Volume 82 | ESPE2014 | Next issue

ESPE 2014

Dublin, Ireland
18 Sep 2014 - 20 Sep 2014

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Dublin, Ireland; 18-20 September 2014. Further information

Free Communications

Fat Metabolism

hrp0082fc8.1 | Fat Metabolism | ESPE2014

Activation of the ER Stress Response in Cultured Human Umbilical Vein Endothelial Cells by Plasma Obtained from Prepubertal Obese Children

de Giorgis Tommaso , Di Silvestre Sara , Mohn Angelika , Di Pietro Natalia , Marcovecchio Maria Loredana , Cordone Vincenzo , Mandatori Domitilla , Chiavaroli Valentina , Bologna Giuseppina , Pandolfi Assunta , Chiarelli Francesco

Background: Childhood obesity is commonly associated with signs of endothelial dysfunction, characterized by impairment of insulin signaling and vascular NO availability. Recently both these features have been associated with endoplasmic reticulum (ER) stress, however the role of ER stress in the mechanism/s leading to vascular dysfunction in childhood obesity remains still to be established.Objective and Hypotheses: To evaluate ER stress and insulin-sti...

hrp0082fc8.2 | Fat Metabolism | ESPE2014

MicroRNA-152 Promotes Hepatic Steatosis by Suppressing the Wnt Signaling Pathway

Xu Xiao-qin , Li Guo-hua , Ji Chen-bo , Guo Xi-rong , Fu Jun-fen

Background: Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease in both children and adults; however, the exact pathogenesis of NAFLD remains obscure. Accumulating evidence supports the effects of miRNA in the lipid metabolism and the regulation of insulin resistance, providing a potential linkage between the miRNA and NAFLD.Objective and Hypotheses: The aims of this study were to explore microRNA (miRNA) expression profiles in NA...

hrp0082fc8.3 | Fat Metabolism | ESPE2014

Identification of Death Ligand TNF-Related Apoptosis-Inducing Ligand as a Potent Mitogen in Human Preadipocytes

Funcke Jan-Bernd , Zoller Verena , El Hay Muad Abd , Debatin Klaus-Michael , Wabitsch Martin , Fischer-Posovszky Pamela

Background: Adipose tissue is an important endocrine organ. Its secretion profile is robustly changed in the context of obesity fueling the development of comorbidities such as insulin resistance, diabetes mellitus type 2, and atherosclerosis. We have recently shown that the adipose tissue expression of the death ligand TNF-Related Apoptosis-Inducing Ligand TRAIL and its receptors is upregulated in obesity.Objective and Hypotheses: In this project, we in...

hrp0082fc8.4 | Fat Metabolism | ESPE2014

CREB-Regulated Transcription Coactivator 3: a New Adipokine Related to Childhood Obesity

Prats-Puig Anna , Soriano-Rodriguez Pilar , Oliveras Gloria , Blancafort Adriana , Diaz-Roldan Ferran , Carreras-Badosa Gemma , de Zegher Francis , Ibanez Lourdes , Bassols Judit , Puig Teresa , Lopez-Bermejo Abel

Background: CREB-regulated transcription coactivator 3 (CRTC3) is found in adipocytes where it may promote obesity through disruption of catecholamine signaling. CRTC3 knockout mice are resistant to diet-induced obesity.Objective and Hypotheses: The goals of the present study were i) to assess whether CRTC3 is a soluble protein secreted by adipose tissue ii) to explore whether CRTC3 is detectable and quantifiable in the circulation, and iii) to ...

hrp0082fc8.5 | Fat Metabolism | ESPE2014

Putative Gain-of-Function in Rats Carrying the Ghsr Q343X Mutation

Zizzari Philippe , Chebani Yacine , Chettab Khadidja , Pastor Marie , Korostelev Marie , Epelbaum Jacques , Tolle Virginie , Pantel Jacques

Background: The deciphering of the physiological importance of the GH secretagogue receptor (Ghsr), a G protein-coupled receptor (GPCR) depicted as the sole receptor of the pleiotropic hormone ghrelin, was initially compromised by the modest phenotype observed in Ghsr−/− animals. This lack of a robust response to total loss of Ghsr may result from developmental compensatory signals. Still, the description of rare mutations in the GHSR p...

hrp0082fc8.6 | Fat Metabolism | ESPE2014

A Novel Missense Variant in the Insulin Receptor Gene in Three Unrelated Irish Families with Severe Insulin Resistance Syndrome: Evidence for an Irish Founder Effect

Mavinkurve M , O'Connell S , Cody D , Isaac I , Harris J , Semple R K , Mc Donnell C

Background: Genetic defects in the insulin receptor (INSR) are rare. Precise prevalence is unknown and significant clinical heterogeneity exists. Over 120 allelic variants have been described to date, spread throughout the receptor, and few geographical founder effects have been described. In this case series we identify a novel missense mutation in the tyrosine kinase domain of the INSR in three independently ascertained Irish families.Objective and Hyp...