ESPE Abstracts (2014) 82 P-D-1-3-225

ESPE2014 Poster Presentations Reproduction (2) (10 abstracts)

Treated and Untreated Women with Idiopathic Precocious Puberty: Long-Term General Health Status and Metabolic Outcome Between third and fifth decades

Joseph Meyerovitch a, , Yael Lebenthal a, , Felice Antebi c , Shlomit Shalitin a, , Liat de Vries a, , Moshe Phillip a, & Liora Lazar a,


aThe Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, National Center for Childhood Diabetes, Schneider Children’s Medical Center of Israel, Petah Tikva, Israel; bSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; cResearch and Health Planning Department, Health Planning and Policy Division, Clalit Health Services, Tel Aviv, Israel

Context: Central precocious puberty (CPP), treated or untreated, may have clinical implications in adulthood.

Objective: To assess the general health status and metabolic outcome of former CPP women between the third and fifth decades of life.

Design: Case–control study of an historical cohort using the computerized database of a health management organization.

Participants: Study group – 148 CPP women aged 26–49 years (104 GnRH-analog (GnRHa)-treated; 44 untreated). Control group – 446 women randomly matched for age, year of birth, and community clinic (293 for the GnRHa-treated; 130 for the untreated).

Methods: Extracted from the database were demographic data, medical history and medications dispensed, recorded anthropometric measurements and vital signs and laboratory data.

Outcome Measures: Prevalence of obesity (BMI ≥30), hypertension, hyperlipidemia, diabetes, osteoporosis, and cancer.

Results: The mean current age of the GnRHa-treated and untreated CPP women was 31.5±3.1 and 35.4±4.9 years respectively. The prevalence of obesity, hypertension, hyperlipidemia, and diabetes were similar in the former-CPP women and their controls: GnRHa-treated vs controls (13.9 vs 8.5; 1.9 vs 1; 10.6 vs 10.9; and 1.9 vs 1.7 respectively) and untreated vs controls (19.0 vs 20.0; 2.3 vs 3.1; 18.2 vs 20.8; and 6.8 vs 1.5% respectively), with no significant difference between CPP groups. Osteoporosis was not documented in the former-CPP women. Malignancy rate was low (<5%) and similar in both former-CPP and their controls, with no report of breast cancer among the former-CPP women.

Conclusion: CPP (treated or untreated) is not associated with increased risk of metabolic derangements or malignancy rate in early and mid-adulthood. Health status of former-CPP women is comparable to that of the general population.

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