ESPE Abstracts (2014) 82 P-D-2-2-305

Status of Vitamin D in Pregnancy to Childhood in Northern Spain: Seasonality, Sun Exposure, and Intake

Ana Cristina Rodríguez-Dehlia, Isolina Riaño-Galána, Inés Olaya Velázqueza, Ana Fernández-Somoanob, Ane Miren Castillac, Mercedes Espadac, Eva M Navarrete-Muñozd & Adonina Tardonb

aSan Agustín Hospital, Avilés, Asturias, Spain; bCIBERESP and Oviedo University, Oviedo, Asturias, Spain; cCIBERESP and Public Health Laboratory, Bilbao, País Vasco, Spain; dCIBERESP and Miguel Hernández University, San Juan de Alicante, Comunidad Valenciana, Spain

Background: Vitamin D3 (25OHD) insufficiency is becoming a public health issue. Adequate 25OHD status during pregnancy may influence the health status of the offspring.

Objective and hypotheses: To evaluate the levels of 25OHD during pregnancy (at 12 weeks) and at 4 years old, assessing seasonality, time of sun exposure, and intake.

Method: Data were obtained from 485 pregnant mothers recruited in Asturias between 2004 and 2007 and their children from of the Environment and Childhood (INfancia y Medio Ambiente) (INMA) Project, a population-based birth cohort study.

Results: The mean maternal age was 32 years (range 18–42). 94.1% were term infants and 47.6% female. 25OHD was analyzed in 453 gestations: mean 27.7 ng/ml (range 6.4–69.5). There was no association between 25OHD in pregnancy and birth somatometry. 25OHD was analyzed at 4 years in 260 children: mean 21.36 ng/ml (range 2.8–45) and parathyroid hormone 35.36 pg/ml (15.07–76.40), with normal calcium and phosphorus. Statistically significant relationship was found between 25OHD in pregnancy and at 4 years (Pearson’ r 0.257) and each one with size at 4 years (Pearson’ r 0.167 and 0.190). The 25OHD was lower in winter and spring in gestation and at 4 years. The average pregnant outdoor time was 5 h 35 min (range 0000–1515 h) and at 4 years 0300 (0021–0655 h), without association with 25OHD levels. The median estimated VitD intake was 4.63 g/day (range 0.71–22.52) at pregnancy and 2.74 g/day (range 0.81–12.66) at 4 years.

Conclusion: A high frequency of 25OHD insufficiency/deficiency in pregnancy and at 4 years was found, despite the time of sun exposure as recommended, perhaps due to the latitude of 43°. The estimated intake was lower than recommended in most of the cohort. There is a relationship between levels in pregnancy and at 4 years and both with size at age 4, although not with birth anthropometry.

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