Volume 82 | ESPE2014 | Next issue

ESPE 2014

Dublin, Ireland
18 Sep 2014 - 20 Sep 2014

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Dublin, Ireland; 18-20 September 2014. Further information

Poster Category 3

Autoimmune Endocrine Disease

hrp0082p3-d3-646 | Autoimmune Endocrine Disease | ESPE2014

Hypothyroidism in Anorexia Nervosa due to Primary Autoimmune Pathogenesis

Chidanandaswamy Rajesh , Skae Mars

Background: Anorexia nervosa (AN) is associated with a number of endocrine abnormalities including a low serum free thyroxine level. Hypothyroidism in AN is a recognised condition which is associated with a low normal free thyroxine and triiodothyronine levels (FT4, FT3) with an elevated reverse T3 (rT3). Serum TSH levels are normal or slightly reduced, suggesting a hypothalamic origin to the suppressed thyroid function which is norm...

hrp0082p3-d3-647 | Autoimmune Endocrine Disease | ESPE2014

Autoimmune Disease and Arnold Chiari Syndrome: Any Correlation?

Ortolani Federica , Tummolo Albina , Fedele Stefania , Masciopinto Maristella , Pesce Sabino , Papadia Francesco , Cornacchia Domenica , Labbate Arianna , Vendemiale Marcella , Piccinno Elvira

Introduction: Type 1 Arnold Chiari syndrome (extension of cerebellar tonsils into the foramen magnum without involving the brain stem) causes ataxia, dysphagia, headache, breathing problems… So far, an association between Arnold Chiari and autoimmune diseases has not yet been described in literature.Case 1 description: M.V., on term third born, spontaneous delivery, non complicated pregnancy, normal physical and psychological development stages. He...

hrp0082p3-d3-648 | Autoimmune Endocrine Disease | ESPE2014

Genetically Proven APS Type 1 in Two Siblings

Yordanova Desislava , Stefanova Elisaveta , Kazakova Krasimira , Todorova Zdravka , Dimitrova Mihaela

Background: APS type 1 is characterized by an autosomal recessive inheritance. The clinical diagnosis is based on the presence of at least two of the three following diagnostic criteria: chronic mucocutaneous candidiasis, chronic hypoparathyroidism, and autoimmune adrenal insufficiency. Patients often develop other autoimmune diseases. APS type 1 is caused by mutations in the AIRE gene which encodes the AIRE protein. The protein probably acts as a transcription factor.<p c...

hrp0082p3-d3-649 | Autoimmune Endocrine Disease | ESPE2014

Rare Association of Diabetes Insipidus with Autoimmune Thyroiditis

Kocova Mirjana , Gjorceva Daniela Pop

Background: Diabetes insipidus of central origin has been described in association with other endocrine autoimmune diseases as a rare condition in adults. In children this association is extremely rare.Objective and hypotheses: To present a girl with a concurrent appearance of diabetes insipidus and autoimmune thyroiditis.Method: Diagnostic approach for both diseases.Results: A girl of 11 years presented with...

hrp0082p3-d3-650 | Autoimmune Endocrine Disease | ESPE2014

Coexistence of Unusual and Distinctive İnitial Clinical Manifestations of Systemic Lupus Erythematosus (SLE): a Child Case Presentation and Evaluation of Polyglandular Autoimmune Syndrome in SLE

Karaoglan Murat , Keskin Mehmet , Ozturk Sibel , Kesin Ozlem

Background: Involvement of multiple spesific endocrine organs in systemic lupus erythematosus (SLE), as initial manifestations, are quite rare. These manifestations can appear singly or combined. But they have been usually reported singly. We report a child case who coexists many of rare clinical features of SLE at the same time at onset.Objective and hypotheses: Polyglanduler autoimmune syndrome may be a part of SLE. Coexistence of many polyglanduler au...

hrp0082p3-d3-651 | Autoimmune Endocrine Disease | ESPE2014

Diabetes Mellitus after Hematopoietic Stem Cell Transplantation

Narvaez Barros Karla Maria , Martorell Ariadna Campos , Leon Maria Clemente , Alvarez Izaskun Elorza , Fernandez Diego Yeste , Lezcano Antonio Carrascosa

Background: Patients who have received an hematopoietic stem cell transplantation (HSCT) have more risk of endocrine complications (hypothyroidism, hypogonadism, and growth retardation) but the incidence of diabetes after HSCT is not as well known. The pathogenesis of the diabetes is not well established, and is believed to be multifactorial: chemotherapy, pancreatic irradiation, inflammatory cascade and cytokines, steroids and predisposing genetic factors.<p class="abstex...

hrp0082p3-d3-652 | Autoimmune Endocrine Disease | ESPE2014

Preservation of Ovarian Function in Young Females Cancer Survivors with Risk of Ovarian Failure

Chueca Maria , Berrade Sara , Miguel Isabel San , Oyarzabal Mirentxu , de Ilurdoz Maria Sagaseta , Dura Teodoro , Molina Javier

Background: Ovarian function in young females with cancer can be damaged due to chemo-radiotherapy. One option to preserve fertility in these patients is the cryopreservation of ovarian tissue, but this is still experimental.Objective and hypotheses: Evaluate our experience with cryopreservation (indications, complications, and reimplantation). Through surveys, understand patient perspectives.Method: A total of 63 women were diagno...

hrp0082p3-d3-653 | Autoimmune Endocrine Disease | ESPE2014

Late Endocrine Effects in Children and Adolescentes Submitted to Allogenic Bone Marrow Transplantation

Kuperman Hilton , Pinchiari Lilian Argentino , Medrado Caroline Kupsch , Battistin Claudilene , Manna Thais Della , Dichtchkenian Vae , de Menezes Filho Hamilton Cabral , Steinmetz Leandra , Cominato Louise , Fernandes Juliana Folloni , Cristofani Lilian Maria , Filho Vicente Odone , Damiani Durval

Background: Pediatric bone marrow transplantation (BMT) can lead to endocrine dysfunctions due to common pre-operative regimens involving chemo and radiotherapy.Objective and hypotheses: To evaluate the prevalence an time-of-onset of endocrine dysfunctions after BMT in children and adolescents.Method: A retrospective cohort-study design was performed. The inclusion criteria were: <18 years of age at the time of their allogenic ...

hrp0082p3-d3-654 | Autoimmune Endocrine Disease | ESPE2014

Adrenocortical Tumor: a Case Report

Guidoni Elisa , Scarinci Renato , Municchi Giovanna

Background: The annual worldwide incidence of childhood adrenocortical tumors (ACT) ranges from 0.3 to 0.38/million children below the age of 15 years. Only 1–2% of them are feminizing ACT occurring in prepubertal boys and presenting with gynecomastia that normalizes after tumor removal.Case report: We present a case of a feminizing ACT. The boy was referred for bilateral gynecomastia, appeared 6 months before, at the chronological age (CA) of 7.5 y...

hrp0082p3-d3-655 | Autoimmune Endocrine Disease | ESPE2014

A Conservative Approach to the Management of Endocrine Neoplasia in Carney Complex in an Adolescent Male

Frerichs Carley , Didi Mohammed , Abernethy Laurence , Kenny Simon , Ellis Ian , Blair Joanne

Background: Carney complex (CC) is a rare, dominantly inherited condition due to mutations of the tumour suppressor gene PRKAR1A. Endocrine manifestations include: Cushing’s syndrome (CS) due to primary pigmented nodular adrenocortical disease, pituitary adenomas, testicular neoplasms, thyroid tumours, and ovarian cysts. The management of some of these tumours is controversial.Objective and hypotheses: To describe conservative management of CC.<...

hrp0082p3-d3-656 | Autoimmune Endocrine Disease | ESPE2014

Two Cases of Thyroid Carcinoma in Children

Mitchell Bethany , Abid Noina , Eatock Fiona , Donnelly Deirdre

Background: Whilst thyroid carcinoma is rare in children, thyroid nodules in children have an increased risk of being malignant. Two 10-year-old patients with thyroid nodules presented to the Royal Belfast Hospital for Sick Children in December 2013.Objective and hypotheses: Illustration of sporadic and genetic presentations of thyroid carcinoma in children.Method: Presentation of two cases of thyroid carcinoma in children.<p c...

hrp0082p3-d3-657 | Autoimmune Endocrine Disease | ESPE2014

Is There Any Correlation Between Height and Pediatrics’ Malignancy

Darbandi Bahram , Jafroodi Maryam , Baghersalimi Adel , Koohmanaee Shahin , Hassanzadeh Rad Afagh , Dalili Setila

Background: Recent studies had been demonstrated that raised height could be related with Hodgkin lymphoma (HL). In addition, increased osteo–sarcorma had been indicated in taller individuals and those with earlier pubertal growth spurts. however, some investigators obtained no significant relation between elevated height and childhood malignancy.Objective and hypotheses: We aimed to investigate whether there is any correlation between height and pe...

hrp0082p3-d3-658 | Autoimmune Endocrine Disease | ESPE2014

Increasing Testicular Size due to Bilateral Large Cell Calcifying Sertoli Cell Tumours in a Peri-Pubertal Child with Carney Complex

Geoghegan Sarah , Morrissey Rose , Moore Michael , O'Sullivan M , Murphy Michelle , Irvine Alan , O'Riordan Stephen , Quinn Fergal , O'Connell Susan

Background: Carney complex (CNC) is a rare multi endocrine neoplasia syndrome associated with endocrine and non-endocrine tumours. Three types of testicular tumour have been described; large cell calcifying Sertoli tumours (LCCST), Leydig cell tumours and testicular tumours of adrenal origin. LCCST is a rare benign stromal tumour, which has been observed in 41% of males affected with CNC, usually appearing in the first decade of life. It can be hormonally active, presenting wi...

hrp0082p3-d3-659 | Autoimmune Endocrine Disease | ESPE2014

Evaluation of the Relation between Thyroid Dysfunction and Oxidant/Antioxidant Status in Obese Children

Asci Ali , Bulus Derya , Andiran Nesibe , Kocer-Gumusel Belma

Background: Obesity has been defined as ‘abnormal or excessive fat accumulation that may impair health’ by World Health Organization.Objective and hypotheses: Although the role of oxidative stress in obesity has been interest of subject in recent studies, comprehensive studies evaluating parameters of oxidant/antioxidant status in children are limited. Moreover, there has been an increasing focus on the relationship between obesity and thyroid ...