ESPE Abstracts

Objective and hypotheses: The work was initiated to comparatively assess degree of compensation and prevalence of complications of type 1 DM in children in Uzbekistan from 1998 to 2012 according to the screening data.

Method: 950 children (coverage of 80.3%) with type 1 DM were screened in 2012 within the WDF grant ‘Children’s Diabetes in Uzbekistan’, the degree of compensation and prevalence of type 1 DM chronic complications were compared with those obtained for 618 children (coverage of 98%) examined in 1998. Compensation level was estimated according to ISPAD criteria (2011).

Results: In 2012 target levels of therapy in children (HbA1c <7.5%) were reached in 24.3% comparing with 16% in 1998, mean level of HbA1c decreased from 12.7 to 9.6% (P<0.001). The comparative analysis showed significant decrease in prevalence of physical retardation by 3.45 times in children (P<0.0001) and decrease of sexual retardation by 3.4 times (P<0.0001). In children prevalence of diabetic complications reduced as follows, by 7.9 times for retinopathy (P<0.0001), by 1.6 times for neuropathy (P<0.0001), by four times for diabetic nephropathy with ESRD (P<0.0001), and by 2.3 times for diabetic hairopathy (P<0.001). Occurrence of cataract has the tendency to reduce.

Conclusion: The analysis of screening results showed efficiency of the National Register and a correct choice of strategy and tactics on optimization of quality of care for children with type 1 DM in Uzbekistan.