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ESPE 2014

Dublin, Ireland
18 Sep 2014 - 20 Sep 2014

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Dublin, Ireland; 18-20 September 2014. Further information

Poster Presentations

Thyroid (1)

hrp0082p1-d2-244 | Thyroid (1) | ESPE2014

Treatment of Graves’ Disease with Methimazole in Children Alters the Proliferation of Treg Cells and T Lymphocytes

Klatka Maria , Grywalska Ewelina , Wasiak Magdalena , Rolinski Jacek

Background: Graves’ disease (GD) is almost always the cause of hyperthyroidism in children. Studies carried out for recent years confirm an important role of T regulatory cells (Tregs) in the development of autoimmune diseases. However, the interactions between T-cell response and Treg proliferation in GD is still poorly understood.Objective and hypotheses: The aim of this research was the assessment of the in vitro proliferation of Treg ce...

hrp0082p1-d2-245 | Thyroid (1) | ESPE2014

Thyroid Dysfunction in Children After Hematopoietic Stem Cell Transplantation: Short Term Follow-Up for 12 Months

Jeon Yeon Jin , Jung In Ah , Kim Shin Hee , Cho Won-Kyoung , Lee Jae-Wook , Cho Kyoung Soon , Park So Hyun , Chung Nak-Gyun , Jung Min-Ho , Cho Bin , Suh Byung-Kyu

Background: We evaluated 12 months follow-up of thyroid function in patients who underwent hematopoietic stem cell transplantation (HSCT) during childhood and adolescents.Methods: We studied 83 hematologic-malignancy patients (46 boys and 37 girls, acute lymphoblastic leukemia=25, acute myeloid leukemia=51, chronic myelogenous leukemia=7) who underwent HSCT between January 2006 and December 2011.The mean age at HSCT was 9.78±4...

hrp0082p1-d2-246 | Thyroid (1) | ESPE2014

The Effect of L-Thyroxine Treatment on Left Ventricular Functions in Children with Subclinical Hypothyroidism

Catli Gonul , Kir Mustafa , Anik Ahmet , Yilmaz Nuh , Bober Ece , Abaci Ayhan

Background: Subclinical hypothyroidism (SH) is defined as an elevated serum concentration of TSH when serum free thyroxine (fT4) concentration is within its reference range. Impaired myocardial contractility in overt hypothyroidism and left ventricular (LV) diastolic dysfunction in adults with SH as well as beneficial effects of thyroid hormone replacement on systolic and diastolic functions in adults with SH has been documented, however the presence of similar alte...

hrp0082p1-d2-247 | Thyroid (1) | ESPE2014

Urinary Iodine Concentrations in Mothers and their Term Newborns

Krylova Katerina , Bilek Radovan , Bayer Milan , Dejmek Petr , Neumann David

Background: The development of fetal thyroid gland and its function in fetus and newborn are influenced by maternal iodine supplementation and maternal disorders of thyroid gland. Pregnant and lactating women are considered a risk group, although the Czech Republic ranks among countries with sufficient iodine supply. In case of maternal iodine deficiency, fetus is more susceptible to other factors influencing fetal thyroid gland development and function and also its neurologic...

hrp0082p1-d2-248 | Thyroid (1) | ESPE2014

Vitamin D in Adolescents with Hashimoto’s Thyroiditis

Gumeniuk Olga

Background: The results of several studies suggest that vitamin D could possibly decrease the risk of autoimmune diseases.Objective: To evaluate the efficiency of the vitamin D in adolescents with Hashimoto’s thyroiditis (HT).Methods: The study included 32 adolescents (aged 12–17 years, mean age was 14.4±1.3 years) with HT (normal range TSH, fT3, fT4 and elevated antibodies). HT was diagnosed on...

hrp0082p1-d2-249 | Thyroid (1) | ESPE2014

Capillary TSH Cut-off Levels for Congenital Hypothyroidism Screening: Evidence Against Adopting the UK Threshold of 10 mIU/l

Jones Jeremy , Shaikh Guftar , Mason Avril

Background: The recommended capillary TSH cut-off level for neonatal screening for congenital hypothyroidism (CH) in the UK is 10 mIU/l. However several of the regional screening laboratories have adopted lower cut-off limits in order to increase detection sensitivity. There is now pressure to standardise the UK screening programme with universal adoption of the recommended cut-off. Scotland has been using a cut-off of 8 mIU/l since the adoption of AutoDELFIA TSH screening met...

hrp0082p1-d2-250 | Thyroid (1) | ESPE2014

In Patients with Chronic Autoimmune Thyroiditis, Investigation of the Effects of Functions of Regulatory T Cells and Vitamin D

Siklar Zeynep , Karatas Deniz , Dogu Figen , Kocaay Pinar , Hacihamdioglu Bulent , Ikinciogullari Aydan , Berberoglu Merih

Background: Treg cells are characterized by expression of Foxp3 molecule that serve as keys in the maintenance of peripheral tolerance and in controlling the immune response. The exact role of Treg cells in the pathogenesis of CAT has not been recognized yet.Objective and hypotheses: It is suggested that vitamin D is one of the factors that can regulate the function of Treg cells. In this study, the relationship between Treg cells (levels and expression)...

hrp0082p1-d2-251 | Thyroid (1) | ESPE2014

Triiodothyronine-Predominant Graves’ Disease (T3-P-GD): Description and Management in Childhood

Harvengt Julie , Boizeau Priscilla , Zenaty Delphine , Paulsen Anne , Simon Dominique , Crepon Sophie Guilmin , Alberti Corinne , Carel Jean-Claude , Leger Juliane

Background: T3-P-GD, a severe, rare disorder well known in adults, has not previously been described in children. It is characterized by persistently high serum fT3 concentration and normal, or even low, fT4 concentration during drug treatment. This condition is associated with very high titers of TRAb and large goiters, but its pathogenesis remains unclear. The recognition of this form of GD in children is of particular importance, as higher antithyroid ...

hrp0082p1-d2-252 | Thyroid (1) | ESPE2014

Autoimmune Encephalopathy in a Boy with Graves’ Disease

Kucharska Anna , Kadziela Katarzyna , Pyrzak Beata

Background: Autoimmune encephalopathy is usually reported in patient with Hashimoto’s thyroiditis and in Graves’ disease is rather rare, especially in children.Method: We report a boy of 15 years diagnosed with Graves’ disease and treated ineffectively with thyrostatics. After 2 years of the therapy he had recurrence of hyperthyroidism and underwent radical treatment with ablative dose of 131I. After 2 weeks the patient suffered...

hrp0082p1-d2-253 | Thyroid (1) | ESPE2014

Maternal Hypothyroxinemia in Early Pregnancy is Associated with Poorer Arithmetic Performance in a School Test in Offspring at Age 5 Years

Noten Anna , Loomans Eva , Vrijkotte Tanja , van Trotsenburg Paul , van Eijsden Manon , Rotteveel Joost , Finken Martijn

Background: Subtle impairments in the thyroid function of pregnant women are associated with poorer scores on mental developmental scales in their children at age 2–3 years, and with reduced performance in a simple reaction time test at 5–6 years. However, associations with school performance estimates have never been studied.Objective and hypotheses: We aimed to assess the effect of normal variation in the maternal thyroid function during earl...

hrp0082p1-d2-254 | Thyroid (1) | ESPE2014

TSH: Different Normalization Methods, Very Different Normal Upper Limits

Strich David , Karavani Gilad , Gillis David

Background: Distribution of TSH levels is not normal. This is due to physiological changes that cause temporary increases in TSH during physiological events. Several methods are used to normalize the distribution when defining normal limits.Objective and hypotheses: To compare the normal limits defined by three normalization methods vs non-normalized distribution based on a large cohort with no known thyroidal illness.Method: Data ...

hrp0082p1-d2-255 | Thyroid (1) | ESPE2014

Usefulness of Second Screening Strategy for Congenital Hypothyroidism in LBW Neonates

Cavarzere Paolo , Popa Florina Ion , Vincenzi Monica , Camilot Marta , Teofoli Francesca , Morosato Lorella , Maines Evelina , Gaudino Rossella , Lauriola Silvana , Antoniazzi Franco

Background: Thyroid function in preterm infants is often altered for various reasons. LBW or VLBW newborns frequently present a particular form of congenital hypothyroidism (CH) characterized by low FT4 and delayed TSH elevation. The incidence of this disease is 1:250 for VLBW babies and 1:1589 for LBW newborns. In this condition, neonatal screening based solely on TSH can miss the diagnosis, therefore some screening programs have proposed to repeat the screening te...

hrp0082p1-d2-256 | Thyroid (1) | ESPE2014

Screening for Congenital Hypothyroidism in the Russian Federation (1997–2012)

Bezlepkina Olga , Chikulaeva Olga , Chumakova Olga , Karavaeva Lyudmila , Bezlepkin Alexey , Peterkova Valentina

Background: Screening for congenital hypothyroidism (CH) in the Russian Federation started in 1994. A survey was conducted in 1994 on the basis of 32 laboratories, and since 2007 newborn screening is being carried out in 79 laboratories of 83 regions of the Russian Federation.Objective and hypotheses: To study the prevalence of CH in Russia and in different regions of the Russian Federation.Method: Official statistics on CH screeni...