Volume 82 | ESPE2014 | Next issue

ESPE 2014

Dublin, Ireland
18 Sep 2014 - 20 Sep 2014

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Dublin, Ireland; 18-20 September 2014. Further information

hrp0082p3-d1-974 | Thyroid | ESPE2014

Increasing Incidence of Congenital Hypothyroidism in Neonatal Screening Program in Central Serbia: 30 Years of Experience

Milenkovic Tatjana , Opancina Branka , Mitrovic Katarina , Todorovic Sladjana , Vukovic Rade

Background: Neonatal TSH screening program for congenital hypothyroidism (CH) in Central Serbia was introduced in 1983. Over the past three decades, increasing overall incidence rate of children with both permanent and transient forms of CH has been observed.Objective and hypotheses: The aim of the study was to compare incidence of CH in the first 16 years of screening (period 1) with the last 15 years of screening (period 2). We also investigated the im...

hrp0082p3-d1-975 | Thyroid | ESPE2014

Prevalence of Additional Autoimmune Diseases in Autoimmune’s Thyroiditis Children and Their First- and Second-Degree Relatives: Results from a Large, Single-Center Study

De Martino Lucia , Di Donato Iolanda , Alfano Sara , D'Acunzo Ida , Di Pinto Rosita , Capalbo Donatella , Salerno Mariacarolina

Background: Autoimmune’s thyroiditis (AT) is the most common cause of thyroid diseases in children and adolescents with a peak in early to mid-puberty (prevalence of 0.3–1.2%). Previous studies showed a high rates of familiarity for autoimmune disease (AD) and co-existing autoimmunity in AT subjects.Objective and hypotheses: Aim of our study is to investigate familiarity for AD and co-existing autoimmunity in a large cohort of pediatric AT pati...

hrp0082p3-d1-976 | Thyroid | ESPE2014

Adiposity and Pubertal Status Effects on Thyroid Function in Overweight Children and Adolescents

Giannakopoulos Aristeidis , Pervanidou Panagiota , Lazopoulou Natalia , Chrousos George , Kanaka-Gantenbein Christina

Background: In recent years, studies have consistently demonstrated higher TSH concentrations in overweight/obese children and adults compared with normal weight individuals, whereas the levels of thyroid hormones in peripheral blood remain within normal range. This euthyroid hyperthyrotropinemia on the background of a worldwide increase in childhood obesity raises the question of whether subjects with this elevated TSH should be treated.Objective and hy...

hrp0082p3-d1-977 | Thyroid | ESPE2014

Neonatal Thyrotoxicosis in Maternal Grave’s Disease: a Case Series and Review of the Literature

Johnston Niall , Mavinjurve Meenal , Murphy Nuala , McDonnell Ciara , Moloney Sinead , Cody Declan , Costigan Colm

Background: Neonatal thyrotoxicosis, a rare and life-threatening condition, is caused by transplacental transfer of thyroid stimulating immunoglobulins from mother to infant. While clinical features may include goitre, prominent eyes and poor weight gain, these may be absent in some cases. Early diagnosis and treatment of affected infants is critical.Objective: We report a case series of infants with neonatal thyrotoxicosis from two tertiary paediatric h...

hrp0082p3-d1-978 | Thyroid | ESPE2014

Treatment the Resistance to Thyroid Hormones in Girl

Budzynska Elzbieta , Ben-Skowronek Iwona , Korobowicz Elzbieta , Klatka Maria

Background: The cardinal feature of the resistance to thyroid hormone (RTH) is reduced responsiveness of target tissues to thyroid hormone action caused by thyroid hormone receptor β gene (THRB) mutations impairing hormone binding in the majority (90%) of cases. It results in elevated serum levels of free thyroxine (FT4) and triiodothyronine (FT3) associated with unsuppressed thyroid SH.Objective and hypotheses: The ai...

hrp0082p3-d1-979 | Thyroid | ESPE2014

Free T3/free T4 Ratios in Children with Hypothyroidism Treated with Levothyroxine Monotherapy

Takahashi Tsutomu , Konno Yuki , Takahashi Ikuko

Background: Levothyroxine monotherapy is the treatment of choice for congenital hypothyroidism (CH). Recently, it was reported that levothyroxine monotherapy cannot guarantee euthyroidism in all athyreotic adult patients. A more physiological treatment than levothyroxine monotherapy was suggested to be required in some patients with hypothyroidism.Objective and hypotheses: To elucidate whether levothyroxine monotherapy is appropriate for all children wit...

hrp0082p3-d1-980 | Thyroid | ESPE2014

Diagnostic challenges of thyroid dysfunction in eating disorders

Santhanam Priyha , Denvir Louise , Sachdev Pooja , Randell Tabitha

Background: Anorexia nervosa is usually associated with lower levels of thyroid hormones especially suppressed TSH and T3 with normal T4 levels due to the effects of starvation on metabolism. We present two cases where the underlying eating disorder masked the thyroid dysfunction.Patient 1: 15-year-old girl with anorexia nervosa and BMI of 15.6 was noted to have suppressed TSH<0.1 mU/l, high normal T3–7.0 pmol/l ...

hrp0082p3-d1-981 | Thyroid | ESPE2014

Kocher–Debré–Semelaigne Syndrome with Rhabdomyolysis and Increased Creatinine: a Case Report

Cimbek Emine Ayca , Sen Yasar , Yuca Sevil Ari , Kivanc Demet , Gur Celal , Peru Harun

Background: Hypothyroidism is frequently associated with muscular disorders and sometimes with moderately elevated levels of muscle enzymes. On the other hand, neuromuscular manifestations are rarely the only symptoms/signs present. Kocher–Debré–Semelaigne syndrome is a myopathy of hypothyroidism in childhood characterized by muscular hypertrophy. Rhabdomyolysis due to hypothyroidism is very rare. A very high creatinine kinase level in the range seen with inflam...

hrp0082p3-d1-982 | Thyroid | ESPE2014

Preliminary Result and Normative TSH Values for Healthy Nigerian Newborn Children

Yarhere Iroro , Oduwole Abiola , Suwaid Salma , Yahaya Alkali , Ibekwe Maryanne , Adeniran Kayode , Fetuga Bolanle , Elusiyan Jerome , Idris Hafsat W , Jaja Tamunopriye , Adesiyun Omotayo , Jarrett O O

Background: Congenital hypothyroidism (CH) is the commonest congenital endocrine disorder in the world and also the commonest most preventable cause of mental retardation. Screening is mandatory in developed countries, but none exists in sub-Saharan country. We present a preliminary report of the first Nigerian screening for CH.Objective and hypotheses: To screen normal newborn babies in different regions in Nigeria and to determine the normal range of T...

hrp0082p3-d1-983 | Thyroid | ESPE2014

Resistance to Thyroid Hormone Syndrome from Childhood to Adulthood: Variation in Symptoms and Thyroid Function

Garrahy Aoife , Grace Mariana , Stapleton Mary , Moran Carla , Chatterjee Krishna , Murphy Matthew , O'Connell Susan

Introduction: Resistance to thyroid hormone (RTH) is a rare autosomal dominant condition characterised by tissue-specific insensitivity to thyroid hormone. In 85% of cases the disorder is associated with thyroid hormone receptor β (TRβ) gene mutations.Case report: A 2.6-year-old boy was referred to the Paediatric service with abnormal thyroid function tests (TFTs) (fT4 30.4 pmol/l; RR 12–26, fT3 10.2 pmol/l; RR 3.7&#1...

hrp0082p3-d1-984 | Thyroid | ESPE2014

Thyroid Disorders After Oncologic Treatment in Children

Ben-Skowronek Iwona , Sadurska Elzbieta , Prazmo-Zaucha Agnieszka , Piekarski Robert , Kowalczyk Jerzy

Background: The length of patient survival after cancer treatment is increasing and in some cases does not differ from the average life span in healthy individuals.Objective and hypotheses: The aim of the study is evaluation of thyroid function after oncologic treatment in children.Method: A group of 158 patients aged 16–25 who underwent oncologic treatment in childhood and the control group −66 children and young adults...

hrp0082p3-d1-985 | Thyroid | ESPE2014

Trends in Incidence of Permanent and Transient Congenital Hypothyroidism in Shanghai China

Fan Xin , Gu Xuefan , Luo Jingsi , Qiu Wenjuan , Ye Jun , Chen Shaoke , Xu Jianfeng

Background: Congenital hypothyroidism (CH) is a major target of new born screening. It has two major forms (permanent and transient) that have different prognoses.Objective and hypotheses: The purposes of this study were to assess the trends in incidence of permanent and transient CH in China, and to identify clinical variables that may help to distinguish these two forms of CH.Method: Newborns were screened for CH at Xinhua Hospit...

hrp0082p3-d1-986 | Thyroid | ESPE2014

Klippel-Feil Syndrome and Thyroiditis: a Case Report

Guidoni Elisa , Scarinci Renato , Municchi Giovanna

Background: Klippel–Feil syndrome (KFS) is characterized by congenital fusion of cervical vertebrae and has a prevalence of 1:50 000. The phenotypic expression is variable, sometimes presenting with extraskeletal symptoms.Case report: A girl was referred at the cronological age (CA) of 10.3 years with a suspected diagnosis of Turner syndrome, due to the presence of webbed neck and progressive deceleration of growth velocity. The girl, born in Russia...