Volume 82 | ESPE2014 | Next issue

ESPE 2014

Dublin, Ireland
18 Sep 2014 - 20 Sep 2014

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Dublin, Ireland; 18-20 September 2014. Further information

Poster Presentations

Fat Metabolism & Obesity

hrp0082p1-d1-103 | Fat Metabolism & Obesity | ESPE2014

TNF-Related Apoptosis-Inducing Ligand Induces a Pro-Inflammatory Secretion Profile in Human Adipocytes

Zoller Verena , El Hay Muad Abd , Funcke Jan-Bernd , Debatin Klaus-Michael , Wabitsch Martin , Fischer-Posovszky Pamela

Background: Obesity is tightly associated with adipose tissue inflammation. Tumor necrosis factor-alpha (TNFα) has been identified as a key player in this inflammatory process and has been linked to the development of obesity-associated insulin resistance. Our group studies the involvement of TNF superfamily members in obesity-induced alterations in adipose tissue.Objective and hypotheses: Here, we aimed to identify the effects of the TNF superfamil...

hrp0082p1-d1-104 | Fat Metabolism & Obesity | ESPE2014

Coexistence of Elevated Chitinase 3-Like Protein 1 and von Willebrand Levels in Prepubertal Obese Children

Kyrgios Ioannis , Stylianou Charilaos , Kotanidou Eleni , Galli-Tsinopoulou Assimina

Introduction: Obesity as a chronic inflammatory disease is associated with impaired prothrombotic state leading to atherothrombosis. A variety of prothrombotic factors have been implicated in the pathophysiology of this phenomenon, especially the von Willebrand factor (vWF) produced in endothelium, megakaryocytes and subendothelial connective tissue. The aim of this study was to investigate any possible association between the new inflammatory marker chitinase 3-like protein 1...

hrp0082p1-d1-105 | Fat Metabolism & Obesity | ESPE2014

Being Overweight During the Peripubertal Period Modifies the Leptin Induced Changes in Hypothalamic Neuropeptides Involved in Metabolism but not those Involved in Pubertal Onset

Castro-Gonzalez David , Fuente-Martin Esther , Sanchez-Garrido Miguel A , Argente-Arizon Pilar , Tena-Sempere Manuel , Chowen Julie A , Argente Jesus

Background: Leptin is suggested to be a permissive factor in the onset of puberty by signaling at the level of the hypothalamus to indicate adequate energy stores. Overweight female rats due to increased neonatal nutrition have been shown to develop puberty before normal weight rats.Objective and hypothesis: We hypothesized that this permissive effect may be due not only to increased leptin levels, but also to increased hypothalamic sensitivity to this h...

hrp0082p1-d1-106 | Fat Metabolism & Obesity | ESPE2014

Natural Antibiotics: New Biomarkers of Childhood Obesity

Prats-Puig Anna , Gispert-Sauch Montserrat , Carreras-Badosa Gemma , Diaz-Roldan Ferran , de Zegher Francis , Ibanez Lourdes , Bassols Judit , Lopez-Bermejo Abel

Background: The innate immune system is one of the first lines of host defense against invading pathogens. Pro-inflammatory α-defensins (mainly DEFA1–3) and anti-inflammatory bacterial/permeability-increasing protein (BPI) are antimicrobial peptides predominantly produced by neutrophils which have been recently related to obesity, type 2 diabetes and cardiovascular risk.Objective and hypotheses: The aim of our study was to test whether α-d...

hrp0082p1-d1-107 | Fat Metabolism & Obesity | ESPE2014

Evidence of Early Alterations in Adipose Tissue Biology and Function in Obese Children

Landgraf Katrhin , Rockstroh Denise , Wagner Isabel , Tauscher Roy , Schwartze Julian , Buhligen Ulf , Till Holger , Wojan Magdalena , Kratzsch Jurgen , Kiess Wieland , Bluher Matthias , Korner Antje

Background: Accumulation of fat mass in the development of obesity may result from hypertrophy and/or hyperplasia and is frequently associated with adipose tissue (AT) dysfunction in adults. However, the onset and mechanisms of AT dysfunction are not entirely understood.Objective and hypotheses: We assessed composition, function, lipolysis, and inflammation in 171 AT samples from lean and obese children and adolescents (aged 0 – 18 years) to evaluat...

hrp0082p1-d1-108 | Fat Metabolism & Obesity | ESPE2014

The Impact of Antibiotic Exposure During Infancy on Weight and Height

Saari Antti , Virta Lauri , Sankilampi Ulla , Saxen Harri , Dunkel Leo

Background: Antibiotics have direct effects on human gut, and infant’s intestinal microbiota is particularly vulnerable for perturbation. In mice it was shown that antibiotics increased body fat mass due to changes in composition of the intestinal microbial community. Therefore, antibiotic exposure during infancy could be associated with increase in body mass also in man.Objective and hypotheses: To evaluate impact of antibiotic exposure, and its ti...

hrp0082p1-d1-109 | Fat Metabolism & Obesity | ESPE2014

Identification of Brown Adipocyte Progenitor Marker Genes in Progenitor Cells from Human Deep Neck and Subcutaneous Adipose Tissue by Gene Array Analysis

Tews Daniel , Schwar Verena , Weber Theresia , Scheithauer Marc , Fromme Tobias , Klingenspor Martin , Barth Thomas F , Moller Peter , Fischer-Posovszky Pamela , Wabitsch Martin

Background: Studies in animal models revealed that brown and white adipocytes derive from different progenitor cells. Molecular characteristics of these cells have not been investigated in detail in humans.Objective and hypotheses: To identify novel markers of human brown adipocyte progenitor cells.Method: Progenitor cells from human paired deep neck and subcutaneous adipose tissue samples were obtained from n=12 subjects ...

hrp0082p1-d1-110 | Fat Metabolism & Obesity | ESPE2014

Free Fatty Acids Activate Hypothalamic Astrocytes in a Sexually Dimorphic Manner

Argente-Arizon Pilar , Fuente-Martin Esther , Diaz Francisca , Freire-Regatillo Alejandra , Argente Jesus , Chowen Julie A

Introduction: Obesity is known to associate with chronic systemic inflammation. However, hypothalamic inflammation also occurs in response to high fat diet (HFD)-induced obesity and is proposed to participate in central insulin/leptin resistance and the perpetuation of weight gain and systemic affectation. The weight gain and central responses to HFD differ between males and females. As hypothalamic glial cells are implicated in the central inflammatory response we hypothesize...

hrp0082p1-d1-111 | Fat Metabolism & Obesity | ESPE2014

A Multiplatform Non-targeted Metabolomics Approach to Investigate Insulin Resistance Associated to Obesity in Childhood

Mastrangelo Annalaura , Martos-Moreno Gabriel , Garcia Antonia , Ruperez Francisco , Chowen Julie , Perez-Jurado Luis , Barbas Coral , Argente Jesus

Background: Childhood obesity is often associated with insulin resistance (IR), which is a key risk factor for the development of comorbidities. The etiologic relation between insulin resistance and obesity is still not completely understood.Objective: In this study a multiplatform metabolomics approach was applied for the first time to elucidate the metabolic alterations in obese children with or without IR. Metabolomics is the revolutionary strategy of...

hrp0082p1-d1-112 | Fat Metabolism & Obesity | ESPE2014

Mir-146a and -155 are Involved in FOXO1 Regulation and Non Alcoholic Fatty Liver Disease in Childhood Obesity

Montanini Luisa , Lazzeroni Pietro , Sartori Chiara , Nobili Valerio , Crafa Pellegrino , Bernasconi Sergio , Street Maria E

Background: Non alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in childhood, in obese subjects and associated with insulin resistance.FOXO1 is a key regulator in insulin signalling and in intracellular adipogenesis, and is implicated in liver steatosis. We have previously identified that a group of miRNAs are involved in its epigenetic regulation.Objective and hypotheses: We aimed to assess in liver tissue and in serum whe...