Volume 82 | ESPE2014 | Next issue

ESPE 2014

Dublin, Ireland
18 Sep 2014 - 20 Sep 2014

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Dublin, Ireland; 18-20 September 2014. Further information

Working Groups

Bone & Growth Plate

hrp0082wg1.1 | Bone & Growth Plate | ESPE2014

Unravelling GH Actions on the Growth Plate and its Promotion of Linear Growth

Farquharson Colin

The functional activities of growth plate chondrocytes are tightly controled to regulate the pace of linear growth. Simplistically, growth rate is determined by the number of cells within the proliferative zone which is regulated by their rate of proliferation and also their rate of differentiation into the hypertrophic phenotype. In turn, a strong positive correlation exists between the final hypertrophic cell volume and the rate of growth. Interruption and/or deregulation of...

hrp0082wg1.2 | Bone & Growth Plate | ESPE2014

The Effect of Stimulatory G Proteins on Differentiation within the Growth Plate

Bastepe Murat

Endochondral bone formation regulates bone growth both during embryonic development and after birth. Several different autocrine/paracrine or hormonal mechanisms govern the regulation of endochondral bone formation. Among those is the pathway involving stimulatory G protein, which primarily mediates the actions of parathyroid hormone-related peptide (PTHrP) in the growth plate. PTHrP is synthesized in the perichondrial cells and chondrocytes at the end of bones. In the growing...

hrp0082wg1.3 | Bone & Growth Plate | ESPE2014

New Therapies in Metabolic Bone Disease: Denusomab

Collins M

Osteoclasts are bone-resorbing cells important in normal growth plate development and bone remodeling. The development of osteoclasts is potently driven by mononuclear RANK and osteogenic cell RANKL interaction. Denosumab is a monoclonal antibody drug that targets RANKL and inhibits osteoclastogenesis. It is a potent and effective treatment for pathologic processes that involve bone resorption, such as osteoporosis and bone metastases, conditions for which it is approved. Deno...

hrp0082wg1.4 | Bone & Growth Plate | ESPE2014

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