ESPE Abstracts (2014) 82 P-D-2-1-460

Skeletal Disproportion and Final Adult Height in Childhood-Onset Crohn's Disease

Avril Masona, Jelena Iljuhhinab, Susan Lairdc, David Rossc, Syed Faisal Ahmeda,b, Dan R Gayac & Konstantinos Gerasamidisb


aRHSC, Glasgow, UK; bUniversity of Glasgow, Glasgow, UK; cGlasgow Royal Infirmary, Glasgow, UK


Background: Short stature is a recognized complication of Crohn’s disease (CD) in children. Less is known on the impact of disease on final adult height and body proportions.

Objective and hypotheses: To assess height and body proportions in 48 adults (F: 30; M: 18) with childhood (ACO) or adult (AAO) onset CD and 44 children (C) (F:22; M:22) with CD.

Method: Standing, sitting height (SH) and leg length (SILL) were measured and parental heights were measured (C) or self-reported (A) to calculate mid-parental Ht (MPH).

Results: Although there was no significant difference between the female and male child group of CD, both groups had significantly low SHSDS (Table). In females there was no significant difference in height, SH or SILLSDS between participants with ACO and AAO. However, men with ACO were significantly shorter, below their MPH and had a lower SHSDS than participants with AAO. BMI SDS at recruitment was positively associated with ΔMPHSDS in C group (r, 0.4; P=0.015).

Table 1.
FemaleMaleFemaleMale
CCACOAAOACOAAO
MedRangeMedRangeMedRangeMedRangeMedRangeMed Range
Age (years)13.910:1713.410:17.323.018:3032+22:4020.018:3230+24:39
HtSDS−0.1−2.5:2.0−0.2−2.6:1.5−0.4−1.7:2.1−0.1−1.3:1.8−0.9*#−2.3:00.6+−0.9:1.0
ΔMPHSDS−0.2−2.5:1.3−0.2−2.4:2.40.1−1.5:1−0.2−1.1:1.60.3−0.5:1.5−0.5+−1.5:1.0
SHSDS−0.4*−3.0:1.8−0.5*−2.2:1.0−0.6−2.8:1.8−0.7*−1.6:0.6−1.1*#−2.5:−0.50.2+−0.7:0.8
SILLSDS0.0−2.7:1.6−0.3*−3.0:1.7−0.1−1.5:1.60.3−1.6:1.8−0.3−3.1:1.40.4−0.8:0.9
*P<0.05 compared with UK1990; +P< 0.05 CO vs AO same gender; #P<0.05 between genders of same type of CD; ΔMPH: Target minus actual height SDS.

Conclusion: In children with CD, short stature and skeletal disproportion are present in childhood and persist into adulthood.

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