Objective: To investigate the serum levels of omentin-1 and vaspin in obese children and their correlation with lipid metabolism.
Methods: Fifty-nine children participated in the study, among the 59 subjects, 30 of were obese [(9.43±2.02) years old] and 29 were non-obese controls [(10.3±2.2) years old], there was no statistical difference in age between the two groups. Serum levels of omentin-1 and vaspin were measured by ELISA method.The concentrations of triglyceride (TG), cholesterol (TC), fasting plasma glucose (FPG) and fasting insulin (FINS) were also measured. Body mass index standard deviation score (BMI-SDS) and homeostasis model assessment of insulin resistance (HOMA-IR) were calculated for all participants.
Results: A significant difference of BMI between obese group and control group (24.8±3.4vs16.2±3.2, P=0.000) was observed. Serum levels of TC, LDL-C, FINS, HOMA-IR were significantly higher in obese group than those in control group (all P<0.05). Serum level of omentin-1 was positively correlated with HDL-C (rs=0.405, P=0.026) in obese children. The positive correlations between serum omentin-1 and TC (rs=0.614, P<0.05) in obese girls. There was negative correlation between serum vaspin and TC (rs=−0.621, P=0.031), LDL-C (rs=−0.678, P=0.015) in obese girls.
Conclusion: Serum omentin-1 and vaspin may take part in the lipid metabolism pathogenesis in obese children.
20 - 22 Sep 2014
European Society for Paediatric Endocrinology