ESPE Abstracts (2014) 82 P-D-1-1-234

Association of Toll-Like Receptor-10 Polymorphisms with Autoimmune Thyroid Disease in Korean Children

Won Kyoung Cho, Yeon Jin Jeon, In Ah Jung, Shin Hee Kim, Jung-Pil Jang, Eun-Jeong Choi, Min Ho Jung, Tai-Gyu Kim & Byung-Kyu Suh

College of Medicine, The Catholic University of Korea, SEOUL, Republic of Korea

Background: The Toll-like receptors are germline-encoded receptors that play an essential role in initiating the immune response against pathogens.

Objective and hypotheses: We aimed to assess the association of TLRs polymorphism with autoimmune thyroid disease (AITD) in Korean children.

Method: We define the polymorphism of TLR10, rs4129009, rs11096956, rs10004195 in 85 Korean AITD (GD=50, HD=35; M=16, F=69, mean age=12.9 3.1 years) and 183 controls.

Results: The frequencies of the TLR10 (rs4129009) GG genotype were lower in AITD (OR=0.2, cP=0.01) and non-TAO (OR=0.2, cP=0.03) and A allele was higher in non-TAO (OR=6.4, cP=0.02) than normal group. The frequencies of the TLR10 (rs10004195) AA genotype in AITD (OR=0.4, cP=0.02), GD (OR=0.4 cP=0.02) and non-TAO (OR=0.3, cP=0.02) and A allele in AITD (OR=0.5, cP=0.03) and non-TAO (OR=0.4, cP=0.01) were lower and TT genotype in AITD (OR=2.0, cP=0.05) and non-TAO (OR=2.4, cP=0.02) and T allele in AITD (OR=2.7, cP=0.01) and non-TAO (OR=3.4, cP=0.01) were higher than normal group.

Conclusion: Our results suggest that the polymorphism of TLR 10 might contribute to the pathogenesis of AITD.

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