Volume 82 | ESPE2014 | Next issue

ESPE 2014

Dublin, Ireland
18 Sep 2014 - 20 Sep 2014

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Dublin, Ireland; 18-20 September 2014. Further information

hrp0082p3-d1-699 | Diabetes | ESPE2014

Efficacy and Safety of CSII Treatment in Paediatric Age: Long Term Experience of a Tertiary Care Centre in Spain

Roldan Belen , Colino Esmeralda , Martin-Frias Maria , Alvarez Angeles , Yelmo Rosa , Barrio Raquel

Aims: The aims of the study are to evaluate the efficacy and safety of CSII treatment in paediatric patients, to determine if ISPAD criteria for good metabolic control are achieved and to define the general and specific characteristics depending on age and pubertal stage.Methods: Charts of all the patients who started CSII in the last 10 years were reviewed. The cohort consisted of 90 patients (age 10.1±4.4 years, 58% males). Age at start, DM durati...

hrp0082p3-d1-700 | Diabetes | ESPE2014

Diabetic Ketoacidosis in Children with T1DM: an Italian Multicentre Survey

Zucchini Stefano , Bonfanti Riccardo , Buono Pietro , Cardella Francesca , Cauvin Vittoria , Cherubini Valentino , Chiari Giovanni , D'Annunzio Giuseppe , Paola Frongia Anna , Iafusco Dario , Maltoni Giulio , Ippolita Patera Patrizia , Scaramuzza Andrea , Toni Sonia , Tumini Stefano , Rabbone Ivana

Background: Data regarding epidemiology and management of Diabetic Ketoacidosis (DKA) in Italian children with T1D at disease onset are lacking.Method: From 1/1/2012 to 31/12/2013 a survey on DKA was conducted in all paediatric Centres belonging to the Italian Society for Pediatric Diabetology and Endocrinology. DKA was defined according to the ISPAD criteria. The following data were collected: treatment according ISPAD protocol yes or not, type of rehyd...

hrp0082p3-d1-701 | Diabetes | ESPE2014

Changing Presentation of Type 1 Diabetes to a Tertiary Paediatric Centre

Mc Grath Niamh , Mc Glacken-Byrne S M , Hawkes C P , Murphy N P

Background: The prevalence of childhood type 1 diabetes mellitus (T1DM) is increasing and the age at presentation is falling. Late presentation with diabetic ketoacidosis (DKA) is more common in younger children who are at increased risk of cerebral oedema.Objective and hypotheses: To describe the clinical presentation of new onset T1DM to our centre and report time to diagnosis, incidence of DKA, requirement for intensive care and complications.<p c...

hrp0082p3-d1-702 | Diabetes | ESPE2014

Abnormal Blood Glucose as a Prognostic Factor for Adverse Clinical Outcome Among Children with Acute Medical Conditions in Ghana

Ameyaw Emmanuel

Background: Abnormal blood glucose in sick children is known to be common and carries a poor prognosis being associated with increased morbidity and mortality.Aim: To compare the clinical outcome in children admitted to the PEU of KATH with normal and abnormal blood glucose (hypoglycaemia or hyperglycaemia).Method: Prospective cohort study involving 430 children, 215 each with normal and abnormal blood glucose, selected from screen...

hrp0082p3-d1-703 | Diabetes | ESPE2014

Urinary c-Peptid/Creatinine Ratio in Children and Adolescents Diagnosed with Maturity-Onset Diabetes of the Young

Yilmaz Agladioglu Sebahat , Aycan Zehra

Background and hypotheses: Urinary C-peptide creatinine ratio (UCPCR) is a new, non-invasive, economical test recommended in differential diagnoses of maturity-onset diabetes of the young (MODY). There are a few studies on this topic. UCPCR values were determined as >0.2 and >0.7 nmol/mmol with a high specificity and sensitivity in differential diagnosis in the previous two studies, the values were evaluated in only three MODY types (HNF1A/HNF4A/GCK-MODY). We investiga...

hrp0082p3-d1-704 | Diabetes | ESPE2014

A Case with Neonatal Diabetes and Congenital Hypothyroidism due to Glis3 Gene Deletion

Tolga Ozgen Ilker , Kucukkoc Mehmet , Houghton Jayne , Gokce Selim , Cesur Yasar

Background: Neonatal diabetes is a rare disease having usually a genetic origin. Defects in KCNJ11, ABCC8, INS, GCK, and PDX1 genes are more frequent and may lead non-transient, non-syndromic neonatal diabetes, whereas defects in PTF1A, FOXP3, EIF2AK3, GLIS3, RFX6, and NEUROD1 genes are very rare and may lead neonatal diabetes as a part of a syndrome.Objective and hypotheses: We present a patient with GLIS3 ge...

hrp0082p3-d1-705 | Diabetes | ESPE2014

Glycemic Control of Patients with Type 1 Diabetes Using Automated Bolus Calculator Glucometerr

Rojo Jaime Cruz , Lorenzo Lucia Garzon , del Pozo Jaime Sanchez , Gomez Ma Elena Gallego

Background: In the past years, new glucometers with integrated automated bolus calculator, are available in the market for patients whith type 1 diabetes (DM1) in multiple daily injections (MDI) therapy. The limited bibliography about the use of these meters in the pediatric population with DM1, suggests that it may have beneficial effects in terms of glycaemic control and improved quality of life.Objective and hypotheses: The use of a glucometer with an...

hrp0082p3-d1-706 | Diabetes | ESPE2014

Congenital Hyperinsulinism Linked to INS-R Mutation: Case Report

Vitaliti Marcello , Maggio Maria Cristina , Vitaliti Giuliana , Grasso Valeria , Ciofalo Amalia , Rinaudo Grazia , Tranchina Elisa , Costantino Giuseppina , Corsello Giovanni , Barbetti Fabrizio

Background: Leprechaunism, also known as Donohue syndrome, is due to a severe congenital insulin-resistance, with prenatal and neonatal growth retardation, typical dysmorphic features, glycaemic dysregulation with hyperinsulinism and hyperandrogenism.Objective and hypotheses: These patients have a poor prognosis with death in the first year of life.Method: We report the case of a newborn (35.4 weeks) with severe fetal growth restri...

hrp0082p3-d1-707 | Diabetes | ESPE2014

The Lung Endothelin System: a Potent Therapeutic Target with Bosentan for the Amelioration of Lung Alterations in a Rat Model of Diabetes Mellitus

Cayir Atilla , Halici Zekai , Akpinar Erol , Bayraktutan Zafer , Kara Mustafa

Background: Endothelial dysfunction underlies lung and other organ complications developing in associated with diabetes. Endothelial dysfunction leads to an increase in cytokine levels and oxidative stress. Studies have shown that the endothelin plays significant roles in the development of diabetic complications.Objective and hypotheses: The aim of this study is to show the effect of a new mechanism on endothelin receptors in the physiopathology of diab...

hrp0082p3-d1-708 | Diabetes | ESPE2014

Clinical Significance of Typing Fulminant Type 1 Diabetes in Children and Adolescents

Wang Yi , Gong Chunxiu

Background: Fulminant type 1 diabetes (FT1D) is presented as a severe diabetes subtype among adults, however, we have no idea whether it’s worth being taken seriously among children and adolescents.Objective and hypotheses: We aim to clarify the clinical significance of the subtype. It’s supposed that we may needn’t pay special attention to the subtype.Method: Case–control study design. Data from hospitalized al...

hrp0082p3-d1-709 | Diabetes | ESPE2014

Continuous Subcutaneous Insulin Infusion Therapy in Preschool Children with Type 1 Diabetes Mellitus

Moinho Rita , Martins Dora , Almeida Angela , Maia Estefania , Batista Nanci , Aveiro Lina , Capitao Rita , Cardoso Rita , Dinis Isabel , Mirante Alice

Background: A good metabolic control in preschool children with type 1 diabetes (DM1) is particularly challenging, being easier and safer with continuous subcutaneous insulin infusion (CSII) compared with multiple daily injections (MDI).Objective and hypotheses: Evaluate and compare metabolic control of preschool children with DM1, before and 9 months after CSII therapy.Method: Analytical retrospective study of children under the a...

hrp0082p3-d1-710 | Diabetes | ESPE2014

Health-Related Quality of Life Among Turkish Children and Adolescents with Type 1 Diabetes

Aydin Turgay , Kara Cengiz

Background: Health-related quality of life (HRQOL) is defined as a patient’s subjective perception related to the satisfaction with own health. There is no enough data on HRQOL of children and adolescents with type 1 diabetes (T1D) living in Turkey.Objective: To evaluate HRQOL in children and adolescents with T1D compared with healthy controls in Turkey, and to identify HRQOL determinants.Method: A total of 133 children and ad...

hrp0082p3-d1-711 | Diabetes | ESPE2014

Autoimmune Thyroiditis in Georgian Children and Adolescents with Type 1 Diabetes Mellitus

Abdushelishvili Nino , Gordeladze Marine

Background: Over the recent years there have been more and more cases with DM type 1 and thyroid autoimmune diseases.Objective: To study course of autoimmune thyroiditis in children and adolescents with DM type 1.Methods: From 758 children with DM type 1 we identified high risk cohort (thyroid gland palpation and clinical symptoms) and performed thyroid US and TSH, fT4, anti-TPO, anti-TG, and HbA1c testing. Cohort group,...