Volume 82 | ESPE2014 | Next issue

ESPE 2014

Dublin, Ireland
18 Sep 2014 - 20 Sep 2014

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Dublin, Ireland; 18-20 September 2014. Further information

Poster Category 3

Diabetes (4)

hrp0082p3-d3-748 | Diabetes (4) | ESPE2014

Monogenic Diabetes in a Paediatric Population: Finding the Needle in the Haystack

Mavinkurve M , Johnston N , Carroll A , Donnell C Mc , Byrne M M , Murphy N P

Background: Ireland has a high incidence of type 1 diabetes in childhood (16.8/100, 000 per year (1). A small percentage of children with diabetes have maturity onset diabetes of the young (MODY) (2). Establishing the correct diagnosis is critical to optimal therapy and future genetic counselling (3).Objective and hypothesis: To review the cohort of children attending our tertiary diabetes service and describe the clinical features of those where MODY wa...

hrp0082p3-d3-749 | Diabetes (4) | ESPE2014

Hyperglycemia: MODY: a Diagnosis to Remember

Monteiro Ricardo , Fitas Ana Laura , Amado Marta , Pina Rosa , Lopes Lurdes

Background: The detection of hyperglycemia on occasional evaluation raises the diagnosis of diabetes mellitus (DM). Maturity onset diabetes of the young (MODY), namely glucokinase deficiency, should be considered in cases of non-progressive hyperglycemia associated with a positive family history.Objective and hypotheses: We describe two unrelated cases of asymptomatic hyperglycemia where glucokinase mutations were detected.Method: ...

hrp0082p3-d3-750 | Diabetes (4) | ESPE2014

A Case of Type 1 Diabetes Associated with Cerebellar Ataxia: Stiff-Person Syndrome

Kurtoglu Selim , Okdemir Deniz , Hatipoglu Nihal , Akin Leyla , Gul Ulku , Canpolat Mehmet , Kendirci Mustafa

Background: Stiff-person syndrome (SPS) is a rare disorder which is characterized by muscle rigidity, spasm and cerebellar abnormalities. The etiology is not clarified yet. 80% of cases are caused by an autoantibody against GAD that inhibits synthesis of GABA. Other autoimmune diseases such as type 1 diabetes mellitus and thyroiditis are often associated.Aim: To underline the importance of considering SPS in differential diagnosis of patients with type 1...

hrp0082p3-d3-751 | Diabetes (4) | ESPE2014

Continuous Glucose Monitoring vs Oral Glucose Tolerance Test and HbA1C in the Evaluation of Glycemic Abnormalities in an Obese Adolescent Before vs After Partial Gastrectomy

Soliman Ashraf , Sabt Aml , Alyafei Fawzia , Eldarsy Nagwa

Background: We compared continuous glucose monitoring (CGMS) (Medtronic) to oral glucose tolerance test (OGTT) and HbA1c in the follow-up of glycemic abnormality in an adolescent girl with morbid obesity and glycemic abnormalities before and after 2 months of partial gastrectomy. This 16-year-old adolescent girl presented with obesity (weight 98 kg, height 158 cm, BMI=39.2 kg/m2), acanthosis nigricans and nocturnal polyuria and polydipsia. Trials to reduce weight th...

hrp0082p3-d3-752 | Diabetes (4) | ESPE2014

The Psychological Impact of Diabetes on Glycaemic Control in Affected Saudi Children at Different Developmental Age Groups

Babiker Amir , El Rashid Mona , Al Jurayyan Nasir , Druce Maralyn , Bahebri Aban , El Ahmedi Mohamed , Errasoul Ahmed H , Gasim Hala , Coppack Simon

Background: Diabetes is the third commonest chronic disease of childhood. When a child or an adolescent is diagnosed with type 1 diabetes (T1D), adaptation to a new life is usually a challenge for the whole family. There are specific challenges posed by T1D on the affected children, and their families, at different developmental age groups. The correlation between HbA1c and age specific psychological challenges, to our knowledge, has not been previously explored in the Middle ...

hrp0082p3-d3-753 | Diabetes (4) | ESPE2014

Type 1 Diabetes Mellitus in Pediatric Population: Chronic Complications and Associated Diseases

Andrade Joana , Gomes Clara , Luis Assuncao , Laranjo Gabriela , Campos Joana

Background: Type 1 diabetes mellitus (T1DM) is the second most frequent chronic disease in childhood and adolescence. Chronic hyperglycemia is responsible for numerous long term complications, not only microvascular (retinopathy, nephropathy and neuropathy), but also macrovascular (ischemic cardiopathy, cerebrovascular disease and peripheral vascular disease). On the other hand, the T1DM immune modification is responsible for an increased incidence of other autoimmune diseases...

hrp0082p3-d3-754 | Diabetes (4) | ESPE2014

Ketoacidosis-Associated Stroke: Cerebral Infarction

Orbak Zerrin , Doneray Hakan , Yesilcibik Seda , Kantarci Mecit , Tan Huseyin , Kucuk Nuran , Kosan Celalettin

Background: Type 1 diabetes mellitus (T1DM) is a common autoimmune condition in childhood and may be complicated by episodes of diabetic ketoacidosis (DKA). DKA is a state of severe insulin deficiency, resulting in hyperglycemia, ketonemia, acidemia, and systemic inflammation. This is predominantly attributable to intracerebral complications. We report a girl with a newly diagnosed T1DM who presented with DKA and cerebral infarction.Case: A 13-year-old p...

hrp0082p3-d3-755 | Diabetes (4) | ESPE2014

Multiple Daily Injections Since the Diagnosis of Type 1 Diabetes Mellitus in Children and Adolescents: Assessment of 3 Years

Cardoso Rita , Martins Dora , Batista Nanci , Aveiro Lina , Capitao Rita , Ribeiro Helena , Freitas Filomena , Simao Luisa , Dinis Isabel , Mirante Alice

Background: Functional insulin therapy allows precise insulin adjustments to achieve normoglycaemia.Objective and hypotheses: To assess metabolic control (A1c) and lipid profile in children and adolescents with DM1 in a 3-year period under multiple daily injections (MDI) since the diagnosis.Method: Retrospective analysis of children and adolescents under functional insulin therapy since the diagnosis of DM1. The variables studied w...

hrp0082p3-d3-756 | Diabetes (4) | ESPE2014

Haemolysis and Acute Pancreatitis During Diabetic Ketoacidosis Treatment in a 14-Year-Old Boy with Unknown Glucose-6-Phosphate Dehydrogenase Deficiency

Ortolani Federica , Tummolo Albina , Torelli Cataldo , Masciopinto Maristella , Fedele Stefania , Lanzillotto Maria Paola , Nicastro Francesco , Papadia Francesco , Vendemiale Marcella , Piccinno Elvira

Background: G6PD deficiency is conventionally affiliated with drug induced oxidative stress, but an association with diabetes mellitus is seldom reported. Hypertriglyceridemia from insulin deficiency can be the cause of severe pancreatitis complicating DKA in children.Case report: A 14-year-old Bulgarian boy, no significant past medical history, hospitalized in Pediatric Surgery Department for abdominal pain, hematemesis insorted during a cruise trip. Re...

hrp0082p3-d3-757 | Diabetes (4) | ESPE2014

Pneumothorax, Pneumomediastinum, and Subcutaneous Emphysema: Complications of Severe DKA in T2DM Obese Patient

Ortolani Federica , Tummolo Albina , Torelli Cataldo , Masciopinto Maristella , Fedele Stefania , Nicastro Francesco , Papadia Francesco , Vendemiale Marcella , Piccinno Elvira

Case presentation: G. 15 years 8 months; H 180 cm; P 149.6 kg, BMI 46 kg/m2, second born, father obese, healthy mother and two brothers, no familiarity for T1DM/T2DM, no gestational diabetes. Bronchial asthma, since 2-year-old important weight increase. Flue, polyuria, polydipsia, 12 kg loss in 15 days, anorexia since 5 days, vomit. Hospitalized for tachycardia, dyspnea, and asthenia. On arrival: serious dehydration, Kussmaul breathing, neck subcutaneous emphysema, ...

hrp0082p3-d3-758 | Diabetes (4) | ESPE2014

Diabetes Insipidus in Pediatric Practice

Sultanova Shakhrizada , Bobohodzhaeva Shakhlo

Background: In pediatric practice, as a rule, differential diagnostics between the three main types of diabetes insipidus DI is to be made: central DI, renal DI and physiological polydipsia of infants – the separation of which is extremely important for the prescription of pathogenetic treatment.Objective: To make a differential diagnostics of various forms of DI.Methods: The study involved 14 patients (ten girls and four boys...

hrp0082p3-d3-759 | Diabetes (4) | ESPE2014

Diabetes Mellitus Type 2 in Pediatrics: an Emerging Reality in Our Country: First Described in Spain

Diez-Lopez Ignacio , Sarasua-Miranda Ainhoa , Lorente-Blazquez Isabel

Background: The diagnosis of increasingly serious in the early years of life obesity has experienced a large epidemiological increased worldwide in recent decades, and especially in our country and in some groups. Many of the metabolic complications (SM) and cardiovascular have their origins in childhood and are closely related to the presence of insulin resistance (IR), which associated complications: hepatic steatosis, endothelial dysfunction, polycystic ovary syndrome (PCOS...