipid disorders due to insulin deficiency. Familial hypercholesterolaemia (FH) is a very common monogenic disorder with occurrence of 1:250 and it may lead to development of cardiovascular disease (CAD) in a very young age.Case report: Female patient with diabetes diagnosed at the age of 5, was referred to joint diabetes and lipid clinic due to high levels of ...

hrp0092p3-67 | Diabetes and Insulin | ESPE2019

What has Changed in Type 1 Diabetes Mellitus Cases in the Last Eight Years? A Single Center Experience

Çiçek Dilek , Tatli Zeynep Uzan , Direk Gül , Akin Leyla , Hatipoglu Nihal , Kendirci Mustafa , Kurtoglu Selim

Objectives: Type 1 diabetes mellitus (DM) is an autoimmune disease caused by the destruction of pancreatic beta cells. The frequency of Type 1 DM is increasing, and the highest incidence rate is in children under 5 years of age. It is estimated that children under the age of five will develop approximately 70% of the cases under the age of 15, with an increased incidence.In our study, we aimed to evaluate the demographic, clinical an...

hrp0092p3-68 | Diabetes and Insulin | ESPE2019

Seasonal Variation and Epidemiological Parameters in Children from Western Greece with Type 1 Diabetes Mellitus (T1DM)

Kostopoulou Eirini , Papachatzi Eleni , Skiadopoulos Spyros , Rojas-Gil Andrea-Paola , Spiliotis Bessie

Introduction: A positive correlation between the onset of T1DM and winter has been suggested by studies conducted in different countries.Objective: To investigate the seasonal variation of T1DM diagnosis and additional epidemiological parameters in children from Western Greece diagnosed with T1DM.Methods: 105 patients, 44 males and 61 females, aged 1 to 16 years (mean: 8.2±4 y...

hrp0092p3-69 | Diabetes and Insulin | ESPE2019

An 8-Year-Old Boy with Down Syndrome who has had a History of Transient Hyperinsulinemia and was found to have Type 1 Diabetes During ALL Treatment

Nishimura Naoko , Iwanaga Kogoro , Kawai Masahiko

Case: An 8-year-old boy with Down syndrome. He was born at 36 week of gestation, birth weight was 1668 g (-2.5 SD). He complicated transient hyperinsulinemia (THI) treated with diazoxide for 2 months and hypothyroidism continuing treatment with levothyroxine. He was not detected transient abnormal myelopoiesis at neonatal period. He was diagnosed with precursor B-cell acute lymphoblastic leukemia (ALL) at age 8 years and started chemotherapy with a steroid, an...

hrp0092p3-70 | Diabetes and Insulin | ESPE2019

Indicators of Caries Risk in Children with Type 1 Diabetes Mellitus

M El-Tekeya , M El Tantawi , H Fetouh , Mowafy Ehsan , Khedr N Abo

Purpose: was to evaluate the interaction of caries risk indicators and metabolic control in children with type 1 diabetes mellitus.Methods: The study included 50 children with type 1 DM and 50 healthy controls. Diabetic children were classified into 3 groups: well, fairly, and poorly controlled based on glycosylated hemoglobin level. Personal, family data, medical and dental history were collected. Children were examined...

hrp0092p3-71 | Diabetes and Insulin | ESPE2019

Vitamin D Status in Egyptian Children with Newly-Diagnosed Type 1 Diabetes and its Relation to Autoimmune Destruction of Pancreatic Beta Cells

Laimon Wafaa

Background: The relationship between 25 hydroxy cholecalciferol (25OHD) deficiency and autoimmune diseases including type I diabetes (T1D) is an ongoing area of research interest. Furthermore, vitamin D seems to affect β cells through calcium regulation, as insulin release is a calcium-dependent process. The aim of the study was to screen for (25OHD) deficiency in children with clinical onset of T1D and study the correlation between its serum levels an...

hrp0092p3-72 | Diabetes and Insulin | ESPE2019

Hematologic Indices Indicating Platelets Activity in Children with Type 1 Diabetes

Dalili Setila , Baghersalimi Adel , Koohmanaee Shahin , Hassanzadeh Rad Afagh , Farzamfard Venus

Aim: The aim of this study was to evaluate hematological indices especially PLT indices in children with T1DMMaterials and Methods: in this case-control study which was conducted on 166 participants including 83 children with diabetes type 1 and 83 children hospitalized for thorough assessment of short stature, PLT count, MPV, PDW, WBC count, hemoglobin, blood sugar,PCT, P-LCR, ans PLR were assessed. Patients with type 1...

hrp0092p3-73 | Diabetes and Insulin | ESPE2019

The Prevalence of Hypertension and its Relationship to Glycemic Control in Children with Type 1 Diabetes Mellitus

Khater Doaa , Omar Magdy , Abozaid Heba

Background: Type 1 diabetes (T1DM) is a chronic disease with many chronic complications as nephropathy, retinopathy and neuropathy or macrovascular complications as coronary artery disease and peripheral vascular disease due to the effects of hyperglycemia and dyslipidemia on vascular endothelial function. Moreover, in patients with T1DM, hypertension (HTN) is a significant contributor to the development of both micro- and macrovascular complications.<p cl...

hrp0092p3-74 | Diabetes and Insulin | ESPE2019

Does Metformin Therapy Prolong the Honeymoon Period in Obese Adolescent with Hybrid Diabetes?

Hamed Noor , Elawwa Ahmed , Soliman Ashraf

Introduction: Hybrid diabetes is a challenging form od diabetes that need to be more studied. We describe a case of hybrid diabetes with a prolonged honeymoon due to the use of metformin.Case: Our patient is a 10 year old female patient who was diagnosed as type 2 DM on September 2017 at the age of 8 years. She was obese with BMI = 29.8 Kg/ m^2 with marked acanthosis nigricans. She had a patch of vitiligo on the face...

hrp0092p3-75 | Diabetes and Insulin | ESPE2019

A 16-Year-Old Girl with Prader-Willi Syndrome and Type 2 Diabetes Mellitus

Osokina Irina

Background: Prader-Willi syndrome (PWS) is a complex genetic disorder with implications on the endocrine and neurologic systems, metabolism, and behavior. Early in life, PWS is characterized by hypotonia and failure to thrive, followed by obesity and hyperphagia. Patients with PWS develop hypothalamic dysfunction which may lead growth hormone deficiency, hypogonadism, hypothyroidism, adrenal insufficiency and poor bone mineral density. Traditionally, obesity i...

hrp0092p3-76 | Diabetes and Insulin | ESPE2019

Extra Attention to be Paid When Looking After Boys with Type 1 Diabetes Mellitus in Oman

Alsaffar Hussain , Alrawahi Athila , Alhubaishi Zumaima , Alshukaili Maha , Ullah Irfan , Alhinai Shaima , Alshidhani Azza , Alyaarubi Saif

Introduction: More than 1,106,500 worldwide children were living with type1 diabetes mellitus (T1DM) in 20171. Researchers concluded that better glycaemic control is associating with lesser complications of this chronic condition. Target HbA1c is recommended to be <48mmol/mol(<6.5%) and <53mmol/mol(<7%) as per NICE and ISPAD respectively2. The glycaemic control represented by HbA1c was worse amongst the British gir...

hrp0092p3-77 | Diabetes and Insulin | ESPE2019

Factors Affecting the Preservation of C-Peptide Secretion in Egyptian Children with Type 1 Diabetes

El-hawary Amany , Aboelenin Hadil , El-Helaly Rania , El-Gwad Ahmed Abd

Background: type I diabetes is associated with progressive destruction of pancreatic β-cells with gradual decline of insulin secretion. C-peptide is considered the best indicator of endogenous insulin secretion in patients with diabetes.Aim of the Work: evaluate the effect of different variables associated with preserved pancreatic beta cell function at one year after diagnosis of children with type I DM.<p c...

hrp0092p3-78 | Diabetes and Insulin | ESPE2019

Prevalence of Fatty Liver in Children with Type 1 Diabetes Mellitus Attending Diabetes Clinic of Alexandria University Children's Hospital

Mowafy Ehsan , Mahfouz Amel , El Neily Dalia , Ramzy Heba

Background: The non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. It is not uncommon in children with type 1 Diabetes Mellitus. It is often asymptomatic and discovered accidentally.Aim: The aim of this work was to screen the presence of fatty liver among children with type 1 DM attending the diabetes Clinic of Alexandria University Children's Hospital and its relation to the state ...

hrp0092p3-79 | Diabetes and Insulin | ESPE2019

Hyperinsulinemia as A Consistent Feature in The Extremely Rare Donohue Syndrome

Khalaf Amira Nabil

Donohue syndrome (also known as leprechaunism) is an extremely rare and severe autosomal recessive genetic disorder. Leprechaunism derives its name from the fact that people with the disease often have elfin features and are smaller than usual. Leprechaunism is also characterized by abnormalities of the endocrine system ; such abnormalities include hyperinsulinemia. Due to the mutation in Insulin receptor gene, infants with leprechaunism fail to use insulin effectively (insuli...

hrp0092p3-80 | Diabetes and Insulin | ESPE2019

A Real-Life Experience with a New Insulin Co-Formulation Degludec/Aspart for one Year in Poorly Controlled Children and Adolescents with Type 1 Diabetes

kirkgoz tarik , Eltan Mehmet , Betul Kaygusuz Sare , yavas abali Zehra , Guran Tulay , Bereket Abdullah , Turan Serap

Achieving optimal metabolic control can be extremely challenging in some children and adolescents with T1DM. The adherence to multiple injections/day is among the leading causes of suboptimal control. Recently insulin degludec/aspart co-formulation (70%IDeg+30%IAsp: IDegAsp) has become available. Because of the longer-duration of IDeg, and retained individual pharmacokinetics of IDeg and IAsp, we wanted to test insulin IDegAsp's efficacy in our patients with po...

hrp0092p3-81 | Diabetes and Insulin | ESPE2019

Cerebellum Malacia Lesions as a Result of Severe Diabetic Ketoacidosis in 12 Month Old Patient

Brandt-Varma Agnieszka , Szmigiero-Kawko Malgorzata , Mysliwiec Malgorzata

Introduction: Diabetic ketoacidosis (DKA) in children is related with high risk of severe complications in the central nervous system such as cerebral oedema, hematoma and thrombosis.The occurrence of cerebral oedema in children with DKA is around 1: 100 and is higher in young children with severe acidosis and in whom DKA is the first manifestation of the disease.Case Report: 12-month-old patient d...

hrp0092p3-82 | Diabetes and Insulin | ESPE2019

Assessment of Testicular Volume by Ultrasound in Children and Adolescents with Type 1 Diabetes

Lohiya Nikhil , Khadilkar Vaman , Khadilkar Anuradha , Kinare Arun

Introduction: Poorly controlled type 1 diabetes affects the hypothalamic pituitary axis and is likely to have a negative impact on spermatogenesis and result in infertility. Further, a chronic complication of diabetes may also be angiopathy of testicular vessels. Thus, at our center for children with diabetes, testicular ultrasound evaluation is performed on adolescent boys with duration of diabetes> 2 years.Objective</strong...

hrp0092p3-83 | Diabetes and Insulin | ESPE2019

Diabetes Mellitus in a 16-Year-Old Boy Developing Multiple Neuro-Endocrine Dysfunctions in the Course: Is it Type 1 Diabetes or Wolfram Syndrome, or Both?

Santi Maristella , Emma Flück Christa , Böttcher Claudia

Introduction: Autosomal recessive mutations in the Wolfram syndrome type 1 gene are responsible for the classical Wolfram syndrome (OMIM_ 222300), also known by the acronym "DIDMOAD" (diabetes insipidus, diabetes mellitus (DM), optic atrophy and deafness). The gene encodes wolframin, a membrane glycoprotein, which helps to regulate the calcium homeostasis in the endoplasmic reticulum of many different tissues, including the pancreatic...

hrp0092p3-84 | Diabetes and Insulin | ESPE2019

A Low-Carbohydrate Diet Improves Metabolic Control in a Type 1 Diabetic Child Without Side Effects

Klee Philippe , Stasinaki Aikaterini , Gozzi Tiziana , Schwitzgebel Valérie

Background and Aims: Despite intensive insulin treatment of type 1 diabetes (T1DM), metabolic control remains suboptimal, especially in children. In an attempt to optimize postprandial glycaemia, some families decrease the amount of carbohydrates contained in a meal. While "low-carbohydrate diets" may improve metabolic control in some selected populations, controversies remain around the risk of hypoglycemia and ketoacidosis and the impact of such diet...

hrp0092p3-85 | Diabetes and Insulin | ESPE2019

To Find Prevalence of Type 1 with Autoimmune Thyroid Disorders, Age, Duration, Thyroid Antibodies, Growth and Glycemic Variability in Indian Scenario

Raj Viralsinh

Objective: To Find Prevalence of Type 1 with Autoimmune Thyroid Disorders, Age, Duration,Thyroid Antibodies, Growth and Glycemic variability in Indian Scenario.Methods and Plan: This is retrospective observational Multicentric Study carried out in our four (4) centers of DIA CARE, Ahmedabad during January to December 2018, We divided Diabetes Type 1 Patient with Autoimmune Thyroid disorder According to Age, Diabetes Dura...

hrp0092p3-86 | Diabetes and Insulin | ESPE2019

Clinical Profile of Paediatric Patients with type 1 Diabetes Mellitus at a Tertiary Health Care Center in the Oriental Region of Northeastern Morocco

Ben Yakhlef Salma , Derkaoui Nada , Rouf Siham , Ezzerrouqi Amine , Latrech Hanane

Introduction: The growing pandemic of type 1 diabetes is considered as an enormous multifactorial public health challenge in the world. Many targeted interventions should be provided to improve type 1 diabetes management especially during childhood and adolescence.The purpose of this study is to elucidate the epidemiological, clinical and management profile of type 1 diabetes in Moroccan children and adolescents followed up in t...

hrp0092p3-87 | Diabetes and Insulin | ESPE2019

Comprehensive Analysis of HLA System Class II DRB1 in Children with Insulin Dependent Diabetes Mellitus in the North Azerbaijan and Iranian Azerbaijan

Ahmadov Gunduz , Noble Janelle , Ogle Graham

Keywords: Human Leukocyte Antigen system, DRB1 allelesDiabetes mellitus is one of the diseases, the genetics of which has been most widely studied. In 40-50 % cases it is connected with Human Leukocyte Antigene system. The major genetic deterninants of this disease are DQ and DR genes "DR3" and "DR4" haplotypes create high risk for diabetes.Insulin dependent diabetes mellitus risk is very high a...

hrp0092p3-88 | Diabetes and Insulin | ESPE2019

A Case of Type 2 Diabetic Adolescent With Sleep Apnea who was Successfully Stopped Metformin After Adenotonsillectomy

Hong Sung-Won , Ahn Young-Min , Seo Ji-Young

Sleep deficit is the well known risk factor for obesity in children and adult. Adenotonsillar hypertrophy is the main cause of obstructive sleep apnea(OSA) in childhood. Adult type (type II ) OSA is increasing in obese children. Eleven year old boy visited our clinic with chief complain of polyuria, polydipsia onset two weeks ago. His grandmother and father are type 2 diabetes mellitus. Adenotonsillectomy was recommended for tonsillar hyperthrophy (Grade 3) and had snoring for...

hrp0092p3-89 | Diabetes and Insulin | ESPE2019

A Mitophagic Response to iron Overload-Induced Oxidative Damage Associated with the PINK1/Parkin Pathway in Pancreatic Beta Cells

ZHANG Lina , LIANG Liyang , LIU Zulin , HOU Lele , OU Hui , HUANG Siqi

An increased iron overload led to a disorder in glucose metabolism. However, the mechanism through which iron overload induces beta cell death remains unknown. The present study revealed that ferric ammonium citrate treatment inhibited cell viability in vitro, induced a decline in mitochondrial membrane potential, increased oxidative stress and activated mitophagy. These effects could be alleviated by a reactive oxygen species scavenger. In summary, we demonstrated th...

hrp0092p3-90 | Diabetes and Insulin | ESPE2019

A Management Challenge of Acute Viral Hepatitis A in a Child Presented with DKA as a First Presentation

Fawzy Dina , elgebaly asmaa

Background: Diabetic patients frequently develop a constellation of electrolyte disorders. These patients are often potassium-, magnesium- and phosphate-depleted, especially in the context of diabetic ketoacidosis.Patients with type-1 diabetes are predisposed to develop a spectrum of liver diseases, which includes fatty liver, steatohepatitis and cirrhosis. The association of hepatitis A infection with type-1 diabetes is extremely rare.<...

hrp0092p3-91 | Diabetes and Insulin | ESPE2019

Association of Type 1 Diabetes and Celiac Disease In Child

Lassoued Najoua , Wannes Salmane , Hammouda Hachmi Ben , Soua Habib , Mahjoub Bahri

Introduction: The association between type 1 diabetes (T1D) and celiac disease (CD) has been described by many authors in both children and adults. The link between these two pathologies was identified more than 30 years ago, especially by pediatricians. The aim of this work was to study the clinical, biological, and evolutionary features of CD in diabetic children compared to a control group of non-celiac diabetic children.Patie...

hrp0092p3-92 | Diabetes and Insulin | ESPE2019

Case of Family Neonatal Diabetes with KCNJ11 Gene Mutation: Dynamics Monitoring

Chumak Svitlana

Background: The most common cause of permanent neonatal diabetes (PNDM) is heterozygous activating mutations in the KCNJ11 gene encoding the pore-forming Kir6.2 subunit of the pancreatic beta cell KATP channel.Objective and Hypotheses: To determine the dynamic of carbohydrate metabolism in family transferred from insulin to sulphonylureas (SU).Method: We studied a family (...

hrp0092p3-93 | Diabetes and Insulin | ESPE2019

Severe and Inaugural Diabetic Ketoacidosis in Children: Experience of a Pediatric Tunisian Department

guedria asma , Hadrich Zouhour

Introduction: Ketoacidosis is often indicative of diabetes in children in our Tunisian context. It can be severe and life-threatening, with mortality in the order of 1 to 2%.Methods: We report the results of a retrospective study over a period of 2 years (from 1/01/2017 to 31/12/2018) on all cases of inaugural ketoacidosis of type 1 diabetes mellitus in children, collected at the pediatric department of Mohamed Tlatl...

hrp0092p3-94 | Diabetes and Insulin | ESPE2019

Role of Renal Scintigraphy as an Early Predictor of Chronic Renal Damage in Children and Adolescents with Type1 Diabetes

Wahab Amina Abdel , Mohamed Yasmine , El Sharkawy Sonia , Hassaneen Ehab , Ahmed Ahmed

Background: Chronic kidney disease (CKD) was defined by structural or functional renal abnormalities, or an estimated glomerular filtration rate (GFR) of less than 60 mL/min per 1.73 m2. A child with CKD may develop many complications such as: anemia, poor growth and nutrition, bone and mineral disorders, cardiovascular complications, and complications of hemodialysis, and peritoneal dialysis.Aim: Assessment of severity ...

hrp0092p3-95 | Diabetes and Insulin | ESPE2019

Changes in the Microbiome of Pre-Type 1 Diabetic Children

Zhelyazkova Nikolina , Koleva Reni

Introduction: Type 1 Diabetes (T1D) is an autoimmune disease where β-cells of the pancreatic islets are destroyed. The vast majority of T1D cases are not due to genetic predisposition, implying that the prevalence is associated with environmental, nongenetic factors. One such factor is the microbiome and its correlation with T1D has been investigated in a multitude of studies.Aims: To investigate whether the curr...